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TESTING FOR CHRONIC URTICARIA

Diagnosing autoimmune chronic urticaria

Chronic urticaria is a disorder where hives occur without an identifiable provoking factor and can last for more than six weeks, greatly impacting a patient’s quality of life.¹⁻² Knowing if the cause is autoimmune is critical since some patients may not respond to antihistamines and other medications.
Chronic urticaria is a disorder where hives occur without an identifiable provoking factor and can last for more than six weeks, greatly impacting a patient’s quality of life.1,2 Knowing if the cause is autoimmune is critical since some patients may not respond to antihistamines and other medications.

Comprehensive testing solutions for chronic urticaria

Diagnosing autoimmune chronic urticaria involves clinical evaluation, diagnostic criteria and various testing methods. Labcorp’s proprietary testing for chronic urticaria, a pooled donor basophil activation test (PD-BAT), provides reliable and consistent patient evaluations and does not interfere with antihistamines and corticosteroids.3

Chronic Urticaria - Pooled Donor Basophil Activation Testing (PD-BAT)

Includes Labcorp’s novel Chronic Urticaria PD-BAT

 

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Chronic Urticaria Evaluation Profile

Includes Labcorp’s novel Chronic Urticaria PD-BAT and other tests for the definition, classification, diagnosis and management of urticaria1 
 

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Explore our broad portfolio of allergy testing to rule in or rule out other potential causes of a patient’s hives

 

Improve therapeutic management of chronic urticaria patients with Labcorp’s basophil activation testing

Proprietary methodology for optimizing PD-BAT assay performance for more consistent patient evaluations³

There is great variability in the activation potential of individual donors. By pooling a number of responsive donors, the assay produces a consistent response from run to run.

Increased accuracy and precision over standard basophil activation testing³

The assay measures basophil activation, not basophil histamine response. Basophil activation is considered more sensitive and accurate due to its ability to detect lower levels of basophil activation.3,4

No interferences from antihistamines or corticosteroids³

Unlike conventional chronic urticaria testing, Labcorp's PD-BAT allows patients (often seeking symptom relief) to stay on their medication.

 

Still have questions? Explore these additional resources

 

References

1. Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA² LEN/EuroGuiDerm /APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022 Mar;77(3):734-766.

2. Chronic Idiopathic Urticaria-CIU. Allergy & Asthma Network. Accessed January 10, 2025. https://allergyasthmanetwork.org/chronic-urticaria/ciu/

3. Wills S, Chavez J, Grover A, et al. PD-BAT: A novel approach of pooling basophil donors for expansion of commercial laboratory testing of Chronic Spontaneous Urticaria. J Immunol Methods. 2024 Jun;529:113679.

4. Santos A,  Alpan O,  Hans-Jürgen. Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice. Allergy. 2021;76:2420–2432.