Find Locations
For hours, walk-ins and appointments.Synonyms
- Down Syndrome
- PAPP-A
Special Instructions
For test inquiries, call CMBP genetic services at 800-345-4363. The following information must be provided: gestational age, date on which the patient was the stated gestational age, how gestational age was determined (LMP, EDD, US), patient's race, patient's weight, patient's date of birth, patient's insulin-dependent diabetic status, and the number of fetuses. Also indicate patient history (i.e. prior Down syndrome pregnancy, ultrasound anomalies). Complete information is necessary to interpret the test. Patient information may be provided to the laboratory using the Maternal Prenatal Screening requisition 0900. Testing provided from 10.0 to 14.0 weeks of gestation.
Expected Turnaround Time
2 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Gel-barrier tube
Collection
Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory.
Pour-off is not advised. Maternal serum specimens must be drawn prior to amniocentesis to avoid contamination with fetal blood.
Storage Instructions
Room temperature
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type
Test Details
Use
Screening test for open neural tube defects, Down syndrome, and trisomy 18
Limitations
Serum integrated screening requires two specimens: one collected in the first trimester and one in the second trimester. This test number is for the first trimester portion of the test. Result interpretation will be provided only when the second trimester specimen is received and tested. This is a screening test. A positive result means that diagnostic testing may be offered to the pregnant woman to determine if a neural tube defect or chromosome abnormality is present.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Chemiluminescent immunoassay
References
Wald NJ, Watt HC, Hackshaw AK. Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. N Engl J Med. 1999 Aug 12; 341(7):461-467. 10441601
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 017200 | Serum Integrated 1 | 017864 | Results | N/A | ||
| 017200 | Serum Integrated 1 | 017201 | Test Results: | 49586-1 | ||
| 017200 | Serum Integrated 1 | 017204 | Submit Part 2 Sample Using | N/A | ||
| 017200 | Serum Integrated 1 | 017205 | Gestational Age | weeks | 18185-9 | |
| 017200 | Serum Integrated 1 | 017206 | Gest. Age Based on | 21299-3 | ||
| 017200 | Serum Integrated 1 | 017207 | Maternal Age at EDD | yr | 43993-5 | |
| 017200 | Serum Integrated 1 | 017208 | Race | 21484-1 | ||
| 017200 | Serum Integrated 1 | 017209 | Weight | lbs | 29463-7 | |
| 017200 | Serum Integrated 1 | 017291 | Number of Fetuses | 11878-6 | ||
| 017200 | Serum Integrated 1 | 018219 | PAPP-A Value | ng/mL | 48407-1 | |
| 017200 | Serum Integrated 1 | 017293 | Comments: | 77202-0 | ||
| 017200 | Serum Integrated 1 | 017857 | Note: | N/A | ||
| 017200 | Serum Integrated 1 | 511933 | 11502-2 |
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf