The number of deaths caused by lung cancer peaked in 2005 at 159,292 and has been gradually declining ever since.^[1] However, the five-year lung cancer survival rate is only around 20% and is considerably lower than other cancers.

To produce Kymriah? or Yescarta?, a patient?s T cells are engineered to express Chimeric Antigen Receptors (CARs) specific for the CD19 B lymphocyte molecule (1).

Treatment options for CRC are highly dependent on the stage of disease, but many patients receive cocktails of chemotherapies and in some cases radiation treatment along with chemotherapy. A number of preclinical xenograft models exist that allow pharmaceutical and biotech companies to investigate new treatment approaches for CRC.

Ovarian cancer is an unmet medical need and particularly lethal because it is often detected only when disease is quite advanced. In 2017, approximately 22,440 women will be diagnosed with ovarian cancer in the United States, and approximately 14,080 deaths will occur.

Preclinically there are few options to test effects of clinically relevant radiation therapy approaches. Labcorp has a Small Animal Radiation Research Platform (SARRP; Xstrahl) in house and can provide a solution to this currently unmet preclinical need.

In the Western population, hepatitis C, alcoholic cirrhosis, and non-alcoholic steatohepatitis (NASH) are the main underlying causes.

Unfortunately, these tumors can often be radioresistant and surgical removal of the entire tumor may not be possible. Glioblastoma (GBM) is a highly complex disease with little effective treatment options. New Immunotherapy drugs provide an alternate approach to treatment, aiming to bolster the immune system to eradicate disease.

Immunotherapy drugs provide an alternate approach to treatment, aiming to bolster the immune system to eradicate disease. In the past, use of antibody therapies has been limited in GBM due to the obstruction caused by the blood brain barrier to therapy delivery.

One of the most commonly utilized syngeneic mouse models of mammary cancer is 4T1. We have characterized our 4T1-luc2 model to support studies with novel immuno-oncology agents.

Adoptive cell therapy (ACT) with T-cells reprogrammed to express chimeric antigen receptors (CAR T-cells) bind specific antigens on the surface of cancer cells and trigger a cytotoxic response.