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Expected Turnaround Time
2 - 4 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
Specimen Requirements
Specimen
Plasma (preferred) or serum
Volume
1 mL
Minimum Volume
0.4 mL
Container
Royal blue-top (EDTA) tube or royal blue-top tube without EDTA
Collection
Separate serum from cells within 45 minutes of collection, and transfer to a certified metal-free transport tube (PeopleSoft N° 111166) for shipment to the laboratory. Plasma may be separated immediately and transferred to a certified metal-free plastic transport tube (PeopleSoft N° 111166) for shipment to the laboratory.
Storage Instructions
Maintain specimen at room temperature.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 28 days |
Refrigerated | 28 days |
Frozen | 28 days |
Freeze/thaw cycles | Stable x4 |
Causes for Rejection
Certified metal-free plastic transport tube not submitted; unspun royal blue-top tube from which the plasma or serum has not been removed; gel-barrier tube
Test Details
Use
Monitor exposure to zinc; evaluate suspected nutritional inadequacy (especially in enteral or parental nutrition, critically ill or burn patients); cases of diabetes or delayed wound healing; growth retardation; follow therapy (for example, when higher intravenous zinc doses are used to balance excessive ongoing GI losses in long-term total parenteral nutrition); follow oral zinc therapy in Wilson's disease; confirm acrodermatitis enteropathica and follow therapy
Limitations
Levels may be low in fever, sepsis, estrogen therapy, stress, or myocardial infarction, reflecting mobilization from serum to the liver by interleukin. Levels are usually low in uremia with normal tissue levels. Levels may be high in familial hyperzincemia without toxicity or high zinc stores.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Inductively coupled plasma/mass spectrometry (ICP/MS)
Reference Interval
Age | Male | Female |
|---|---|---|
0 to 2 m | 50–123 | 50–123 |
3 to 4 m | 44–133 | 51–124 |
5 to 10 m | 49–134 | 49–134 |
≥11 m | 44–115 | 44–115 |
Additional Information
Chronic oral zinc supplementation interferes with copper absorption and may precipitate copper deficiency. Albumin is the primary zinc binding protein: zinc levels should be interpreted with awareness of serum albumin level.
References
Alfrey AC. Essential trace elements. In Seldin DW, Giebisch G, eds. The Kidney: Physiology and Pathophysiology. 2nd ed. New York, NY: Raven Press Ltd;1992:2993-3003.
Ruz M, Cavan KR, Bettger WJ, et al. Development of a dietary model for the study of mild zinc deficiency in humans and evaluation of some biochemical and functional indices of zinc status. Am J Clin Nutr. 1991; 53(5):1295-1303.2021137
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 001800 | Zinc, Plasma or Serum | 5763-8 | 001800 | Zinc, Plasma or Serum | ug/dL | 5763-8 |
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf