WC12 2023 -- Cardiovascular disease is the leading cause of death worldwide; however, no regulatory assays are currently available to predict drug/chemical-linked effects on atherosclerosis (an inflammatory process involving a series of progressive cellular events, including monocyte adhesion to the luminal endothelial surface).

Pulmonary fibrosis is a progressive interstitial lung disease characterized by increased deposition of extra cellular matrix and scarring of lung tissue over an extended period of time.

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by increased deposition of extra cellular matrix and scarring of lung tissue over an extended period of time. The deposition of extra cellular matrix and scarring leads to a decline in lung function which is ultimately fatal.

Short term cigarette smoke (CS) exposure in mice has been shown to induce changes exhibiting similarities to cell and cell-mediated inflammation observed in patients with COPD. Evaluate the efficacy of an inhaled PDE4 inhibitor, GSK256066, in a murine 4-day acute cigarette smoke model.

Pulmonary fibrosis is an interstitial lung disease characterised by scarring of the lung tissue leading to a decline in lung function which eventually becomes fatal. There are currently very limited treatment options and even with treatment the life expectancy after diagnosis is only three to five years.

The most objective indicator of asthma severity in the clinic is the measurement of reversible airway obstruction by spirometry. This poster demonstrates that allergen (ovalbumin) challenge results in a reversible decline in measured FEV100, PEF, and FVC in a rat allergic model.

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by increased deposition of extra cellular matrix and scarring of lung tissue over an extended period. There are currently only two approved treatments for pulmonary fibrosis, both of which slow down the decline in lung function in some patient cohorts.

House dust mite (HDM) allergens are associated with allergic disorders and the use of this clinically relevant antigen is increasing in preclinical animal models. We assessed the chronic inflammatory time course and the anti-inflammatory efficacy of a phosphodiesterase 4 (PDE4) inhibitor and a corticosteroid in a five week HDM model.

Influenza virus infection in humans results in a respiratory disease that ranges in severity from sub-clinical infection to primary viral pneumonia. 40-60% of acute exacerbations in COPD are associated with respiratory virus infection; 85% of asthma attacks in children and 44% in adults are precipitated by upper respiratory tract infection.

ECVP 2023 -- The Extended One-Generation Reproductive Toxicity Study (OECD 2018, Test No. 443) tests for effects of pre- and post-natal chemical exposure. Dosing covers mating, fertility, pregnancy, lactation and development of offspring up to 13 weeks of age.