Voriconazole, Serum or Plasma

TEST: 700353
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CPT: 80285
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Synonyms

  • UK-109,496
  • Vfend®

Expected Turnaround Time

3 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Serum (preferred) or plasma

Volume

1 mL

Minimum Volume

0.5 mL

Container

Red-top tube or lavender-top (EDTA) tube

Collection

Transfer separated serum or plasma to a plastic transport tube. Do not use a gel barrier tube. The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage times, the decrease in drug level due to absorption may be clinically significant.

Storage Instructions

Refrigerate. Stable for 14 days at room temperature, refrigerated, or frozen.

Causes for Rejection

Gel-barrier tube

Test Details

Use

Treatment of invasive aspergillosis; treatment of esophageal candidiasis; treatment of candidemia; treatment of candida deep tissue infections; treatment of serious fungal infections caused by Scedosporium apiospermum and fusarium spp in patients intolerant or refractory to other therapy.

Limitations

This test was developed, and its performance characteristics determined, by LabCorp. It has not been cleared or approved by the US Food and Drug Administration (FDA). The FDA has determined that such clearance or approval is not necessary.

Methodology

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)

References

Andes D, Pascual A, Marchetti O. Antifungal therapeutic drug monitoring: Established and emerging indications. Antimicrob Agents Chemother.
Clinical Primer: Potential Hepatic Complications With Triazole Therapy. Tinton Falls, NJ: Fallon Medica LLC; 2010.
Drug Information Handbook. 24th ed. Hudson, OH: Wolters Kluwer Clinical Drug Information, Inc; 2015; 2176-2182.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
700353 Voriconazole, Serum/Plasma 38370-3 700354 Voriconazole, Serum/Plasma ug/mL 38370-3

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