Test Details
Methodology
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Result Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Diagnosis of glycine encephalopathy (nonketotic hyperglycinemia).
Special Instructions
For plasma and cerebrospinal fluid collected more than 20 minutes, order Amino Acid Profile, Quantitative, Plasma (700068) or Amino Acid Profile, Quantitative, Cerebrospinal Fluid (700180). To discuss amino acid testing options, please call 1-800-345-GENE and ask to speak to a Biochemical Geneticist.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
References
Specimen Requirements
Specimen
Plasma, frozen and cerebrospinal fluid (CSF), frozen
Volume
0.5 mL plasma and 0.5 mL CSF
Minimum Volume
0.15 mL plasma and 0.15 mL CSF (Note: This volume does not allow for repeat testing.)
Container
Preferred: Frozen plasma from green-top (sodium heparin) tube and CSF: plastic transport tube, no preservative. Acceptable: Frozen plasma from green-top (lithium heparin) tube, frozen plasma from lavender-top (EDTA) tube or frozen plasma from PPT™. Frozen serum from serum separator tube (SST) or frozen serum from red-top tube will not be rejected. Note: Plasma reference ranges will be applied to all specimen types.
Collection Instructions
Plasma and CSF should be simultaneously collected (venipuncture immediately prior to lumbar puncture). Separate plasma from cells. Transfer specimen to plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | Unstable |
Refrigerated | Unstable |
Frozen | 14 days |
Reference Range
See Plasma Amino Acid Reference Intervals and also Cerebrospinal Amino Acid Reference Intervals in the Test Resources pages online.
Storage Instructions
Plasma: Centrifuge, remove plasma from cells, and freeze immediately, CSF: freeze immediately.
Causes for Rejection
Gross hemolysis; room temperature or thawed specimen; specimens collected in ACD (yellow-top) tubes
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 700200 | Amino Acids, Glycine, Pl + CSF | 73913-6 | 700508 | Glycine Plasma | umol/L | 20644-1 |
| 700200 | Amino Acids, Glycine, Pl + CSF | 73913-6 | 700509 | Glycine CSF | umol/L | 22650-6 |
| 700200 | Amino Acids, Glycine, Pl + CSF | 73913-6 | 700512 | CSF:Plasma | 73913-6 | |
| 700200 | Amino Acids, Glycine, Pl + CSF | 73913-6 | 700164 | Interpretation | 49303-1 | |
| 700200 | Amino Acids, Glycine, Pl + CSF | 73913-6 | 700165 | Director Review | 72486-4 | |
| 700200 | Amino Acids, Glycine, Pl + CSF | 73913-6 | 700166 | Methodology | 49549-9 | |
| 700200 | Amino Acids, Glycine, Pl + CSF | 73913-6 | 700471 | Disclaimer: | N/A | |
| Order Code | 700200 | |||||
| Order Code Name | Amino Acids, Glycine, Pl + CSF | |||||
| Order Loinc | 73913-6 | |||||
| Result Code | 700508 | |||||
| Result Code Name | Glycine Plasma | |||||
| UofM | umol/L | |||||
| Result LOINC | 20644-1 | |||||
| Order Code | 700200 | |||||
| Order Code Name | Amino Acids, Glycine, Pl + CSF | |||||
| Order Loinc | 73913-6 | |||||
| Result Code | 700509 | |||||
| Result Code Name | Glycine CSF | |||||
| UofM | umol/L | |||||
| Result LOINC | 22650-6 | |||||
| Order Code | 700200 | |||||
| Order Code Name | Amino Acids, Glycine, Pl + CSF | |||||
| Order Loinc | 73913-6 | |||||
| Result Code | 700512 | |||||
| Result Code Name | CSF:Plasma | |||||
| UofM | ||||||
| Result LOINC | 73913-6 | |||||
| Order Code | 700200 | |||||
| Order Code Name | Amino Acids, Glycine, Pl + CSF | |||||
| Order Loinc | 73913-6 | |||||
| Result Code | 700164 | |||||
| Result Code Name | Interpretation | |||||
| UofM | ||||||
| Result LOINC | 49303-1 | |||||
| Order Code | 700200 | |||||
| Order Code Name | Amino Acids, Glycine, Pl + CSF | |||||
| Order Loinc | 73913-6 | |||||
| Result Code | 700165 | |||||
| Result Code Name | Director Review | |||||
| UofM | ||||||
| Result LOINC | 72486-4 | |||||
| Order Code | 700200 | |||||
| Order Code Name | Amino Acids, Glycine, Pl + CSF | |||||
| Order Loinc | 73913-6 | |||||
| Result Code | 700166 | |||||
| Result Code Name | Methodology | |||||
| UofM | ||||||
| Result LOINC | 49549-9 | |||||
| Order Code | 700200 | |||||
| Order Code Name | Amino Acids, Glycine, Pl + CSF | |||||
| Order Loinc | 73913-6 | |||||
| Result Code | 700471 | |||||
| Result Code Name | Disclaimer: | |||||
| UofM | ||||||
| Result LOINC | N/A |