Test Details
Methodology
Inductively-coupled plasma/mass spectrometry (ICP/MS)
Result Turnaround Time
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Creatinine, urine; zinc, urine; zinc:creatinine ratio; zinc, urine (24-hour)
Use
Evaluate zinc exposure; evaluate low serum zinc levels; evaluate compliance in oral zinc therapy of Wilson disease.2 Low urine zinc levels in the presence of depressed serum zinc tends to confirm zinc deficiency.
Special Instructions
If 24-hour urine is submitted, then request form must state 24-hour collection volume. Do not use preservative. Preservatives used for routine analysis may contain mercuric oxide (ie, Stabilur), which interferes with all metal testing. If both urinalysis and metal testing are ordered, please submit a separate urine specimen (containing no additive) for the metal testing.
Limitations
Zinc deficiency is usually accompanied by decreased urine zinc excretion. Zinc deficiency, however, may be in part due to excess urine losses, especially in cirrhosis, hemolytic anemias, sickle cell disease, alcoholism, diabetes, or chronic renal diseases.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Footnotes
Custom Additional Information
Zinc poisoning through inhalation of zinc oxide fumes or dust often produces symptoms of respiratory tract irritation, chest pain and cough, fatigue, headache, nausea, fever, and muscle pain.3 Zinc is utilized as an alloying agent in brass and other metals, as well as in metal plating. Zinc chloride is often produced in the chemical smoke generators that are employed in industry. Zinc chloride is also used in soldering fluxes and wood preservatives.
Specimen Requirements
Specimen
Urine (24-hour or random)
Volume
5 mL
Minimum Volume
1.7 mL (Note: This volume does not allow for repeat testing.)
Container
Plastic urine container, no preservative
Collection Instructions
Optional protocol: Instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Screw the lid on securely.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
Environmental exposure: 100−900 μg/g creatinine,1 150−1200 μg/24 hours
Storage Instructions
Maintain specimen at room temperature.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 003434 | Zinc, Urine | 21610-1 | 019398 | Zinc, Urine | ug/L | 21610-1 |
| 003434 | Zinc, Urine | 21610-1 | 723280 | Creatinine(Crt),U | g/L | 2161-8 |
| 003434 | Zinc, Urine | 21610-1 | 019399 | Zinc/Creat. Ratio | ug/g creat | 13473-4 |
| 003434 | Zinc, Urine | 21610-1 | 019349 | Zinc, Urine (24 hr) | ug/24 hr | 5765-3 |
| Order Code | 003434 | |||||
| Order Code Name | Zinc, Urine | |||||
| Order Loinc | 21610-1 | |||||
| Result Code | 019398 | |||||
| Result Code Name | Zinc, Urine | |||||
| UofM | ug/L | |||||
| Result LOINC | 21610-1 | |||||
| Order Code | 003434 | |||||
| Order Code Name | Zinc, Urine | |||||
| Order Loinc | 21610-1 | |||||
| Result Code | 723280 | |||||
| Result Code Name | Creatinine(Crt),U | |||||
| UofM | g/L | |||||
| Result LOINC | 2161-8 | |||||
| Order Code | 003434 | |||||
| Order Code Name | Zinc, Urine | |||||
| Order Loinc | 21610-1 | |||||
| Result Code | 019399 | |||||
| Result Code Name | Zinc/Creat. Ratio | |||||
| UofM | ug/g creat | |||||
| Result LOINC | 13473-4 | |||||
| Order Code | 003434 | |||||
| Order Code Name | Zinc, Urine | |||||
| Order Loinc | 21610-1 | |||||
| Result Code | 019349 | |||||
| Result Code Name | Zinc, Urine (24 hr) | |||||
| UofM | ug/24 hr | |||||
| Result LOINC | 5765-3 |