Test Details
Methodology
SNaPshot Multiplex PCR (primer extension-based method)
Result Turnaround Time
5 - 7 days
Use
KRAS is a guanosine triphosphate (GTP) binding protein involved in downstream receptor signaling, which is critical for cell proliferation, survival and differentiation. Mutations in the KRAS oncogene are frequently found in human cancers. They are common in pancreatic, colorectal, lung, gallbladder, bile duct and thyroid cancer. This assay will detect KRAS mutations in exons 2, 3 and 4, allowing the determination of drug response.
Special Instructions
Provide a copy of the pathology report; the KRAS test will be delayed if the pathology report is not received. Direct any questions regarding this test to customer service at 800-345-4363.
Specimen Requirements
Limitations
This assay is able to detect 5% mutation in a background of wild-type DNA.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
References
Specimen
Formalin-fixed, paraffin-embedded (FFPE) tissue block or slides
Volume
Formalin-fixed, paraffin-embedded tissue block or four unstained slides and one matching H&E-stained slide at 5 µM
Minimum Volume
Two unstained slides and one matching H&E-stained slide at 5 μM (samples with >4 mm² and ≥50% tumor content are preferred)
Container
FFPE tissue blocks or slides
Storage Instructions
Maintain blocks and slides at room temperature.
Causes for Rejection
Tumor block containing no tumor tissue; broken or stained slides
LOINC® Map
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
570203 | KRAS Mutation Analysis | 570204 | Referring Physician | 18781-5 | ||
570203 | KRAS Mutation Analysis | 570205 | Treating Physician | 18781-5 | ||
570203 | KRAS Mutation Analysis | 570206 | Body Site | 39111-0 | ||
570203 | KRAS Mutation Analysis | 570207 | Client Specimen ID | N/A | ||
570203 | KRAS Mutation Analysis | 570208 | Specimen(s) Received | 31208-2 | ||
570203 | KRAS Mutation Analysis | 570209 | Clinical Data | 55752-0 | ||
570203 | KRAS Mutation Analysis | 570210 | Results: | 50397-9 | ||
570203 | KRAS Mutation Analysis | 570211 | Interpretation | 62365-2 | ||
570203 | KRAS Mutation Analysis | 570212 | Analytical Results | 21702-6 | ||
570203 | KRAS Mutation Analysis | 570213 | Comments | 77202-0 | ||
570203 | KRAS Mutation Analysis | 570214 | Methodology: | 49549-9 | ||
570203 | KRAS Mutation Analysis | 570215 | References: | 75608-0 | ||
570203 | KRAS Mutation Analysis | 570216 | Electronically Signed by | 19131-5 | ||
570203 | KRAS Mutation Analysis | 570217 | Disclaimer | N/A | ||
570203 | KRAS Mutation Analysis | 570218 | 11502-2 | |||
570203 | KRAS Mutation Analysis | 570219 | Bill Code Entry Hold | N/A | ||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570204 | |||||
Result Code Name | Referring Physician | |||||
UofM | ||||||
Result LOINC | 18781-5 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570205 | |||||
Result Code Name | Treating Physician | |||||
UofM | ||||||
Result LOINC | 18781-5 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570206 | |||||
Result Code Name | Body Site | |||||
UofM | ||||||
Result LOINC | 39111-0 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570207 | |||||
Result Code Name | Client Specimen ID | |||||
UofM | ||||||
Result LOINC | N/A | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570208 | |||||
Result Code Name | Specimen(s) Received | |||||
UofM | ||||||
Result LOINC | 31208-2 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570209 | |||||
Result Code Name | Clinical Data | |||||
UofM | ||||||
Result LOINC | 55752-0 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570210 | |||||
Result Code Name | Results: | |||||
UofM | ||||||
Result LOINC | 50397-9 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570211 | |||||
Result Code Name | Interpretation | |||||
UofM | ||||||
Result LOINC | 62365-2 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570212 | |||||
Result Code Name | Analytical Results | |||||
UofM | ||||||
Result LOINC | 21702-6 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570213 | |||||
Result Code Name | Comments | |||||
UofM | ||||||
Result LOINC | 77202-0 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570214 | |||||
Result Code Name | Methodology: | |||||
UofM | ||||||
Result LOINC | 49549-9 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570215 | |||||
Result Code Name | References: | |||||
UofM | ||||||
Result LOINC | 75608-0 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570216 | |||||
Result Code Name | Electronically Signed by | |||||
UofM | ||||||
Result LOINC | 19131-5 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570217 | |||||
Result Code Name | Disclaimer | |||||
UofM | ||||||
Result LOINC | N/A | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570218 | |||||
Result Code Name | ||||||
UofM | ||||||
Result LOINC | 11502-2 | |||||
Order Code | 570203 | |||||
Order Code Name | KRAS Mutation Analysis | |||||
Order Loinc | ||||||
Result Code | 570219 | |||||
Result Code Name | Bill Code Entry Hold | |||||
UofM | ||||||
Result LOINC | N/A |
Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
---|---|---|---|---|---|---|
Reflex 1 | 057203 | KRAS Mutation Analysis (B) | 000000 | Results | Pending | |
Reflex 1 | ||||||
Order Code | 057203 | |||||
Order Name | KRAS Mutation Analysis (B) | |||||
Result Code | 000000 | |||||
Result Name | Results | |||||
UofM | ||||||
Result LOINC | Pending |
Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
---|---|---|---|---|---|---|
Reflex 1 | 057203 | KRAS Mutation Analysis (B) | 000000 | Results | Pending | |
Reflex 1 | ||||||
Order Code | 057203 | |||||
Order Name | KRAS Mutation Analysis (B) | |||||
Result Code | 000000 | |||||
Result Name | Results | |||||
UofM | ||||||
Result LOINC | Pending |
Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
---|---|---|---|---|---|---|
Reflex 1 | 057203 | KRAS Mutation Analysis (B) | 000000 | Results | Pending | |
Reflex 1 | ||||||
Order Code | 057203 | |||||
Order Name | KRAS Mutation Analysis (B) | |||||
Result Code | 000000 | |||||
Result Name | Results | |||||
UofM | ||||||
Result LOINC | Pending |
Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
---|---|---|---|---|---|---|
Reflex 1 | 057203 | KRAS Mutation Analysis (B) | 000000 | Results | Pending | |
Reflex 1 | ||||||
Order Code | 057203 | |||||
Order Name | KRAS Mutation Analysis (B) | |||||
Result Code | 000000 | |||||
Result Name | Results | |||||
UofM | ||||||
Result LOINC | Pending |
Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
---|---|---|---|---|---|---|
Reflex 1 | 057203 | KRAS Mutation Analysis (B) | 000000 | Results | Pending | |
Reflex 1 | ||||||
Order Code | 057203 | |||||
Order Name | KRAS Mutation Analysis (B) | |||||
Result Code | 000000 | |||||
Result Name | Results | |||||
UofM | ||||||
Result LOINC | Pending |
Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
---|---|---|---|---|---|---|
Reflex 1 | 057203 | KRAS Mutation Analysis (B) | 000000 | 11526-1 | ||
Reflex 1 | ||||||
Order Code | 057203 | |||||
Order Name | KRAS Mutation Analysis (B) | |||||
Result Code | 000000 | |||||
Result Name | ||||||
UofM | ||||||
Result LOINC | 11526-1 |