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ReproSURE™ (Ovarian Reserve Profile)

CPT 82166; 82670; 83001
Synonyms
  • AMH
  • Anti Mullerian Hormone
  • assisted reproductive technology
  • E2
  • eggs
  • Estradiol
  • fertility
  • FSH
  • infertility
  • oocytes
  • ovarian reserve assessment
  • reproductive

Test Details

Methodology

Anti-Müllerian Hormone: Electrochemiluminescence; FSH: Electrochemiluminescence; Estradiol: LC-MS/MS

Result Turnaround Time

7 - 14 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

ReproSURE™ Ovarian Reserve Profile

Use

ReproSURE™ is a blood test comprised of Anti-Müllerian Hormone (AMH), Follicle Stimulating Hormone (FSH), and Estradiol designed to provide information about ovarian reserve. Ovarian reserve is a term used to describe a woman's reproductive potential, including the number of oocyttes (eggs) she possesses.

1. ReproSURE is a blood test comprised of AMH, FSH and Estradiol hormones designed to provide information about ovarian reserve.

2. While no laboratory test can predict pregnancy, these ovarian reserve tests assess oocyte quantity and help predict ovarian response to stimulation in order to individualize fertility options including assisted reproductive technology (ART) treatment.

3. Correct timing of blood collection is important. Serum specimen for ReproSURE testing should be collected on day 3 of your menstrual cycle. Day 2 or 4 collection may also be acceptable. FSH and estradiol levels rise and fluctuate after cycle day 3. If FSH and estradiol levels are higher than expected, you may wish to verify the cycle day of the blood collection.

4. These tests are not the sole criteria used to determine appropriateness of ART or any other treatment.

5. These tests do not evaluate egg quality. Egg quality peaks in a woman's twenties and then declines with age.

6. Antral follicle count (AFC) is another measure of egg supply that can be obtained by ultrasound observation.

Limitations

Blood sample should be collected on day 3 of menstrual cycle as target ranges for ovarian assessment are based on day 3 concentrations.

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

2.3 mL (Note: This volume does not allow for repeat testing.)

Container

Gel-barrier tube or red-top tube

Collection Instructions

Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection.

Stability Requirements

Temperature

Period

Room temperature

1 day

Refrigerated

7 days

Frozen

60 days

Freeze/thaw cycles

Stable x6

Storage Instructions

Refrigerate

Causes for Rejection

Gross hemolysis; lipemia; icteric specimen

References

Tal R, Seifer DB. Ovarian reserve testing: a user's guide. Am J Obstet Gynecol. 2017 Feb;1-12.2823546510.1016/j.ajog.2017.02.027
Practice Committee of the American Society for Reproductive Medicine (ASRM). Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2015 Mar;103(3):e9-e17.2558550510.1016/j.fertnstert.2014.12.093
Zegers-Hochschild F, Adamson GD, Dyer S, et al. The International Glossary on Infertility and Fertility Care, 2017. Fertil Steril. July 2017:1-15.2876051710.1016/j.fertnstert.2017.06.005
Leader B, Hegde A, Baca Q, et al. High frequency of discordance between antimullerian hormone and follicle stimulating hormone levels in serum from estradiol confirmed days 2 to 4 of the menstrual cycle from 5,354 women in U.S. fertility centers. Fertil Steril. 2012 Oct;98(4):1037-1042.2277102810.1016/j.fertnstert.2012.06.006

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
504295 ReproSURE 504585 Overview 77202-0
504295 ReproSURE 500184 Anti-Mullerian Hormone (AMH) ng/mL 38476-8
504295 ReproSURE 500098 Follicle Stimulating Hormone mIU/mL 15067-2
504295 ReproSURE 502608 Estradiol, Serum, MS pg/mL 35384-7
504295 ReproSURE 504586 Comments 75608-0
Order Code504295
Order Code NameReproSURE
Order Loinc
Result Code504585
Result Code NameOverview
UofM
Result LOINC77202-0
Order Code504295
Order Code NameReproSURE
Order Loinc
Result Code500184
Result Code NameAnti-Mullerian Hormone (AMH)
UofMng/mL
Result LOINC38476-8
Order Code504295
Order Code NameReproSURE
Order Loinc
Result Code500098
Result Code NameFollicle Stimulating Hormone
UofMmIU/mL
Result LOINC15067-2
Order Code504295
Order Code NameReproSURE
Order Loinc
Result Code502608
Result Code NameEstradiol, Serum, MS
UofMpg/mL
Result LOINC35384-7
Order Code504295
Order Code NameReproSURE
Order Loinc
Result Code504586
Result Code NameComments
UofM
Result LOINC75608-0
Reflex Table for Comments
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 910395 ReproSure Patient Education 910396 Note N/A
Reflex 1
Order Code910395
Order NameReproSure Patient Education
Result Code910396
Result NameNote
UofM
Result LOINCN/A
Reflex Table for Comments
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 910395 ReproSure Patient Education 910397 PDF N/A
Reflex 1
Order Code910395
Order NameReproSure Patient Education
Result Code910397
Result NamePDF
UofM
Result LOINCN/A