Test Details
Methodology
See individual test components.
Result Turnaround Time
14 - 21 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
Anti-DFS70; Anti-Sm; Anti-U1 RNP; Anti-Ro (SS-A); Anti-La (SS-B); Anti-Scl-70; Anti-Jo-1
Use
Anti-ENA6 Plus DFS70 is designed to facilitate the proper triage of patients with positive Anti-Nuclear Antibodies (ANA) by identifying those most likely to benefit from a rheumatology specialist. It detects the novel Anti-DFS70 along with 6 other clinically useful autoantibodies to ENA, which may help identify systemic lupus erythematous (SLE), mixed connective tissue disease (MCTD), Sjogren's, systemic sclerosis, and idiopathic inflammatory myopathy (IIM). Positive Anti-DFS70 antibodies in isolation may help identify individuals who do not have an AARD (ANA-associated rheumatic disease), especially in the absence of significant clinical findings.
Anti-DFS70 Abs confer a likelihood ratio for the absence of systemic autoimmune rheumatic disease of 10.9 and are detectable in 2% to 22% of healthy individuals and in less than 1% of patients with AARD.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
References
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Stability Requirements
Temperature | Period |
---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x1 |
Storage Instructions
Refrigerate.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic, icteric, non-serum specimen types
LOINC® Map
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
520301 | Anti-ENA6 Plus DFS70Ab Profile | 520316 | Anti-DFS70 Ab | Units | 95129-3 | |
520301 | Anti-ENA6 Plus DFS70Ab Profile | 520216 | Anti-Sm Ab (RDL) | Units | 11090-8 | |
520301 | Anti-ENA6 Plus DFS70Ab Profile | 520217 | Anti-U1 RNP Ab (RDL) | Units | 57662-9 | |
520301 | Anti-ENA6 Plus DFS70Ab Profile | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 | |
520301 | Anti-ENA6 Plus DFS70Ab Profile | 520225 | Anti-La (SS-B) Ab (RDL) | Units | 45142-7 | |
520301 | Anti-ENA6 Plus DFS70Ab Profile | 520221 | Anti-Scl-70 Ab (RDL) | Units | 26975-3 | |
520301 | Anti-ENA6 Plus DFS70Ab Profile | 520259 | Anti-Jo-1 Ab (RDL) | Units | 35333-4 | |
Order Code | 520301 | |||||
Order Code Name | Anti-ENA6 Plus DFS70Ab Profile | |||||
Order Loinc | ||||||
Result Code | 520316 | |||||
Result Code Name | Anti-DFS70 Ab | |||||
UofM | Units | |||||
Result LOINC | 95129-3 | |||||
Order Code | 520301 | |||||
Order Code Name | Anti-ENA6 Plus DFS70Ab Profile | |||||
Order Loinc | ||||||
Result Code | 520216 | |||||
Result Code Name | Anti-Sm Ab (RDL) | |||||
UofM | Units | |||||
Result LOINC | 11090-8 | |||||
Order Code | 520301 | |||||
Order Code Name | Anti-ENA6 Plus DFS70Ab Profile | |||||
Order Loinc | ||||||
Result Code | 520217 | |||||
Result Code Name | Anti-U1 RNP Ab (RDL) | |||||
UofM | Units | |||||
Result LOINC | 57662-9 | |||||
Order Code | 520301 | |||||
Order Code Name | Anti-ENA6 Plus DFS70Ab Profile | |||||
Order Loinc | ||||||
Result Code | 520218 | |||||
Result Code Name | Anti-Ro (SS-A) Ab (RDL) | |||||
UofM | Units | |||||
Result LOINC | 33569-5 | |||||
Order Code | 520301 | |||||
Order Code Name | Anti-ENA6 Plus DFS70Ab Profile | |||||
Order Loinc | ||||||
Result Code | 520225 | |||||
Result Code Name | Anti-La (SS-B) Ab (RDL) | |||||
UofM | Units | |||||
Result LOINC | 45142-7 | |||||
Order Code | 520301 | |||||
Order Code Name | Anti-ENA6 Plus DFS70Ab Profile | |||||
Order Loinc | ||||||
Result Code | 520221 | |||||
Result Code Name | Anti-Scl-70 Ab (RDL) | |||||
UofM | Units | |||||
Result LOINC | 26975-3 | |||||
Order Code | 520301 | |||||
Order Code Name | Anti-ENA6 Plus DFS70Ab Profile | |||||
Order Loinc | ||||||
Result Code | 520259 | |||||
Result Code Name | Anti-Jo-1 Ab (RDL) | |||||
UofM | Units | |||||
Result LOINC | 35333-4 |
Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
---|---|---|---|---|---|---|
Reflex 1 | 520341 | Repeat Anti-Scl-70 | 520341 | Repeat Anti-Scl-70 | 5348-8 | |
Reflex 1 | ||||||
Order Code | 520341 | |||||
Order Name | Repeat Anti-Scl-70 | |||||
Result Code | 520341 | |||||
Result Name | Repeat Anti-Scl-70 | |||||
UofM | ||||||
Result LOINC | 5348-8 |