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Human Immunodeficiency Virus 1 (HIV-1) DNA Sequencing Integrase

Test Number 551965
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Synonyms
  • Cell-associated Viral DNA
  • HIV-1 Genotype
  • Resistance Analysis

Test Details

Methodology

Polymerase chain reaction (PCR) amplification and next generation DNA sequencing

Result Turnaround Time

10 - 14 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Coreceptor Tropism Assays

GenoSure Archive℠: Cell-associated Viral DNA Assay for HIV-1 Protease, Reverse Transcriptase, and Integrase Inhibitors

GenoSure Archive℠: HIV-1 Next Generation DNA Sequencing Assay for Suppression Management

HIV Specimen Collection Guide

HIV-1 Lifecycle, Drugs, and Susceptibility Assays

Use

Detect resistance of HIV-1 to integrase inhibitors in cell-associated viral DNA.

Limitations

This procedure should be used for patients with documented HIV-1 infection and undetectable viral load or low level viremia.

Specimen Requirements

Specimen

Whole blood, frozen

Volume

4 mL

Collection Instructions

Collect specimen in lavender-top (EDTA) tube. Do not centrifuge. Ship frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze.

Causes for Rejection

Quantity not sufficient for analysis; heparinized plasma; nonfrozen specimen

References

Günthard HF, Aberg JA, Eron JJ, et al. Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA. 2014 Jul 23-30; 312(4):410-425. 25038359
Hurt C. Transmitted resistance to HIV integrase strand-transfer inhibitors: Right on schedule. Antivir Ther. 2011; 16(2):137-140. 21447861
Panel on Antiretroviral Guidelines for Adults and Adolescents—A Working Group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Washington, DC: Department of Health and Human Services; May 1, 2014.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
551965 DNA Sequencing Integrase 551968 PDF 80695-0
551965 DNA Sequencing Integrase 551966 HIV DNA Sequencing IN N/A
551965 DNA Sequencing Integrase 551967 HIV DNA Sequencing IN 80691-9
551965 DNA Sequencing Integrase 551963 HIV DNA Sequencing IN Interp 80694-3
Order Code551965
Order Code NameDNA Sequencing Integrase
Order Loinc
Result Code551968
Result Code NamePDF
UofM
Result LOINC80695-0
Order Code551965
Order Code NameDNA Sequencing Integrase
Order Loinc
Result Code551966
Result Code NameHIV DNA Sequencing IN
UofM
Result LOINCN/A
Order Code551965
Order Code NameDNA Sequencing Integrase
Order Loinc
Result Code551967
Result Code NameHIV DNA Sequencing IN
UofM
Result LOINC80691-9
Order Code551965
Order Code NameDNA Sequencing Integrase
Order Loinc
Result Code551963
Result Code NameHIV DNA Sequencing IN Interp
UofM
Result LOINC80694-3
Reflex Table for HIV DNA Sequencing IN
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551964 HIVDNASeq IN 551964 HIVDNASeq IN N/A
Reflex 1
Order Code551964
Order NameHIVDNASeq IN
Result Code551964
Result NameHIVDNASeq IN
UofM
Result LOINCN/A
Reflex Table for HIV DNA Sequencing IN
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551969 HIVDNASeq IN Interp 551969 HIVDNASeq IN Interp N/A
Reflex 1
Order Code551969
Order NameHIVDNASeq IN Interp
Result Code551969
Result NameHIVDNASeq IN Interp
UofM
Result LOINCN/A