Serum Integrated 2

TEST: 017270
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CPT: [MAAA: 81511] or 82105; 82677; 84702; 86336
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Synonyms

  • AFP, Maternal Serum
  • Down Syndrome

Special Instructions

For test inquiries, call CMBP genetic services at 800-345-4363. Patient must have submitted a previous specimen in the first trimester for the Serum Integrated 1 [017200] test. Gestational age will be based on information provided with the first trimester specimen. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition 0900. Testing is provided from 15.0 to 21.9 weeks of gestation.

Expected Turnaround Time

2 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

3 mL

Container

Gel-barrier tube

Collection

Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.

Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type

Test Details

Use

Screening test for open neural tube defects, Down syndrome, and trisomy 18

Limitations

Serum integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the second trimester portion of the test. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Chemiluminescent immunoassay

References

Wald NJ, Watt HC, Hackshaw AK. Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. N Engl J Med. 1999 Aug 12; 341(7):461-467.10441601

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
017270 Serum Integrated 2 017870 Results N/A
017270 Serum Integrated 2 017271 Test Results: 49586-1
017270 Serum Integrated 2 017273 FIRST TRIMESTER SAMPLE N/A
017270 Serum Integrated 2 017274 Collected On 33882-2
017270 Serum Integrated 2 017275 Gestational Age weeks 18185-9
017270 Serum Integrated 2 017276 Weight lbs 29463-7
017270 Serum Integrated 2 017277 SECOND TRIMESTER SAMPLE N/A
017270 Serum Integrated 2 017278 Collected On 33882-2
017270 Serum Integrated 2 017279 Gestational Age weeks 18185-9
017270 Serum Integrated 2 017294 Weight lbs 29463-7
017270 Serum Integrated 2 017295 Gest. Age Based on 21299-3
017270 Serum Integrated 2 017296 Maternal Age at EDD yr 43993-5
017270 Serum Integrated 2 017297 Race 21484-1
017270 Serum Integrated 2 017896 Insulin Dep Diabetes 44877-9
017270 Serum Integrated 2 017298 Number of Fetuses 11878-6
017270 Serum Integrated 2 018224 PAPP-A Value ng/mL 48407-1
017270 Serum Integrated 2 017302 PAPP-A MoM 76348-2
017270 Serum Integrated 2 017262 AFP Value ng/mL 1834-1
017270 Serum Integrated 2 017304 AFP MoM 23811-3
017270 Serum Integrated 2 017266 hCG Value IU/mL 19080-1
017270 Serum Integrated 2 017306 hCG MoM 32166-1
017270 Serum Integrated 2 017268 uE3 Value ng/mL 2250-9
017270 Serum Integrated 2 017308 uE3 MoM 21264-7
017270 Serum Integrated 2 017280 DIA Value pg/mL 23883-2
017270 Serum Integrated 2 017310 DIA MoM 36904-1
017270 Serum Integrated 2 018110 Open Spina Bifida 48803-1
017270 Serum Integrated 2 018111 Down Syndrome 43995-0
017270 Serum Integrated 2 018112 Down Syndrome 49090-4
017270 Serum Integrated 2 018113 Trisomy 18 43994-3
017270 Serum Integrated 2 018114 Trisomy 18 47223-3
017270 Serum Integrated 2 017316 OSB Interpretation 49586-1
017270 Serum Integrated 2 017272 Down Syndrome Interpretation 49586-1
017270 Serum Integrated 2 017317 Trisomy 18 Interpretation 49586-1
017270 Serum Integrated 2 017318 Comments: 77202-0
017270 Serum Integrated 2 017858 Note: N/A
017270 Serum Integrated 2 511933 PDF 11502-2

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