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Human Immunodeficiency Virus 1 (HIV-1) GenoSure® MG Genotyping

Test Number 551697
Test number copied
CPT Call 800-222-7566, ext 6-8400, for coding.
Synonyms
  • HIV-1 Genotype
  • Resistance Analysis
  • Retroviral Genotype

Test Details

Methodology

Polymerase chain reaction (PCR) amplification and DNA sequencing

Result Turnaround Time

12 - 15 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Assays to Support HIV Treatment Decisions

HIV Specimen Collection Guide

HIV-1 Lifecycle, Drugs, and Susceptibility Assays

Human Immunodeficiency Virus 1/O/2 Cascade: Fourth-generation Antigen/Antibody Detection

Use

Detect resistance in HIV-1 to antiretroviral drugs targeted at the reverse transcriptase (nucleoside and nonnucleoside inhibitors) and protease.

Special Instructions

A separate frozen specimen is required for each frozen test ordered.

Limitations

This procedure may not be successful when the HIV viral load is <500 copies/mL plasma. If there is insufficient virus to produce results, HIV-1 RNA quantitation will be performed to confirm viral load, and the procedure will be billed at the account's prevailing fee.

References

Hirsch MS, Brun-Vézinet F, D'Aquila RT, et al. Antiretroviral drug resistance testing in adult HIV-1 infection. Recommendations of an International AIDS Society-USA panel. JAMA. 2000; 283(18):2417-2426. 10815085

Specimen Requirements

Specimen

Plasma, frozen

Volume

5 mL

Container

Lavender-top (EDTA) or plasma preparation tube (PPT™)

Collection Instructions

Collect specimen in three lavender-top (EDTA) tubes or three PPT™ tubes. Do not use green-top (heparin) tubes. Centrifuge specimen within six hours of collection. Transfer plasma to one or more screw-cap polypropylene transport tube(s). Snap-cap or pop-top tubes should be avoided and may result in specimen rejection. Immediately freeze specimen at -20°C. Do not place samples on dry ice until completely frozen. Specimens collected in PPT™ need to be centrifuged within six hours and frozen. Ship specimens frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze.

Causes for Rejection

PPT™ not centrifuged; insufficient volume; heparinized plasma; nonfrozen specimens; specimens exposed to repeated freeze/thaw cycles

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
551697 GenoSure(R) MG 53798-5 551693 PDF 49573-9
551697 GenoSure(R) MG 53798-5 551656 HIV GenoSure(R) 93047-9
551697 GenoSure(R) MG 53798-5 551657 HIV GenoSure(R) 53798-5
Order Code551697
Order Code NameGenoSure(R) MG
Order Loinc53798-5
Result Code551693
Result Code NamePDF
UofM
Result LOINC49573-9
Order Code551697
Order Code NameGenoSure(R) MG
Order Loinc53798-5
Result Code551656
Result Code NameHIV GenoSure(R)
UofM
Result LOINC93047-9
Order Code551697
Order Code NameGenoSure(R) MG
Order Loinc53798-5
Result Code551657
Result Code NameHIV GenoSure(R)
UofM
Result LOINC53798-5
Reflex Table for HIV GenoSure(R)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551318 Quant, RNA PCR 551311 HIV-1 RNA by PCR copies/mL 20447-9
Reflex 1
Order Code551318
Order NameQuant, RNA PCR
Result Code551311
Result NameHIV-1 RNA by PCR
UofMcopies/mL
Result LOINC20447-9
Reflex Table for HIV GenoSure(R)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551318 Quant, RNA PCR 551312 log10 HIV-1 RNA log10copy/mL 29541-0
Reflex 1
Order Code551318
Order NameQuant, RNA PCR
Result Code551312
Result Namelog10 HIV-1 RNA
UofMlog10copy/mL
Result LOINC29541-0
Reflex Table for HIV GenoSure(R)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551624 HIV GenoSure(R) MG 551624 HIV GenoSure(R) MG 49573-9
Reflex 1
Order Code551624
Order NameHIV GenoSure(R) MG
Result Code551624
Result NameHIV GenoSure(R) MG
UofM
Result LOINC49573-9
Reflex Table for HIV GenoSure(R)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 551619 HIV GenoSure(R) MG Interp 551619 HIV GenoSure(R) MG Interp 49573-9
Reflex 1
Order Code551619
Order NameHIV GenoSure(R) MG Interp
Result Code551619
Result NameHIV GenoSure(R) MG Interp
UofM
Result LOINC49573-9