Test Details
Methodology
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Result Turnaround Time
4 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Treatment of susceptible fungal infections in immunocompromised and immunocompetent patients including blastomycosis and histoplasmosis; indicated for aspergillosis and onychomycosis of the toenail and fingernail. It has been recommended that routine monitoring occur during the first week of therapy to ensure therapeutic levels are achieved for each individual and to continue monitoring if clinical presentations do not improve or decline.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
Specimen Requirements
Specimen
Serum (preferred) or plasma
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or lavender-top (EDTA) tube
Collection Instructions
Transfer separated serum or plasma to a plastic transport tube. Do not use a gel barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage times, the decrease in drug level due to absorption may be clinically significant.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Storage Instructions
Refrigerate. Stable for 14 days at room temperature, refrigerated, or frozen.
Causes for Rejection
Gel barrier tubes
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 700833 | Itraconazole and Mtb, S/P | 700283 | Itraconazole | ug/mL | 10989-2 | |
| 700833 | Itraconazole and Mtb, S/P | 700835 | Hydroxyitraconazole | ug/mL | 18337-6 | |
| Order Code | 700833 | |||||
| Order Code Name | Itraconazole and Mtb, S/P | |||||
| Order Loinc | ||||||
| Result Code | 700283 | |||||
| Result Code Name | Itraconazole | |||||
| UofM | ug/mL | |||||
| Result LOINC | 10989-2 | |||||
| Order Code | 700833 | |||||
| Order Code Name | Itraconazole and Mtb, S/P | |||||
| Order Loinc | ||||||
| Result Code | 700835 | |||||
| Result Code Name | Hydroxyitraconazole | |||||
| UofM | ug/mL | |||||
| Result LOINC | 18337-6 |