Autoimmune Epilepsy Evaluation Profile, Spinal Fluid

Test Number 505595

Test number copied

CPT 86255(x21); 86341

Synonyms

Autoimmune Paraneoplastic Panel Spinal Fluid
Paraneoplastic

Test Details

Methodology

Immunofluorescence, Immunoblot

Result Turnaround Time

4 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Autoimmune Neurology/Comprehensive Paraneoplastic Profile

Use

This test is used for the detection of antineuronal autoantibodies that help in the diagnosis of paraneoplastic syndromes and autoimmune encephalopathies and related conditions.

Special Instructions

If reflex test is performed, additional charges/CPT code(s) may apply.

Limitations

This test was developed and its performance characteristics determined by Labcorp in accordance with CLIA requirements. This test has not been cleared or approved by the Food and Drug Administration.

Custom Additional Information

This test should be considered for the differential evaluation of encephalopathy of unknown origin with subacute onset of seizures, confusion, memory loss and/or behavioral change. For adults and patients with suspicion of cancer, additional evaluation of paraneoplastic autoantibodies is recommended (see Test No. 505500).

Specimen Requirements

Specimen

Cerebrospinal fluid (CSF)

Volume

2 mL

Minimum Volume

1 mL

Container

Sterile plastic tube

Stability Requirements

Temperature	Period
Room temperature	14 days
Refrigerated	14 days
Frozen	14 days
Freeze/thaw cycles	Stable x3

Storage Instructions

Room temperature

Causes for Rejection

Gross hemolysis; grossly lipemic; gross icterus

LOINC® Map

Order Code	Order Code Name	Order Loinc	Result Code	Result Code Name	Result LOINC
505595	Autoimmune Epilepsy CSF	94818-2	505562	Interpretation	56850-1
505595	Autoimmune Epilepsy CSF	94818-2	505611	Anti-Hu Ab	44768-0
505595	Autoimmune Epilepsy CSF	94818-2	505612	Anti-Ri Ab	56959-0
505595	Autoimmune Epilepsy CSF	94818-2	505613	Antineuronal nuclear Ab Type 3	90836-8
505595	Autoimmune Epilepsy CSF	94818-2	505616	PCA Type-1 (Anti-Yo) Ab	14247-1
505595	Autoimmune Epilepsy CSF	94818-2	505617	Purkinje Cell Cyto Ab Type 2	90843-4
505595	Autoimmune Epilepsy CSF	94818-2	505618	Purkinje Cell Cyto Ab Type Tr	90845-9
505595	Autoimmune Epilepsy CSF	94818-2	505619	Amphiphysin Antibody	90815-2
505595	Autoimmune Epilepsy CSF	94818-2	505621	CRMP-5 IgG	63216-6
505595	Autoimmune Epilepsy CSF	94818-2	505623	AGNA-1	90827-7
505595	Autoimmune Epilepsy CSF	94818-2	505624	DPPX Antibody	82989-5
505595	Autoimmune Epilepsy CSF	94818-2	505626	mGluR1 Antibody	93500-7
505595	Autoimmune Epilepsy CSF	94818-2	505697	IgLON5 Antibody	96481-7
505595	Autoimmune Epilepsy CSF	94818-2	505698	Ma2/Ta Antibody	90832-7
505595	Autoimmune Epilepsy CSF	94818-2	505699	Zic4 Antibody	101229-3
505595	Autoimmune Epilepsy CSF	94818-2	505702	DNER Antibody	90844-2
505595	Autoimmune Epilepsy CSF	94818-2	505589	AMPA-R-1 Cell-based IFA	90811-1
505595	Autoimmune Epilepsy CSF	94818-2	505593	AMPA-R-2 Cell-based IFA	93491-9
505595	Autoimmune Epilepsy CSF	94818-2	505597	GABA-B Receptor Cell-based IFA	93426-5
505595	Autoimmune Epilepsy CSF	94818-2	505599	NMDAR Antibody, Cell-based IFA	82988-7
505595	Autoimmune Epilepsy CSF	94818-2	505704	GAD65 Antibody, Cell-based IFA	94711-9
505595	Autoimmune Epilepsy CSF	94818-2	505636	CASPR2 Antibody,Cell-based IFA	90820-2
505595	Autoimmune Epilepsy CSF	94818-2	505637	LGI1 Antibody, Cell-based IFA	90830-1
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505562
Result Code Name	Interpretation
UofM
Result LOINC	56850-1
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505611
Result Code Name	Anti-Hu Ab
UofM
Result LOINC	44768-0
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505612
Result Code Name	Anti-Ri Ab
UofM
Result LOINC	56959-0
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505613
Result Code Name	Antineuronal nuclear Ab Type 3
UofM
Result LOINC	90836-8
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505616
Result Code Name	PCA Type-1 (Anti-Yo) Ab
UofM
Result LOINC	14247-1
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505617
Result Code Name	Purkinje Cell Cyto Ab Type 2
UofM
Result LOINC	90843-4
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505618
Result Code Name	Purkinje Cell Cyto Ab Type Tr
UofM
Result LOINC	90845-9
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505619
Result Code Name	Amphiphysin Antibody
UofM
Result LOINC	90815-2
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505621
Result Code Name	CRMP-5 IgG
UofM
Result LOINC	63216-6
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505623
Result Code Name	AGNA-1
UofM
Result LOINC	90827-7
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505624
Result Code Name	DPPX Antibody
UofM
Result LOINC	82989-5
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505626
Result Code Name	mGluR1 Antibody
UofM
Result LOINC	93500-7
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505697
Result Code Name	IgLON5 Antibody
UofM
Result LOINC	96481-7
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505698
Result Code Name	Ma2/Ta Antibody
UofM
Result LOINC	90832-7
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505699
Result Code Name	Zic4 Antibody
UofM
Result LOINC	101229-3
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505702
Result Code Name	DNER Antibody
UofM
Result LOINC	90844-2
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505589
Result Code Name	AMPA-R-1 Cell-based IFA
UofM
Result LOINC	90811-1
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505593
Result Code Name	AMPA-R-2 Cell-based IFA
UofM
Result LOINC	93491-9
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505597
Result Code Name	GABA-B Receptor Cell-based IFA
UofM
Result LOINC	93426-5
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505599
Result Code Name	NMDAR Antibody, Cell-based IFA
UofM
Result LOINC	82988-7
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505704
Result Code Name	GAD65 Antibody, Cell-based IFA
UofM
Result LOINC	94711-9
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505636
Result Code Name	CASPR2 Antibody,Cell-based IFA
UofM
Result LOINC	90820-2
Order Code	505595
Order Code Name	Autoimmune Epilepsy CSF
Order Loinc	94818-2
Result Code	505637
Result Code Name	LGI1 Antibody, Cell-based IFA
UofM
Result LOINC	90830-1

Reflex Table for Anti-Hu Ab
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505563	Anti-Hu Ab Line Blot	505563	Anti-Hu Ab Line Blot	Pending
Reflex 1
Order Code	505563
Order Name	Anti-Hu Ab Line Blot
Result Code	505563
Result Name	Anti-Hu Ab Line Blot
UofM
Result LOINC	Pending

Reflex Table for Anti-Ri Ab
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505564	Anti-Ri Ab Line Blot	505564	Anti-Ri Ab Line Blot	Pending
Reflex 1
Order Code	505564
Order Name	Anti-Ri Ab Line Blot
Result Code	505564
Result Name	Anti-Ri Ab Line Blot
UofM
Result LOINC	Pending

Reflex Table for PCA Type-1 (Anti-Yo) Ab
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505566	Anti-Yo Ab Line Blot	505566	Anti-Yo Ab Line Blot	94272-2
Reflex 1
Order Code	505566
Order Name	Anti-Yo Ab Line Blot
Result Code	505566
Result Name	Anti-Yo Ab Line Blot
UofM
Result LOINC	94272-2

Reflex Table for Purkinje Cell Cyto Ab Type Tr
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505567	PCA-Tr Line Blot	505567	PCA-Tr Line Blot	95596-3
Reflex 1
Order Code	505567
Order Name	PCA-Tr Line Blot
Result Code	505567
Result Name	PCA-Tr Line Blot
UofM
Result LOINC	95596-3

Reflex Table for Amphiphysin Antibody
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505568	Amphiphysin Line Blot	505568	Amphiphysin Line Blot	57750-2
Reflex 1
Order Code	505568
Order Name	Amphiphysin Line Blot
Result Code	505568
Result Name	Amphiphysin Line Blot
UofM
Result LOINC	57750-2

Reflex Table for CRMP-5 IgG
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505622	CRMP-5 IgG Line Blot	505622	CRMP-5 IgG Line Blot	53707-6
Reflex 1
Order Code	505622
Order Name	CRMP-5 IgG Line Blot
Result Code	505622
Result Name	CRMP-5 IgG Line Blot
UofM
Result LOINC	53707-6

Reflex Table for AGNA-1
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505569	AGNA-1 Line Blot	505569	AGNA-1 Line Blot	94383-7
Reflex 1
Order Code	505569
Order Name	AGNA-1 Line Blot
Result Code	505569
Result Name	AGNA-1 Line Blot
UofM
Result LOINC	94383-7

Reflex Table for DPPX Antibody
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505571	DPPX Cell-based IFA	505571	DPPX Cell-based IFA	101242-6
Reflex 1
Order Code	505571
Order Name	DPPX Cell-based IFA
Result Code	505571
Result Name	DPPX Cell-based IFA
UofM
Result LOINC	101242-6

Reflex Table for mGluR1 Antibody
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505574	mGluR1 Cell-based IFA	505574	mGluR1 Cell-based IFA	93498-4
Reflex 1
Order Code	505574
Order Name	mGluR1 Cell-based IFA
Result Code	505574
Result Name	mGluR1 Cell-based IFA
UofM
Result LOINC	93498-4

Reflex Table for IgLON5 Antibody
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505694	IgLON5 Cell-based IFA	505694	IgLON5 Cell-based IFA	96481-7
Reflex 1
Order Code	505694
Order Name	IgLON5 Cell-based IFA
Result Code	505694
Result Name	IgLON5 Cell-based IFA
UofM
Result LOINC	96481-7

Reflex Table for Ma2/Ta Antibody
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505692	Ma2/Ta Line Blot	505692	Ma2/Ta Line Blot	90833-5
Reflex 1
Order Code	505692
Order Name	Ma2/Ta Line Blot
Result Code	505692
Result Name	Ma2/Ta Line Blot
UofM
Result LOINC	90833-5

Reflex Table for Zic4 Antibody
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505696	Zic4 Line Blot	505696	Zic4 Line Blot	88743-0
Reflex 1
Order Code	505696
Order Name	Zic4 Line Blot
Result Code	505696
Result Name	Zic4 Line Blot
UofM
Result LOINC	88743-0

Reflex Table for DNER Antibody
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505643	DNER Line Blot	505643	DNER Line Blot	Pending
Reflex 1
Order Code	505643
Order Name	DNER Line Blot
Result Code	505643
Result Name	DNER Line Blot
UofM
Result LOINC	Pending

Reflex Table for AMPA-R-1 Cell-based IFA
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505591	AMPA-R-1 IF Titer	505591	AMPA-R-1 IF Titer	95604-5
Reflex 1
Order Code	505591
Order Name	AMPA-R-1 IF Titer
Result Code	505591
Result Name	AMPA-R-1 IF Titer
UofM
Result LOINC	95604-5

Reflex Table for AMPA-R-2 Cell-based IFA
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505596	AMPA-R-2 IF Titer	505596	AMPA-R-2 IF Titer	Pending
Reflex 1
Order Code	505596
Order Name	AMPA-R-2 IF Titer
Result Code	505596
Result Name	AMPA-R-2 IF Titer
UofM
Result LOINC	Pending

Reflex Table for GABA-B Receptor Cell-based IFA
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505598	GABA-B Receptor Antibody Titer	505598	GABA-B Receptor Antibody Titer	Pending
Reflex 1
Order Code	505598
Order Name	GABA-B Receptor Antibody Titer
Result Code	505598
Result Name	GABA-B Receptor Antibody Titer
UofM
Result LOINC	Pending

Reflex Table for NMDAR Antibody, Cell-based IFA
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505606	Anti-NMDAR Antibody Titer	505606	Anti-NMDAR Antibody Titer	90840-0
Reflex 1
Order Code	505606
Order Name	Anti-NMDAR Antibody Titer
Result Code	505606
Result Name	Anti-NMDAR Antibody Titer
UofM
Result LOINC	90840-0

Reflex Table for GAD65 Antibody, Cell-based IFA
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505691	Anti-GAD65 Antibody Titer	505691	Anti-GAD65 Antibody Titer	Pending
Reflex 1
Order Code	505691
Order Name	Anti-GAD65 Antibody Titer
Result Code	505691
Result Name	Anti-GAD65 Antibody Titer
UofM
Result LOINC	Pending

Reflex Table for CASPR2 Antibody,Cell-based IFA
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505608	Anti-CASPR2 Antibody Titer	505608	Anti-CASPR2 Antibody Titer	90820-2
Reflex 1
Order Code	505608
Order Name	Anti-CASPR2 Antibody Titer
Result Code	505608
Result Name	Anti-CASPR2 Antibody Titer
UofM
Result LOINC	90820-2

Reflex Table for LGI1 Antibody, Cell-based IFA
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	505609	Anti-LGI1 Antibody Titer	505609	Anti-LGI1 Antibody Titer	90831-9
Reflex 1
Order Code	505609
Order Name	Anti-LGI1 Antibody Titer
Result Code	505609
Result Name	Anti-LGI1 Antibody Titer
UofM
Result LOINC	90831-9

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