Test Details
Methodology
Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution.
Result Turnaround Time
3 - 7 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune uveitis that can lead to severe visual impairment. Greater than 95% of patients diagnosed with BSCR carry the human leukocyte antigen (HLA)A*29 allele of the major histocompatibility complex (MHC). The MHC family of genes code for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T cell receptors to elicit an immune response.
Special Instructions
If you have questions, please call 800-533-1037 (HLA customer service) for assistance selecting the proper HLA test for the patient.
Specimen Requirements
Limitations
The presence of HLA A*29 alone is not sufficient for a diagnosis of Birdshot Chorioretinopathy. Many individuals with HLA A*29 do not have the disease and some patients with the disease do not have HLA A*29.
This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).
References
Specimen
Whole blood
Volume
7 mL
Container
Lavender-top (EDTA) tube
Storage Instructions
Maintain whole blood specimen at room temperature.
Causes for Rejection
Hemolysis; clotted specimen
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 167390 | HLA-A29 Uveitis | 13298-5 | 167321 | HLA-A | 13298-5 | |
| 167390 | HLA-A29 Uveitis | 13298-5 | 167322 | HLA-A | 13298-5 | |
| 167390 | HLA-A29 Uveitis | 13298-5 | 167384 | HLA Methodology | 49549-9 | |
| Order Code | 167390 | |||||
| Order Code Name | HLA-A29 Uveitis | |||||
| Order Loinc | 13298-5 | |||||
| Result Code | 167321 | |||||
| Result Code Name | HLA-A | |||||
| UofM | ||||||
| Result LOINC | 13298-5 | |||||
| Order Code | 167390 | |||||
| Order Code Name | HLA-A29 Uveitis | |||||
| Order Loinc | 13298-5 | |||||
| Result Code | 167322 | |||||
| Result Code Name | HLA-A | |||||
| UofM | ||||||
| Result LOINC | 13298-5 | |||||
| Order Code | 167390 | |||||
| Order Code Name | HLA-A29 Uveitis | |||||
| Order Loinc | 13298-5 | |||||
| Result Code | 167384 | |||||
| Result Code Name | HLA Methodology | |||||
| UofM | ||||||
| Result LOINC | 49549-9 |