Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by increased deposition of extra cellular matrix and scarring of lung tissue over an extended period. There are currently only two approved treatments for pulmonary fibrosis, both of which slow down the decline in lung function in some patient cohorts.

House dust mite (HDM) allergens are associated with allergic disorders and the use of this clinically relevant antigen is increasing in preclinical animal models. We assessed the chronic inflammatory time course and the anti-inflammatory efficacy of a phosphodiesterase 4 (PDE4) inhibitor and a corticosteroid in a five week HDM model.

Influenza virus infection in humans results in a respiratory disease that ranges in severity from sub-clinical infection to primary viral pneumonia. 40-60% of acute exacerbations in COPD are associated with respiratory virus infection; 85% of asthma attacks in children and 44% in adults are precipitated by upper respiratory tract infection.

ECVP 2023 -- The Extended One-Generation Reproductive Toxicity Study (OECD 2018, Test No. 443) tests for effects of pre- and post-natal chemical exposure. Dosing covers mating, fertility, pregnancy, lactation and development of offspring up to 13 weeks of age.

Scientists at Labcorp have run close to 3,500 preclinical immuno-oncology studies over the past ?ve years. While new models continue to be developed, our scientists have found the following to be their commonly used "workhorse" models, time-tested and optimized for evaluating a wide range of therapeutic approaches.

When it comes to access to oncology drugs, cancer patients can't wait. That's why making quick decisions about early candidates is vital to providing life-changing drugs faster.

Access a comprehensive suite of discovery vaccine testing services, enabling the development of human and veterinary vaccines against viral and bacterial pathogens.

NSH 2023 -- Decalcification is routinely used technique in most histopathological laboratories for the microscopic examination and the bone decalcification has been used in histology processing for many years. The purpose of decalcification is to remove calcium salts from mineralized tissue, resulting in preservation of organic components.

ISSX NA 2023 -- Oligonucleotides have emerged as a promising therapeutic area, particularly for diseases where conventional drugs have not found success. Oligonucleotides are usually modified to improve delivery, stability and pharmacokinetic profiles.

ISSX NA 2023 -- In vitro models play key roles in drug discovery, allowing for the prediction of in vivo metabolism and pharmacokinetics (DMPK) parameters while minimizing cost and maximizing throughput. Primary human hepatocytes (PHH) are often used as a liver model to predict metabolic stability and intrinsic clearance (CLint) of new drug compounds.