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Synonyms
- AMH
- Anti Mullerian Hormone
- assisted reproductive technology
- E2
- eggs
- Estradiol
- fertility
- FSH
- infertility
- oocytes
- ovarian reserve assessment
- reproductive
Expected Turnaround Time
7 - 14 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Information
Related Documents
For more information, please view the literature below.
Specimen Requirements
Specimen
Serum
Volume
5 mL
Minimum Volume
2.3 mL (Note: This volume does not allow for repeat testing.)
Container
Gel-barrier tube or red-top tube
Collection
Allow a minimum clotting time of 30 to 60 minutes with serum separation within 2 hours of collection.
Storage Instructions
Refrigerate
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 1 day |
Refrigerated | 7 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x6 |
Causes for Rejection
Gross hemolysis; lipemia; icteric specimen
Test Details
Use
ReproSURE™ is a blood test comprised of Anti-Müllerian Hormone (AMH), Follicle Stimulating Hormone (FSH), and Estradiol designed to provide information about ovarian reserve. Ovarian reserve is a term used to describe a woman's reproductive potential, including the number of oocyttes (eggs) she possesses.
1. ReproSURE is a blood test comprised of AMH, FSH and Estradiol hormones designed to provide information about ovarian reserve.
2. While no laboratory test can predict pregnancy, these ovarian reserve tests assess oocyte quantity and help predict ovarian response to stimulation in order to individualize fertility options including assisted reproductive technology (ART) treatment.
3. Correct timing of blood collection is important. Serum specimen for ReproSURE testing should be collected on day 3 of your menstrual cycle. Day 2 or 4 collection may also be acceptable. FSH and estradiol levels rise and fluctuate after cycle day 3. If FSH and estradiol levels are higher than expected, you may wish to verify the cycle day of the blood collection.
4. These tests are not the sole criteria used to determine appropriateness of ART or any other treatment.
5. These tests do not evaluate egg quality. Egg quality peaks in a woman's twenties and then declines with age.
6. Antral follicle count (AFC) is another measure of egg supply that can be obtained by ultrasound observation.
Limitations
Blood sample should be collected on day 3 of menstrual cycle as target ranges for ovarian assessment are based on day 3 concentrations.
Methodology
Anti-Müllerian Hormone: Electrochemiluminescence; FSH: Electrochemiluminescence; Estradiol: LC-MS/MS
References
Tal R, Seifer DB. Ovarian reserve testing: a user's guide. Am J Obstet Gynecol. 2017 Feb;1-12.2823546510.1016/j.ajog.2017.02.027
Practice Committee of the American Society for Reproductive Medicine (ASRM). Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2015 Mar;103(3):e9-e17.2558550510.1016/j.fertnstert.2014.12.093
Zegers-Hochschild F, Adamson GD, Dyer S, et al. The International Glossary on Infertility and Fertility Care, 2017. Fertil Steril. July 2017:1-15.2876051710.1016/j.fertnstert.2017.06.005
Leader B, Hegde A, Baca Q, et al. High frequency of discordance between antimullerian hormone and follicle stimulating hormone levels in serum from estradiol confirmed days 2 to 4 of the menstrual cycle from 5,354 women in U.S. fertility centers. Fertil Steril. 2012 Oct;98(4):1037-1042.2277102810.1016/j.fertnstert.2012.06.006
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 504295 | ReproSURE | 504585 | Overview | 77202-0 | ||
| 504295 | ReproSURE | 500184 | Anti-Mullerian Hormone (AMH) | ng/mL | 38476-8 | |
| 504295 | ReproSURE | 500098 | Follicle Stimulating Hormone | mIU/mL | 15067-2 | |
| 504295 | ReproSURE | 502608 | Estradiol, Serum, MS | pg/mL | 35384-7 | |
| 504295 | ReproSURE | 504586 | Comments | 75608-0 |
| Reflex Table for Comments | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 910395 | ReproSure Patient Education | 910396 | Note | N/A | |
| Reflex Table for Comments | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 910395 | ReproSure Patient Education | 910397 | N/A | ||
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