Test Details
Methodology
Chemiluminescent immunoassay
Result Turnaround Time
2 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Screening test for open neural tube defects, Down syndrome, and trisomy 18
Special Instructions
For test inquiries, call CMBP genetic services at 800-345-4363. The following information must be provided: gestational age, date on which the patient was the stated gestational age, how gestational age was determined (LMP, EDD, US), patient's race, patient's weight, patient's date of birth, patient's insulin-dependent diabetic status, and the number of fetuses. Also indicate patient history (i.e. prior Down syndrome pregnancy, ultrasound anomalies). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition 0900. Testing provided from 10.0 to 14.0 weeks of gestation.
Limitations
Serum integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the first trimester portion of the test. Result interpretation will be provided only when the second trimester specimen is received and tested. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Gel-barrier tube
Collection Instructions
Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.
Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 017200 | Serum Integrated 1 | 017864 | Results | N/A | ||
| 017200 | Serum Integrated 1 | 017201 | Test Results: | 49586-1 | ||
| 017200 | Serum Integrated 1 | 017204 | Submit Part 2 Sample Using | N/A | ||
| 017200 | Serum Integrated 1 | 017205 | Gestational Age | weeks | 18185-9 | |
| 017200 | Serum Integrated 1 | 017206 | Gest. Age Based on | 21299-3 | ||
| 017200 | Serum Integrated 1 | 017207 | Maternal Age at EDD | yr | 43993-5 | |
| 017200 | Serum Integrated 1 | 017208 | Race | 21484-1 | ||
| 017200 | Serum Integrated 1 | 017209 | Weight | lbs | 29463-7 | |
| 017200 | Serum Integrated 1 | 017291 | Number of Fetuses | 11878-6 | ||
| 017200 | Serum Integrated 1 | 018219 | PAPP-A Value | ng/mL | 48407-1 | |
| 017200 | Serum Integrated 1 | 017293 | Comments: | 77202-0 | ||
| 017200 | Serum Integrated 1 | 017857 | Note: | N/A | ||
| 017200 | Serum Integrated 1 | 511933 | 11502-2 | |||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017864 | |||||
| Result Code Name | Results | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017201 | |||||
| Result Code Name | Test Results: | |||||
| UofM | ||||||
| Result LOINC | 49586-1 | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017204 | |||||
| Result Code Name | Submit Part 2 Sample Using | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017205 | |||||
| Result Code Name | Gestational Age | |||||
| UofM | weeks | |||||
| Result LOINC | 18185-9 | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017206 | |||||
| Result Code Name | Gest. Age Based on | |||||
| UofM | ||||||
| Result LOINC | 21299-3 | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017207 | |||||
| Result Code Name | Maternal Age at EDD | |||||
| UofM | yr | |||||
| Result LOINC | 43993-5 | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017208 | |||||
| Result Code Name | Race | |||||
| UofM | ||||||
| Result LOINC | 21484-1 | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017209 | |||||
| Result Code Name | Weight | |||||
| UofM | lbs | |||||
| Result LOINC | 29463-7 | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017291 | |||||
| Result Code Name | Number of Fetuses | |||||
| UofM | ||||||
| Result LOINC | 11878-6 | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 018219 | |||||
| Result Code Name | PAPP-A Value | |||||
| UofM | ng/mL | |||||
| Result LOINC | 48407-1 | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017293 | |||||
| Result Code Name | Comments: | |||||
| UofM | ||||||
| Result LOINC | 77202-0 | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 017857 | |||||
| Result Code Name | Note: | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 017200 | |||||
| Order Code Name | Serum Integrated 1 | |||||
| Order Loinc | ||||||
| Result Code | 511933 | |||||
| Result Code Name | ||||||
| UofM | ||||||
| Result LOINC | 11502-2 |