Drug resistance testing
Drug resistance testing provides HIV-1 antiretroviral susceptibility data to assist clinicians in the selection of the most effective treatment regimen for each patient.
HIV clinical testing
PrEP screening
At Labcorp, we offer the latest CDC-compliant PrEP baseline and monitoring panels for oral and injectable PrEP, helping you minimize unnecessary out-of-pocket costs so you can focus on what matters most: your patients.
?fmt=webp)
Screening and diagnosis
The Centers for Disease Control (CDC) recommends HIV testing for all individuals between ages 13 and 64 at least once as part of standard health care.
?fmt=webp)
HIV test codes
| Assay Type | Test Name | Labcorp Test Number | Clinical Use | Test code for Monogram direct clients |
|---|---|---|---|---|
| Viral Load | HIV-1 Quantitative, Real-Time PCR (Roche COBAS® TaqMan® 2.0) | Graphical: 550420 Non-graphical: 550430 | Quantitative measurement of HIV-1 RNA in plasma. Can be used to assess disease progression and to monitor the efficacy of antiretroviral therapy. | V1000 |
| Genotypic Resistance Testing | GenoSure PRIme® | 551700 | Detects resistance in HIV-1 to antiretroviral drugs (NRTIs, NNRTIs, PIs, and INIs). | P5000 |
| Genotypic Resistance Testing | GenoSure® MG | 551697 | Detects resistance in HIV-1 to antiretroviral drugs (NRTIs, NNRTIs, and PIs). | G5000 |
| Phenotypic and Genotypic Resistance Testing | PhenoSense GT® | 551690 | Determines viral phenotype and genotype resistance to antiretroviral drugs (NRTIs, NNRTIs, and PIs). Viral replication capacity is included. | V7000 |
| Phenotypic and Genotypic Resistance Testing | PhenoSense GT®Plus Integrase | 551920 | Determines viral phenotype and genotype resistance to antiretroviral drugs (NRTIs, NNRTIs, PIs, and INIs). | M7000 |
| Phenotypic Resistance Testing | PhenoSense® | 551800 | Determines viral phenotype resistance to antiretroviral drugs (NRTIs, NNRTIs, and PIs). Viral replication capacity is included. | V3200 |
| Phenotypic Resistance Testing | PhenoSense® Integrase | 550230 | Determines viral phenotype resistance to integrase inhibitors. Viral replication capacity is included. | S3200 |
| Phenotypic Resistance Testing | PhenoSense® Entry | 550240 | Determines viral phenotype resistance to enfuvirtide. | E2000 |
| Suppression Management | GenoSure Archive® | 551776 | In patients with suppressed or low level virus (less than 500 copies/mL), detects resistance in HIV-1 to antiretroviral drugs (NRTIs, NNRTIs, PIs, and INIs). | R6000 |
| Suppression Management Super Panel | GenoSure Archive® and Trofile® DNA | 552020 | In patients with suppressed or low level virus (less than 500 copies/mL), detects resistance in HIV-1 to antiretroviral drugs (NRTIs, NNRTIs, PIs, and INIs) and provides coreceptor tropism status. | R6000S/E3600S |
| Coreceptor Tropism Testing | Trofile® | 553100 | Detect HIV-1 coreceptor tropism to determine patient eligibility for treatment with a CCR5 antagonist. | E3100 |
| Coreceptor Tropism Testing | Trofile® DNA | 829670 | Detect HIV-1 coreceptor tropism to determine patient eligibility for a CCR5 antagonist. | E3600 |
| Coreceptor Tropism Testing | Trofile® Select | 553355 | Determines HIV-1 coreceptor tropism status by selection of the appropriate assay, Trofile or Trofile DNA, through an initial prescreening viral assessment. | MGB E3000 |
Viral Load Reflex Testing
Viral load reflex testing offers the ability for the laboratory to perform an HIV-1 viral load to establish the patient viral load at the time of resistance testing. This ensures there will be adequate virus to amplify for resistance testing. If the viral load meets viral load requirements for the preferred assay, testing will proceed. If there is insufficient viral load, the viral load results will be reported and testing will be stopped.
Labcorp offers several options for viral load reflex testing.
| HIV-1 Viral load reflex to: | Graphical | Nongraphical |
|---|---|---|
| GeoSure Archive®or GenoSure PRIme® | 550920 | 550675 |
| GenoSure PRIme® | 550630 | 550655 |
| GenoSure® MG | 550422 | 550432 |
| PhenoSense GT® | 550510 | 550450 |
| PhenoSense GT®Plus Integrase | 550711 | 550625 |
| PhenoSense® | 550520 | 550470 |
| PhenoSense Integrase® | 550250 | 550280 |
| PhenoSense Entry® | 550330 | 550360 |
| Trofile® | 550390 | 550310 |