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Nontuberculous Slowly-growing Mycobacterium Susceptibility−Broth Dilution

Test Number 182923
Test number copied
CPT 87186
Synonyms
  • M kansasii Susceptibility Testing
  • AFB Susceptibility Testing
  • MOTT Susceptibility Testing
  • Slow-grower Susceptibility Testing

Test Details

Methodology

Sensititre® broth microdilution (MIC)

Result Turnaround Time

35 - 40 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

Test Includes

Susceptibility testing for amikacin, ciprofloxacin, clarithromycin, doxycycline, linezolid, minocycline, moxifloxacin, rifabutin, rifampin, streptomycin and trimethoprim/sulfamethoxazole

Use

Determine the susceptibility of nontuberculous slowly-growing mycobacterial isolates to a profile of antimycobacterial agents. Clinical breakpoints for M. kansasii and Nontuberculosis Mycobacteria other than M. avium Complex are the same. Some fastidious isolates may not exhibit adequate growth for susceptibility testing (M. genvense, M. haemophilum). Others such as M. gordonae are rarely clinically relevant and susceptibility testing is not recommended. If patients are not responding to several months of therapy, repeat susceptibility testing is recommended.

Limitations

Susceptibilities cannot be reported if the organism fails to grow in the test medium. Susceptibilities cannot be performed on mixed cultures. An organism identification is required prior to reporting susceptibility results.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

References

Clinical Laboratory Standards Institute (CLSI). Performance Standards for Susceptibility Testing of Mycobacteria, Nocardia spp., and Other Aerobic Actinomycetes. 1st ed. CLSI supplement M62. Wayne, PA: CLSI; 2018.
Clinical Laboratory Standards Institute (CLSI). Susceptibility Testing of Mycobacteria, Nocardia spp., and Other Aerobic Actinomycetes. 3rd ed. CLSI standard M24. Wayne, PA: CLSI; 2018.
Griffith DE, Aksamit T, Brown-Elliott BA, et al. An official ATS/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416.17277290
Woods GL, Lin SYG, Brown BA, Desmond EP. Susceptibility Test Methods: Mycobacteria, Nocardia and Other Actinomycetes. Manual of Clinical Microbiology, 12th ed. 2018; 78:1398-1419.

Specimen Requirements

Specimen

Slowly-growing mycobacteria, other than M. tuberculosis or M. avium, isolated from a primary clinical specimen, on a submitted AFB conventional solid medium, or an AFB broth medium

Volume

Pure culture isolate on an AFB conventional solid medium or a minimum of 1 mL of AFB broth medium

Container

Conventional or broth medium, tightly sealed, in etiologic agent packaging

Storage Instructions

Maintain media at room temperature.

Causes for Rejection

Specimen received in leaking or in broken transport tube or vial; specimen received in expired transport medium; mixed culture; unlabeled culture or name discrepancy between specimen and request label

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
182923 Slow Grower Broth Suscep. 29579-0 182924 Organism ID 40699-1
182923 Slow Grower Broth Suscep. 29579-0 998568 Amikacin 5-Dec
182923 Slow Grower Broth Suscep. 29579-0 998569 Ciprofloxacin 185-9
182923 Slow Grower Broth Suscep. 29579-0 998570 Clarithromycin 189-1
182923 Slow Grower Broth Suscep. 29579-0 998243 Clofazimine 16623-1
182923 Slow Grower Broth Suscep. 29579-0 998214 Doxycycline 225-3
182923 Slow Grower Broth Suscep. 29579-0 998572 Linezolid 29254-0
182923 Slow Grower Broth Suscep. 29579-0 998769 Minocycline 335-0
182923 Slow Grower Broth Suscep. 29579-0 998573 Moxifloxacin 31037-5
182923 Slow Grower Broth Suscep. 29579-0 998215 Rifabutin 16100-0
182923 Slow Grower Broth Suscep. 29579-0 998574 Rifampin 428-3
182923 Slow Grower Broth Suscep. 29579-0 998576 Streptomycin 460-6
182923 Slow Grower Broth Suscep. 29579-0 998577 Trimethoprim/Sulfa 516-5
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code182924
Result Code NameOrganism ID
UofM
Result LOINC40699-1
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998568
Result Code NameAmikacin
UofM
Result LOINC5-Dec
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998569
Result Code NameCiprofloxacin
UofM
Result LOINC185-9
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998570
Result Code NameClarithromycin
UofM
Result LOINC189-1
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998243
Result Code NameClofazimine
UofM
Result LOINC16623-1
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998214
Result Code NameDoxycycline
UofM
Result LOINC225-3
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998572
Result Code NameLinezolid
UofM
Result LOINC29254-0
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998769
Result Code NameMinocycline
UofM
Result LOINC335-0
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998573
Result Code NameMoxifloxacin
UofM
Result LOINC31037-5
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998215
Result Code NameRifabutin
UofM
Result LOINC16100-0
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998574
Result Code NameRifampin
UofM
Result LOINC428-3
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998576
Result Code NameStreptomycin
UofM
Result LOINC460-6
Order Code182923
Order Code NameSlow Grower Broth Suscep.
Order Loinc29579-0
Result Code998577
Result Code NameTrimethoprim/Sulfa
UofM
Result LOINC516-5
Reflex Table for Organism ID
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 000000 Antimicrobial Susceptibility 000000 Antimicrobial Susceptibility N/A
Reflex 1
Order Code000000
Order NameAntimicrobial Susceptibility
Result Code000000
Result NameAntimicrobial Susceptibility
UofM
Result LOINCN/A