HLA-A29 Uveitis - Birdshot Chorioretinopathy

TEST: 167390
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CPT: 81381
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Synonyms

  • A*29
  • A29
  • Birdshot Retinochoroidopathy
  • BSRC
  • HLA A29
  • HLA-A29

Special Instructions

If you have questions, please call 800-533-1037 (HLA customer service) for assistance selecting the proper HLA test for the patient.

Expected Turnaround Time

3 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Specimen Requirements

Specimen

Whole blood

Volume

7 mL

Container

Lavender-top (EDTA) tube

Storage Instructions

Maintain whole blood specimen at room temperature.

Causes for Rejection

Hemolysis; clotted specimen

Test Details

Use

Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune uveitis that can lead to severe visual impairment. Greater than 95% of patients diagnosed with BSCR carry the human leukocyte antigen (HLA)A*29 allele of the major histocompatibility complex (MHC). The MHC family of genes code for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T cell receptors to elicit an immune response.

Limitations

The presence of HLA A*29 alone is not sufficient for a diagnosis of Birdshot Chorioretinopathy. Many individuals with HLA A*29 do not have the disease and some patients with the disease do not have HLA A*29.

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA).

Methodology

Sequence-based typing (SBT), sequence-specific oligonucleotide probes (SSOP), and/or sequence-specific primers (SSP) as needed to obtain the required resolution.

References

Levinson RD, Rajalingam R, Park MS, et al. Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy. Am J Ophthalmol. 2004 Oct;138(4):631-634.15488792
Nussenblatt RB, Mittal KK, Ryan S, Green WR, Maumenee AE. Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen. Am J Ophthalmol. 1982 Aug;94(2):147-158.6956239

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
167390 HLA-A29 Uveitis 13298-5 167321 HLA-A 13298-5
167390 HLA-A29 Uveitis 13298-5 167322 HLA-A 13298-5
167390 HLA-A29 Uveitis 13298-5 167384 HLA Methodology 49549-9

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