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Human Immunodeficiency Virus 1 (HIV-1) GenoSure Archive® Plus Trofile® DNA

Test Number 552020
Test number copied
CPT Call 800-222-7566, ext 6-8400, for coding.
Synonyms
  • Cell-associated Viral DNA
  • HIV-1 Genotype
  • Resistance Analysis

Test Details

Methodology

GenoSure Archive®: Polymerase chain reaction (PCR) amplification and next generation DNA sequencing

Trofile® DNA: Polymerase chain reaction (PCR) amplification and viral culture.

Result Turnaround Time

16 - 22 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

For more information, please view the literature below.

Coreceptor Tropism Assays

GenoSure Archive®: Cell-associated Viral DNA Assay for HIV-1 Protease, Reverse Transcriptase, and Integrase Inhibitors

GenoSure Archive®: HIV-1 Next Generation DNA Sequencing Assay for Suppression Management

HIV Specimen Collection Guide

HIV-1 Lifecycle, Drugs, and Susceptibility Assays

Use

Detect resistance of HIV-1 to protease, reverse transcriptase, and integrase inhibitors (GenoSure Archive®) and detect HIV-1 coreceptor tropism (Trofile® DNA) in cell-associated viral DNA; determine eligibility for CCR5 antagonist therapy, such as maraviroc (Selzentry®).

Limitations

This procedure should be used for patients with documented HIV-1 infection and undetectable viral load or low level viremia.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

References

Günthard HF, Aberg JA, Eron JJ, et al. Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA. 2014 Jul 23-30; 312(4):410-425. 25038359
Hurt C. Transmitted resistance to HIV integrase strand-transfer inhibitors: Right on schedule. Antivir Ther. 2011; 16(2):137-140. 21447861
Panel on Antiretroviral Guidelines for Adults and Adolescents—A Working Group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Washington, DC: Department of Health and Human Services; May 1, 2014.
Whitcomb JM, Huang W, Fransen S, et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob Agents Chemother. 2007 Feb; 51(2):566-575. 17116663

Specimen Requirements

Specimen

Whole blood, frozen

Volume

8 mL

Container

Lavender-top (EDTA) tube

Collection Instructions

Collect specimen in two lavender-top (EDTA) tubes. Do not centrifuge. Ship frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze.

Causes for Rejection

Quantity not sufficient for analysis; heparinized plasma; nonfrozen specimen

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
552020 GS Archive(R)+Trofile(R) DNA 551791 PDF 80695-0
552020 GS Archive(R)+Trofile(R) DNA 551792 HIV GenoSure Archive N/A
552020 GS Archive(R)+Trofile(R) DNA 551793 HIV GenoSure Archive 80693-5
552020 GS Archive(R)+Trofile(R) DNA 551794 HIV GenoSure Archive Interp 80694-3
552020 GS Archive(R)+Trofile(R) DNA 550341 Trofile(R) DNA PDF 51969-4
552020 GS Archive(R)+Trofile(R) DNA 550347 Tropotype: 80690-1
552020 GS Archive(R)+Trofile(R) DNA 829671 Trofile(R) DNA 50790-5
552020 GS Archive(R)+Trofile(R) DNA 829672 Trofile(R) DNA Interpretation 62364-5
Order Code552020
Order Code NameGS Archive(R)+Trofile(R) DNA
Order Loinc
Result Code551791
Result Code NamePDF
UofM
Result LOINC80695-0
Order Code552020
Order Code NameGS Archive(R)+Trofile(R) DNA
Order Loinc
Result Code551792
Result Code NameHIV GenoSure Archive
UofM
Result LOINCN/A
Order Code552020
Order Code NameGS Archive(R)+Trofile(R) DNA
Order Loinc
Result Code551793
Result Code NameHIV GenoSure Archive
UofM
Result LOINC80693-5
Order Code552020
Order Code NameGS Archive(R)+Trofile(R) DNA
Order Loinc
Result Code551794
Result Code NameHIV GenoSure Archive Interp
UofM
Result LOINC80694-3
Order Code552020
Order Code NameGS Archive(R)+Trofile(R) DNA
Order Loinc
Result Code550341
Result Code NameTrofile(R) DNA PDF
UofM
Result LOINC51969-4
Order Code552020
Order Code NameGS Archive(R)+Trofile(R) DNA
Order Loinc
Result Code550347
Result Code NameTropotype:
UofM
Result LOINC80690-1
Order Code552020
Order Code NameGS Archive(R)+Trofile(R) DNA
Order Loinc
Result Code829671
Result Code NameTrofile(R) DNA
UofM
Result LOINC50790-5
Order Code552020
Order Code NameGS Archive(R)+Trofile(R) DNA
Order Loinc
Result Code829672
Result Code NameTrofile(R) DNA Interpretation
UofM
Result LOINC62364-5
Reflex Table for HIV GenoSure Archive
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551781 HIV GSArchive 551781 HIV GSArchive N/A
Reflex 1
Order Code551781
Order NameHIV GSArchive
Result Code551781
Result NameHIV GSArchive
UofM
Result LOINCN/A
Reflex Table for HIV GenoSure Archive
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551782 HIV GSArchive Interp 551782 HIV GSArchive Interp N/A
Reflex 1
Order Code551782
Order NameHIV GSArchive Interp
Result Code551782
Result NameHIV GSArchive Interp
UofM
Result LOINCN/A