700068: Amino Acid Profile, Quantitative, Plasma

Test Details

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

Result Turnaround Time

3 - 6 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Amino Acid Test Options

Use

Diagnosis and monitoring of inherited aminoacidurias, organic acidurias, and urea cycle defects. May be used as a follow-up confirmatory test to some abnormal newborn screen results.

Limitations

False-negative results can occur, especially when a patient is affected with a mild or intermittent variant of a disorder or when clinical condition or dietary treatment causes secondary changes to the profile. Results of amino acid profiling should be interpreted in the context of clinical presentation, as well as other laboratory tests. Frozen serum may be diagnostic, however, certain amino acids may be falsely elevated or low.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

References

Bremer HJ, Duran M, Kamerling JP, et al. Disturbances of Amino Acid Metabolism: Clinical Chemistry and Diagnosis. Baltimore, Md: Urban and Schwarzenberg; 1981.

Specimen Requirements

Specimen

Plasma, frozen

Volume

0.5 mL

Minimum Volume

0.15 mL (Note: This volume does not allow for repeat testing.)

Container

Preferred: Frozen plasma from green-top (sodium heparin) tube. Acceptable: Frozen plasma from green-top (lithium heparin) tube, frozen plasma from lavender-top (EDTA) tube or frozen plasma from PPT™. Frozen serum from serum separator tube (SST) or frozen serum from red-top tube will not be rejected. Note: Plasma reference ranges will be applied to all specimen types.

Collection Instructions

Separate plasma from cells. Transfer specimen to plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Stability Requirements

Temperature	Period
Room temperature	Unstable
Refrigerated	Unstable
Frozen	14 days

Reference Range

See Plasma Amino Acid Reference Intervals in the Test Resources pages online.

Storage Instructions

Centrifuge, remove plasma from cells, and freeze immediately.

Causes for Rejection

Gross hemolysis; room temperature or thawed specimen; specimens collected in yellow-top (ACD) tubes

LOINC® Map

Order Code	Order Code Name	Order Loinc	Result Code	Result Code Name	UofM	Result LOINC
700068	Amino Acid Profile, Qn, Plasma	35083-5	700007	Taurine	umol/L	20657-3
700068	Amino Acid Profile, Qn, Plasma	35083-5	700008	Aspartate	umol/L	20639-1
700068	Amino Acid Profile, Qn, Plasma	35083-5	700009	Hydroxyproline	umol/L	20647-4
700068	Amino Acid Profile, Qn, Plasma	35083-5	700010	Threonine	umol/L	20658-1
700068	Amino Acid Profile, Qn, Plasma	35083-5	700011	Serine	umol/L	20656-5
700068	Amino Acid Profile, Qn, Plasma	35083-5	700012	Asparagine	umol/L	20638-3
700068	Amino Acid Profile, Qn, Plasma	35083-5	700014	Glutamate	umol/L	20642-5
700068	Amino Acid Profile, Qn, Plasma	35083-5	700015	Glutamine	umol/L	20643-3
700068	Amino Acid Profile, Qn, Plasma	35083-5	700016	Sarcosine	umol/L	26613-0
700068	Amino Acid Profile, Qn, Plasma	35083-5	700017	Alpha-aminoadipate	umol/L	26600-7
700068	Amino Acid Profile, Qn, Plasma	35083-5	700018	Proline	umol/L	20655-7
700068	Amino Acid Profile, Qn, Plasma	35083-5	700019	Glycine	umol/L	20644-1
700068	Amino Acid Profile, Qn, Plasma	35083-5	700020	Alanine	umol/L	20636-7
700068	Amino Acid Profile, Qn, Plasma	35083-5	700022	Citrulline	umol/L	20640-9
700068	Amino Acid Profile, Qn, Plasma	35083-5	700023	Alpha-aminobutyrate	umol/L	20634-2
700068	Amino Acid Profile, Qn, Plasma	35083-5	700024	Valine	umol/L	20661-5
700068	Amino Acid Profile, Qn, Plasma	35083-5	700025	Cystine	umol/L	22672-0
700068	Amino Acid Profile, Qn, Plasma	35083-5	700026	Methionine	umol/L	20651-6
700068	Amino Acid Profile, Qn, Plasma	35083-5	700027	Homocitrulline	umol/L	55876-7
700068	Amino Acid Profile, Qn, Plasma	35083-5	700028	Cystathionine	umol/L	26607-2
700068	Amino Acid Profile, Qn, Plasma	35083-5	700029	Alloisoleucine	umol/L	22670-4
700068	Amino Acid Profile, Qn, Plasma	35083-5	700030	Isoleucine	umol/L	20648-2
700068	Amino Acid Profile, Qn, Plasma	35083-5	700031	Leucine	umol/L	20649-0
700068	Amino Acid Profile, Qn, Plasma	35083-5	700032	Tyrosine	umol/L	20660-7
700068	Amino Acid Profile, Qn, Plasma	35083-5	700033	Phenylalanine	umol/L	14875-9
700068	Amino Acid Profile, Qn, Plasma	35083-5	700034	Argininosuccinate	umol/L	32227-1
700068	Amino Acid Profile, Qn, Plasma	35083-5	700035	Beta-alanine	umol/L	26604-9
700068	Amino Acid Profile, Qn, Plasma	35083-5	700036	Beta-aminoisobutyrate	umol/L	26605-6
700068	Amino Acid Profile, Qn, Plasma	35083-5	700037	Homocystine	umol/L	20646-6
700068	Amino Acid Profile, Qn, Plasma	35083-5	700038	Gamma-aminobutyrate	umol/L	26609-8
700068	Amino Acid Profile, Qn, Plasma	35083-5	700040	Tryptophan	umol/L	20659-9
700068	Amino Acid Profile, Qn, Plasma	35083-5	700041	Hydroxylysine	umol/L	26610-6
700068	Amino Acid Profile, Qn, Plasma	35083-5	700042	Ornithine	umol/L	20652-4
700068	Amino Acid Profile, Qn, Plasma	35083-5	700043	Lysine	umol/L	20650-8
700068	Amino Acid Profile, Qn, Plasma	35083-5	700044	Histidine	umol/L	20645-8
700068	Amino Acid Profile, Qn, Plasma	35083-5	700045	Arginine	umol/L	20637-5
700068	Amino Acid Profile, Qn, Plasma	35083-5	700063	Interpretation		49247-0
700068	Amino Acid Profile, Qn, Plasma	35083-5	700064	Director Review		72486-4
700068	Amino Acid Profile, Qn, Plasma	35083-5	700065	Methodology		49549-9
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700007
Result Code Name	Taurine
UofM	umol/L
Result LOINC	20657-3
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700008
Result Code Name	Aspartate
UofM	umol/L
Result LOINC	20639-1
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700009
Result Code Name	Hydroxyproline
UofM	umol/L
Result LOINC	20647-4
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700010
Result Code Name	Threonine
UofM	umol/L
Result LOINC	20658-1
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700011
Result Code Name	Serine
UofM	umol/L
Result LOINC	20656-5
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700012
Result Code Name	Asparagine
UofM	umol/L
Result LOINC	20638-3
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700014
Result Code Name	Glutamate
UofM	umol/L
Result LOINC	20642-5
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700015
Result Code Name	Glutamine
UofM	umol/L
Result LOINC	20643-3
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700016
Result Code Name	Sarcosine
UofM	umol/L
Result LOINC	26613-0
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700017
Result Code Name	Alpha-aminoadipate
UofM	umol/L
Result LOINC	26600-7
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700018
Result Code Name	Proline
UofM	umol/L
Result LOINC	20655-7
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700019
Result Code Name	Glycine
UofM	umol/L
Result LOINC	20644-1
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700020
Result Code Name	Alanine
UofM	umol/L
Result LOINC	20636-7
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700022
Result Code Name	Citrulline
UofM	umol/L
Result LOINC	20640-9
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700023
Result Code Name	Alpha-aminobutyrate
UofM	umol/L
Result LOINC	20634-2
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700024
Result Code Name	Valine
UofM	umol/L
Result LOINC	20661-5
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700025
Result Code Name	Cystine
UofM	umol/L
Result LOINC	22672-0
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700026
Result Code Name	Methionine
UofM	umol/L
Result LOINC	20651-6
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700027
Result Code Name	Homocitrulline
UofM	umol/L
Result LOINC	55876-7
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700028
Result Code Name	Cystathionine
UofM	umol/L
Result LOINC	26607-2
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700029
Result Code Name	Alloisoleucine
UofM	umol/L
Result LOINC	22670-4
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700030
Result Code Name	Isoleucine
UofM	umol/L
Result LOINC	20648-2
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700031
Result Code Name	Leucine
UofM	umol/L
Result LOINC	20649-0
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700032
Result Code Name	Tyrosine
UofM	umol/L
Result LOINC	20660-7
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700033
Result Code Name	Phenylalanine
UofM	umol/L
Result LOINC	14875-9
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700034
Result Code Name	Argininosuccinate
UofM	umol/L
Result LOINC	32227-1
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700035
Result Code Name	Beta-alanine
UofM	umol/L
Result LOINC	26604-9
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700036
Result Code Name	Beta-aminoisobutyrate
UofM	umol/L
Result LOINC	26605-6
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700037
Result Code Name	Homocystine
UofM	umol/L
Result LOINC	20646-6
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700038
Result Code Name	Gamma-aminobutyrate
UofM	umol/L
Result LOINC	26609-8
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700040
Result Code Name	Tryptophan
UofM	umol/L
Result LOINC	20659-9
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700041
Result Code Name	Hydroxylysine
UofM	umol/L
Result LOINC	26610-6
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700042
Result Code Name	Ornithine
UofM	umol/L
Result LOINC	20652-4
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700043
Result Code Name	Lysine
UofM	umol/L
Result LOINC	20650-8
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700044
Result Code Name	Histidine
UofM	umol/L
Result LOINC	20645-8
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700045
Result Code Name	Arginine
UofM	umol/L
Result LOINC	20637-5
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700063
Result Code Name	Interpretation
UofM
Result LOINC	49247-0
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700064
Result Code Name	Director Review
UofM
Result LOINC	72486-4
Order Code	700068
Order Code Name	Amino Acid Profile, Qn, Plasma
Order Loinc	35083-5
Result Code	700065
Result Code Name	Methodology
UofM
Result LOINC	49549-9

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