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Autoimmune Neurology/Comprehensive Paraneoplastic Profile

Test Number 505500
Test number copied
CPT 86051; 86255(x22); 86341; 86596
Synonyms
  • Antineuronal Autoantibodies Test
  • Autoimmune Paraneoplastic Panel
  • Paraneoplastic
  • Paraneoplastic Syndrome Test

Test Details

Methodology

Immunofluorescence, EIA, Radioimmunoassay, Immunoblot

Result Turnaround Time

5 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Use

For the detection of antineuronal autoantibodies that help in the diagnosis of paraneoplastic syndromes and autoimmune encephalopathies and related conditions

Limitations

A negative autoimmune neurology/paraneoplastic profile result does not rule out all clinically relevant antibodies. If indicated, a phenotype-specific profile (for example, encephalopathy, dementia, myelopathy, or axonal neuropathy) should be considered.

This test was developed and its performance characteristics determined by Labcorp in accordance with CLIA requirements. This test has not been cleared or approved by the Food and Drug Administration.

Custom Additional Information

Autoimmune Neurology/Paraneoplastic Profile is a broad autoantibody panel that is more likely to capture causative autoantibodies and should be considered, especially when the clinical presentation is unclear, is shared by multiple antibodies, or has overlapping features of paraneoplastic syndrome or several autoimmune neuropathies. Early specific autoantibody diagnosis and appropriate intervention, despite the initial cost of broader testing, may be cost effective in the longer term given the devastating nature of many of these diseases.

Specimen Requirements

Specimen

Serum (gel barrier tube or red-top tube)

Volume

2 mL

Minimum Volume

1 mL (Note: This volume does not allow for repeat testing.)

Container

Gel barrier tube, Serum transfer tube

Stability Requirements

TemperaturePeriod
Room temperature14 days
Refrigerated14 days
Frozen14 days
Freeze/thaw cyclesStable x3

Causes for Rejection

Gross hemolysis; grossly lipemic; gross icetrus

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
505500 Autoimmune Neurology Ab 505548 Interpretation 56850-1
505500 Autoimmune Neurology Ab 505241 Anti-Hu Ab 49738-8
505500 Autoimmune Neurology Ab 505243 Anti-Ri Ab 43187-4
505500 Autoimmune Neurology Ab 505469 Antineuronal nuclear Ab Type 3 43102-3
505500 Autoimmune Neurology Ab 505245 PCA Type-1 (Anti-Yo) Ab 84924-0
505500 Autoimmune Neurology Ab 505471 Purkinje Cell Cyto Ab Type 2 84925-7
505500 Autoimmune Neurology Ab 505472 Purkinje Cell Cyto Ab Type Tr 84926-5
505500 Autoimmune Neurology Ab 505470 Amphiphysin Antibody 33422-7
505500 Autoimmune Neurology Ab 505486 CRMP-5 IgG 43103-1
505500 Autoimmune Neurology Ab 505488 AGNA-1 84927-3
505500 Autoimmune Neurology Ab 505491 DPPX Antibody 82976-2
505500 Autoimmune Neurology Ab 505492 mGluR1 Antibody 94347-2
505500 Autoimmune Neurology Ab 505497 IgLON5 Antibody 96476-7
505500 Autoimmune Neurology Ab 505502 Ma2/Ta Antibody 35458-9
505500 Autoimmune Neurology Ab 505511 Zic4 Antibody 38915-5
505500 Autoimmune Neurology Ab 505513 DNER Antibody 84926-5
505500 Autoimmune Neurology Ab 505516 ITPR1 Antibody 96464-3
505500 Autoimmune Neurology Ab 505519 AMPA-R1 Antibody 84929-9
505500 Autoimmune Neurology Ab 505524 AMPA-R2 Antibody 84930-7
505500 Autoimmune Neurology Ab 505534 GABA-B-R Antibody 84931-5
505500 Autoimmune Neurology Ab 505536 NMDA-R Antibody 84928-1
505500 Autoimmune Neurology Ab 505537 GAD65 Antibody 94345-6
505500 Autoimmune Neurology Ab 505547 Aquaporin 4 Antibody 61430-5
505500 Autoimmune Neurology Ab 140686 VGCC Antibody pmol/L 31024-3
505500 Autoimmune Neurology Ab 505431 CASPR2 Antibody,Cell-based IFA 82979-6
505500 Autoimmune Neurology Ab 505356 LGI1 Antibody, Cell-based IFA 82978-8
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505548
Result Code NameInterpretation
UofM
Result LOINC56850-1
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505241
Result Code NameAnti-Hu Ab
UofM
Result LOINC49738-8
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505243
Result Code NameAnti-Ri Ab
UofM
Result LOINC43187-4
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505469
Result Code NameAntineuronal nuclear Ab Type 3
UofM
Result LOINC43102-3
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505245
Result Code NamePCA Type-1 (Anti-Yo) Ab
UofM
Result LOINC84924-0
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505471
Result Code NamePurkinje Cell Cyto Ab Type 2
UofM
Result LOINC84925-7
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505472
Result Code NamePurkinje Cell Cyto Ab Type Tr
UofM
Result LOINC84926-5
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505470
Result Code NameAmphiphysin Antibody
UofM
Result LOINC33422-7
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505486
Result Code NameCRMP-5 IgG
UofM
Result LOINC43103-1
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505488
Result Code NameAGNA-1
UofM
Result LOINC84927-3
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505491
Result Code NameDPPX Antibody
UofM
Result LOINC82976-2
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505492
Result Code NamemGluR1 Antibody
UofM
Result LOINC94347-2
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505497
Result Code NameIgLON5 Antibody
UofM
Result LOINC96476-7
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505502
Result Code NameMa2/Ta Antibody
UofM
Result LOINC35458-9
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505511
Result Code NameZic4 Antibody
UofM
Result LOINC38915-5
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505513
Result Code NameDNER Antibody
UofM
Result LOINC84926-5
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505516
Result Code NameITPR1 Antibody
UofM
Result LOINC96464-3
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505519
Result Code NameAMPA-R1 Antibody
UofM
Result LOINC84929-9
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505524
Result Code NameAMPA-R2 Antibody
UofM
Result LOINC84930-7
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505534
Result Code NameGABA-B-R Antibody
UofM
Result LOINC84931-5
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505536
Result Code NameNMDA-R Antibody
UofM
Result LOINC84928-1
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505537
Result Code NameGAD65 Antibody
UofM
Result LOINC94345-6
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505547
Result Code NameAquaporin 4 Antibody
UofM
Result LOINC61430-5
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code140686
Result Code NameVGCC Antibody
UofMpmol/L
Result LOINC31024-3
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505431
Result Code NameCASPR2 Antibody,Cell-based IFA
UofM
Result LOINC82979-6
Order Code505500
Order Code NameAutoimmune Neurology Ab
Order Loinc
Result Code505356
Result Code NameLGI1 Antibody, Cell-based IFA
UofM
Result LOINC82978-8
Reflex Table for Anti-Hu Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505242 Anti-Hu Ab Line Blot 505242 Anti-Hu Ab Line Blot 94389-4
Reflex 1
Order Code505242
Order NameAnti-Hu Ab Line Blot
Result Code505242
Result NameAnti-Hu Ab Line Blot
UofM
Result LOINC94389-4
Reflex Table for Anti-Ri Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505244 Anti-Ri Ab Line Blot 505244 Anti-Ri Ab Line Blot 94387-8
Reflex 1
Order Code505244
Order NameAnti-Ri Ab Line Blot
Result Code505244
Result NameAnti-Ri Ab Line Blot
UofM
Result LOINC94387-8
Reflex Table for PCA Type-1 (Anti-Yo) Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505246 Anti-Yo Ab Line Blot 505246 Anti-Yo Ab Line Blot 94271-4
Reflex 1
Order Code505246
Order NameAnti-Yo Ab Line Blot
Result Code505246
Result NameAnti-Yo Ab Line Blot
UofM
Result LOINC94271-4
Reflex Table for Purkinje Cell Cyto Ab Type Tr
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505473 PCA-Tr Line Blot 505473 PCA-Tr Line Blot 88734-9
Reflex 1
Order Code505473
Order NamePCA-Tr Line Blot
Result Code505473
Result NamePCA-Tr Line Blot
UofM
Result LOINC88734-9
Reflex Table for Amphiphysin Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505474 Amphiphysin Line Blot 505474 Amphiphysin Line Blot 94385-2
Reflex 1
Order Code505474
Order NameAmphiphysin Line Blot
Result Code505474
Result NameAmphiphysin Line Blot
UofM
Result LOINC94385-2
Reflex Table for CRMP-5 IgG
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505487 CRMP-5 IgG Line Blot 505487 CRMP-5 IgG Line Blot 47401-5
Reflex 1
Order Code505487
Order NameCRMP-5 IgG Line Blot
Result Code505487
Result NameCRMP-5 IgG Line Blot
UofM
Result LOINC47401-5
Reflex Table for AGNA-1
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505489 AGNA-1 Line Blot 505489 AGNA-1 Line Blot 82444-1
Reflex 1
Order Code505489
Order NameAGNA-1 Line Blot
Result Code505489
Result NameAGNA-1 Line Blot
UofM
Result LOINC82444-1
Reflex Table for DPPX Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505281 DPPX Cell-based IFA 505281 DPPX Cell-based IFA 94676-4
Reflex 1
Order Code505281
Order NameDPPX Cell-based IFA
Result Code505281
Result NameDPPX Cell-based IFA
UofM
Result LOINC94676-4
Reflex Table for mGluR1 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505493 mGluR1 Cell-based IFA 505493 mGluR1 Cell-based IFA 93498-4
Reflex 1
Order Code505493
Order NamemGluR1 Cell-based IFA
Result Code505493
Result NamemGluR1 Cell-based IFA
UofM
Result LOINC93498-4
Reflex Table for IgLON5 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505498 IgLON5 Cell-based IFA 505498 IgLON5 Cell-based IFA 96478-3
Reflex 1
Order Code505498
Order NameIgLON5 Cell-based IFA
Result Code505498
Result NameIgLON5 Cell-based IFA
UofM
Result LOINC96478-3
Reflex Table for Ma2/Ta Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505506 Ma2/Ta Line Blot 505506 Ma2/Ta Line Blot 82423-5
Reflex 1
Order Code505506
Order NameMa2/Ta Line Blot
Result Code505506
Result NameMa2/Ta Line Blot
UofM
Result LOINC82423-5
Reflex Table for Zic4 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505512 Zic4 Line Blot 505512 Zic4 Line Blot 101229-3
Reflex 1
Order Code505512
Order NameZic4 Line Blot
Result Code505512
Result NameZic4 Line Blot
UofM
Result LOINC101229-3
Reflex Table for DNER Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505514 DNER Line Blot 505514 DNER Line Blot 82999-4
Reflex 1
Order Code505514
Order NameDNER Line Blot
Result Code505514
Result NameDNER Line Blot
UofM
Result LOINC82999-4
Reflex Table for ITPR1 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505517 ITPR1 Cell-based IFA 505517 ITPR1 Cell-based IFA 96466-8
Reflex 1
Order Code505517
Order NameITPR1 Cell-based IFA
Result Code505517
Result NameITPR1 Cell-based IFA
UofM
Result LOINC96466-8
Reflex Table for AMPA-R1 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505521 AMPA-R-1 Cell-based IFA 505521 AMPA-R-1 Cell-based IFA 93869-6
Reflex 1
Order Code505521
Order NameAMPA-R-1 Cell-based IFA
Result Code505521
Result NameAMPA-R-1 Cell-based IFA
UofM
Result LOINC93869-6
Reflex Table for AMPA-R2 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505532 AMPA-R-2 Cell-based IFA 505532 AMPA-R-2 Cell-based IFA 93868-8
Reflex 1
Order Code505532
Order NameAMPA-R-2 Cell-based IFA
Result Code505532
Result NameAMPA-R-2 Cell-based IFA
UofM
Result LOINC93868-8
Reflex Table for GABA-B-R Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505267 GABA-B Receptor Cell-based IFA 505267 GABA-B Receptor Cell-based IFA 93867-0
Reflex 1
Order Code505267
Order NameGABA-B Receptor Cell-based IFA
Result Code505267
Result NameGABA-B Receptor Cell-based IFA
UofM
Result LOINC93867-0
Reflex Table for NMDA-R Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505376 NMDAR Antibody, Cell-based IFA 505376 NMDAR Antibody, Cell-based IFA 90839-2
Reflex 1
Order Code505376
Order NameNMDAR Antibody, Cell-based IFA
Result Code505376
Result NameNMDAR Antibody, Cell-based IFA
UofM
Result LOINC90839-2
Reflex Table for GAD65 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505546 GAD65 Line Blot 505546 GAD65 Line Blot 81725-4
Reflex 1
Order Code505546
Order NameGAD65 Line Blot
Result Code505546
Result NameGAD65 Line Blot
UofM
Result LOINC81725-4
Reflex Table for Aquaporin 4 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 004213 NMO IgG Autoantibodies 004213 NMO IgG Autoantibodies U/mL 68548-7
Reflex 1
Order Code004213
Order NameNMO IgG Autoantibodies
Result Code004213
Result NameNMO IgG Autoantibodies
UofMU/mL
Result LOINC68548-7
Reflex Table for CASPR2 Antibody,Cell-based IFA
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505432 Anti-CASPR2 Antibody Titer 505432 Anti-CASPR2 Antibody Titer 95600-3
Reflex 1
Order Code505432
Order NameAnti-CASPR2 Antibody Titer
Result Code505432
Result NameAnti-CASPR2 Antibody Titer
UofM
Result LOINC95600-3
Reflex Table for LGI1 Antibody, Cell-based IFA
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505357 Anti-LGI1 Antibody Titer,Serum 505357 Anti-LGI1 Antibody Titer,Serum 90831-9
Reflex 1
Order Code505357
Order NameAnti-LGI1 Antibody Titer,Serum
Result Code505357
Result NameAnti-LGI1 Antibody Titer,Serum
UofM
Result LOINC90831-9