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WC12 2023 -- Cardiovascular disease is the leading cause of death worldwide; however, no regulatory assays are currently available to predict drug/chemical-linked effects on atherosclerosis (an inflammatory process involving a series of progressive cellular events, including monocyte adhesion to the luminal endothelial surface).

Pulmonary fibrosis is a progressive interstitial lung disease characterized by increased deposition of extra cellular matrix and scarring of lung tissue over an extended period of time.

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by increased deposition of extra cellular matrix and scarring of lung tissue over an extended period of time. The deposition of extra cellular matrix and scarring leads to a decline in lung function which is ultimately fatal.

Short term cigarette smoke (CS) exposure in mice has been shown to induce changes exhibiting similarities to cell and cell-mediated inflammation observed in patients with COPD. Evaluate the efficacy of an inhaled PDE4 inhibitor, GSK256066, in a murine 4-day acute cigarette smoke model.

Pulmonary fibrosis is an interstitial lung disease characterised by scarring of the lung tissue leading to a decline in lung function which eventually becomes fatal. There are currently very limited treatment options and even with treatment the life expectancy after diagnosis is only three to five years.

The most objective indicator of asthma severity in the clinic is the measurement of reversible airway obstruction by spirometry. This poster demonstrates that allergen (ovalbumin) challenge results in a reversible decline in measured FEV100, PEF, and FVC in a rat allergic model.