α1-Acid Glycoprotein

TEST: 123045
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CPT: 83883
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Synonyms

  • AAG
  • Alpha-1-Acid Glycoprotein

Expected Turnaround Time

4 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Specimen Requirements

Specimen

Serum or plasma

Volume

1 mL

Minimum Volume

0.4 mL

Container

Red-top tube, gel-barrier tube, or green-top (heparin) tube

Collection

Separate serum or plasma from red blood cells.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days (stability provided by manufacturer or literature reference)

Refrigerated

5 months (stability provided by manufacturer or literature reference)

Frozen

1 year (stability provided by manufacturer or literature reference)

Freeze/thaw cycles

Stable x1 (stability provided by manufacturer or literature reference)

Causes for Rejection

Gross lipemia that cannot be cleared by ultracentrifugation; heat-inactivated samples

Test Details

Use

This test is used to monitor acute-phase proteins associated with inflammatory conditions such as RA and malignant neoplasms.

Methodology

Immunologic

Reference Interval

See table.

Age

Male (mg/dL)

Female (mg/dL)

0 to 17 y

Not established

Not established

18 to 30 y

39−86

47−121

31 to 40 y

36−106

47−121

41 to 70 y

36–106

38–131

>70 y

46−142

31−131

Additional Information

As an acute-phase protein levels of α1-acid glycoprotein are elevated during infections as well as acute and chronic inflammatory processes (eg, Crohn's disease). In these cases a highly sensitive assessment of the condition of the patient can be obtained by preparing a prognostic index of α1-acid glycoprotein and other parameters such as CRP.1-3 Patients with injuries, burns, or tumors exhibit elevated concentrations. Patients with chronic renal failure are found to have high concentrations of α1-acid glycoprotein, with no major difference reported between dialyzed and nondialyzed patients. Diminished concentrations due to restricted production of α1-acid glycoprotein are found in patients with chronic liver diseases. Low serum concentrations due to increased excretion of the protein are associated with nephritic syndrome.4

Footnotes

1. Pressac M, Vignoli L, Aymard P, Ingenbleek Y. Usefulness of a prognostic inflammatory and nutritional index in pediatric clinical practice. Clin Chem Acta. 1990 Apr 30; 188(2):129-136.
2. Brignola C, Campieri M, Bazzocchi G, Farruggia P, Tragnone A, Lanfranchi GA. A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease. Gastroenterology. 1986 Dec; 91(6):1490-1494.
3. Ingenbleek Y, Carpentier YA. A prognostic inflammatory and nutritional index scoring critically ill patients. Int J Vitam Nutr Res. 1985; 55(1):91-101.
4. Routledge PA. Clinical relevance of alpha 1 acid glycoprotein in health and disease. Prog Clin Biol Res. 1989; 300:185-198.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
123045 Alpha-1-Acid Glycoprotein 2685-6 123046 Alpha-1-Acid Glycoprotein mg/dL 2685-6

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