Serum Integrated 2

Test Number 017270

Test number copied

CPT [MAAA: 81511] or 82105; 82677; 84702; 86336

Synonyms

AFP, Maternal Serum
Down Syndrome

Test Details

Methodology

Chemiluminescent immunoassay

Result Turnaround Time

2 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Serum Integrated 1

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. Patient must have submitted a previous specimen in the first trimester for the Serum Integrated 1 [017200] test. Gestational age will be based on information provided with the first trimester specimen. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition 0900. Testing is provided from 15.0 to 21.9 weeks of gestation.

Limitations

Serum integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the second trimester portion of the test. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

3 mL

Container

Gel-barrier tube

Collection Instructions

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.

Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.

Stability Requirements

Temperature	Period
Room temperature	7 days
Refrigerated	14 days
Frozen	14 days
Freeze/thaw cycles	Stable x3

Storage Instructions

Room temperature

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

References

Wald NJ, Watt HC, Hackshaw AK. Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. N Engl J Med. 1999 Aug 12; 341(7):461-467.10441601

LOINC® Map

Order Code	Order Code Name	Result Code	Result Code Name	UofM	Result LOINC
017270	Serum Integrated 2	017870	Results		N/A
017270	Serum Integrated 2	017271	Test Results:		49586-1
017270	Serum Integrated 2	017273	FIRST TRIMESTER SAMPLE		N/A
017270	Serum Integrated 2	017274	Collected On		33882-2
017270	Serum Integrated 2	017275	Gestational Age	weeks	18185-9
017270	Serum Integrated 2	017276	Weight	lbs	29463-7
017270	Serum Integrated 2	017277	SECOND TRIMESTER SAMPLE		N/A
017270	Serum Integrated 2	017278	Collected On		33882-2
017270	Serum Integrated 2	017279	Gestational Age	weeks	18185-9
017270	Serum Integrated 2	017294	Weight	lbs	29463-7
017270	Serum Integrated 2	017295	Gest. Age Based on		21299-3
017270	Serum Integrated 2	017296	Maternal Age at EDD	yr	43993-5
017270	Serum Integrated 2	017297	Race		21484-1
017270	Serum Integrated 2	017896	Insulin Dep Diabetes		44877-9
017270	Serum Integrated 2	017298	Number of Fetuses		11878-6
017270	Serum Integrated 2	018224	PAPP-A Value	ng/mL	48407-1
017270	Serum Integrated 2	017302	PAPP-A MoM		76348-2
017270	Serum Integrated 2	017262	AFP Value	ng/mL	1834-1
017270	Serum Integrated 2	017304	AFP MoM		23811-3
017270	Serum Integrated 2	017266	hCG Value	IU/mL	19080-1
017270	Serum Integrated 2	017306	hCG MoM		32166-1
017270	Serum Integrated 2	017268	uE3 Value	ng/mL	2250-9
017270	Serum Integrated 2	017308	uE3 MoM		21264-7
017270	Serum Integrated 2	017280	DIA Value	pg/mL	23883-2
017270	Serum Integrated 2	017310	DIA MoM		36904-1
017270	Serum Integrated 2	018110	Open Spina Bifida		48803-1
017270	Serum Integrated 2	018111	Down Syndrome		43995-0
017270	Serum Integrated 2	018112	Down Syndrome		49090-4
017270	Serum Integrated 2	018113	Trisomy 18		43994-3
017270	Serum Integrated 2	018114	Trisomy 18		47223-3
017270	Serum Integrated 2	017316	OSB Interpretation		49586-1
017270	Serum Integrated 2	017272	Down Syndrome Interpretation		49586-1
017270	Serum Integrated 2	017317	Trisomy 18 Interpretation		49586-1
017270	Serum Integrated 2	017318	Comments:		77202-0
017270	Serum Integrated 2	017858	Note:		N/A
017270	Serum Integrated 2	511933	PDF		11502-2
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017870
Result Code Name	Results
UofM
Result LOINC	N/A
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017271
Result Code Name	Test Results:
UofM
Result LOINC	49586-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017273
Result Code Name	FIRST TRIMESTER SAMPLE
UofM
Result LOINC	N/A
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017274
Result Code Name	Collected On
UofM
Result LOINC	33882-2
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017275
Result Code Name	Gestational Age
UofM	weeks
Result LOINC	18185-9
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017276
Result Code Name	Weight
UofM	lbs
Result LOINC	29463-7
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017277
Result Code Name	SECOND TRIMESTER SAMPLE
UofM
Result LOINC	N/A
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017278
Result Code Name	Collected On
UofM
Result LOINC	33882-2
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017279
Result Code Name	Gestational Age
UofM	weeks
Result LOINC	18185-9
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017294
Result Code Name	Weight
UofM	lbs
Result LOINC	29463-7
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017295
Result Code Name	Gest. Age Based on
UofM
Result LOINC	21299-3
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017296
Result Code Name	Maternal Age at EDD
UofM	yr
Result LOINC	43993-5
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017297
Result Code Name	Race
UofM
Result LOINC	21484-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017896
Result Code Name	Insulin Dep Diabetes
UofM
Result LOINC	44877-9
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017298
Result Code Name	Number of Fetuses
UofM
Result LOINC	11878-6
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	018224
Result Code Name	PAPP-A Value
UofM	ng/mL
Result LOINC	48407-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017302
Result Code Name	PAPP-A MoM
UofM
Result LOINC	76348-2
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017262
Result Code Name	AFP Value
UofM	ng/mL
Result LOINC	1834-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017304
Result Code Name	AFP MoM
UofM
Result LOINC	23811-3
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017266
Result Code Name	hCG Value
UofM	IU/mL
Result LOINC	19080-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017306
Result Code Name	hCG MoM
UofM
Result LOINC	32166-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017268
Result Code Name	uE3 Value
UofM	ng/mL
Result LOINC	2250-9
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017308
Result Code Name	uE3 MoM
UofM
Result LOINC	21264-7
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017280
Result Code Name	DIA Value
UofM	pg/mL
Result LOINC	23883-2
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017310
Result Code Name	DIA MoM
UofM
Result LOINC	36904-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	018110
Result Code Name	Open Spina Bifida
UofM
Result LOINC	48803-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	018111
Result Code Name	Down Syndrome
UofM
Result LOINC	43995-0
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	018112
Result Code Name	Down Syndrome
UofM
Result LOINC	49090-4
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	018113
Result Code Name	Trisomy 18
UofM
Result LOINC	43994-3
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	018114
Result Code Name	Trisomy 18
UofM
Result LOINC	47223-3
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017316
Result Code Name	OSB Interpretation
UofM
Result LOINC	49586-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017272
Result Code Name	Down Syndrome Interpretation
UofM
Result LOINC	49586-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017317
Result Code Name	Trisomy 18 Interpretation
UofM
Result LOINC	49586-1
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017318
Result Code Name	Comments:
UofM
Result LOINC	77202-0
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	017858
Result Code Name	Note:
UofM
Result LOINC	N/A
Order Code	017270
Order Code Name	Serum Integrated 2
Order Loinc
Result Code	511933
Result Code Name	PDF
UofM
Result LOINC	11502-2

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