Test Details
Methodology
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Result Turnaround Time
2 - 4 days
Use
Monitor immunosuppressive therapy following organ transplant
Specimen Requirements
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
References
Custom Additional Information
Sirolimus may be administered in conjunction with cyclosporine (CsA) and corticosteroids to reduce or prevent host graft rejection. Using this therapy, peak concentrations are achieved in one to two hours. The mean terminal elimination half-life is 62 hours.1 Drug-drug interactions, including CsA, may alter the pharmacokinetics of sirolimus, making therapeutic drug monitoring appropriate.
Specimen
Whole blood
Volume
3 mL
Minimum Volume
1.1 mL
Container
Lavender-top (EDTA) tube
Storage Instructions
Room temperature
Causes for Rejection
Clotted specimen
Collection Instructions
Trough: 30 minutes to one hour before the next oral dose
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Reference Range
3.0−20.0 ng/mL