Antifungal Susceptibility Testing, Amphotericin B, Ketoconazole, Voriconazole, and Caspofungin

TEST: 180976
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CPT: 87186
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Synonyms

  • Antifungal Susceptibility Testing
  • Fungal Susceptibility Testing

Expected Turnaround Time

4 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Yeast isolated from a primary clinical specimen on a submitted mycological or bacterial medium

Volume

Pure culture yeast isolate on solid medium

Container

Solid medium, tightly sealed, in etiologic agent packaging

Storage Instructions

Maintain media at room temperature.

Causes for Rejection

Swab received; isolate nonviable; nonyeast isolate (e.g. bacteria or mold); unlabeled specimen or name discrepancy between specimen and request label

Test Details

Use

This test is used to determine the susceptibility of yeast isolates to antifungal agents.

Interpretive criteria are provided for certain organism/drug combinations based on clinical data from infections with Candida spp. Note that the intermediate category provides a buffer zone to limit errors associated with inherent variability in the test method. Strains with intermediate MICs might respond clinically to a higher-than-standard dose of a drug or in situations in which drug penetration is maximized.

Limitations

Susceptibilities cannot be reported if the organism fails to grow in the test medium. Susceptibilities cannot be performed on mixed cultures.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Microbroth dilution (MIC)

References

Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antifungal Susceptibility Testing of Yeasts. 3rd ed. CLSI supplement M27M44S. CLSI; 2022.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
180976 Antifungal Suscep 4 Drugs 29577-4 180969 Yeast ID 42804-5
180976 Antifungal Suscep 4 Drugs 29577-4 998501 Amphotericin B MIC 24-0
180976 Antifungal Suscep 4 Drugs 29577-4 998503 Caspofungin MIC 54176-3
180976 Antifungal Suscep 4 Drugs 29577-4 998507 Ketoconazole MIC 295-6
180976 Antifungal Suscep 4 Drugs 29577-4 998508 Voriconazole MIC 35863-0
Reflex Table for Yeast ID
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 000000 Antimicrobial Susceptibility 000000 Antimicrobial Susceptibility N/A

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