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ANA 12 Profile, Do All (RDL)

Test Number 520299
Test number copied
CPT

86038; 86147(x3); 86160(x2); 86225; 86235(x6); 86376
Synonyms
  • ANA 12
  • ANA 12 Panel
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  • Updated on 02/13/2025

Test Details

Methodology

See individual test components.

Result Turnaround Time

14 - 21 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Antinuclear Antibodies Testing Options in Rheumatology Brochure

Autoimmune Profiles Brochure

Lupus Comprehensive Testing Brochure

Test Includes

This profile is comprised of Anti‐Nuclear Ab (ANA) by IFA, Anti‐dsDNA Ab by Farr, Anti‐ENA Abs (Anti‐Sm & Anti‐RNP), Anti‐Centromere Ab, C3 & C4 Complements, Anti‐Ro (SS‐A) Ab, Anti‐La (SS‐B) Ab, Anti‐Scl‐70 Ab, Anti‐cardiolipin Abs (IgG, IgA & IgM isotypes) and Anti‐TPO (Thyroid Microsomal Peroxidase) Ab.

This profile is comprised of Anti‐Nuclear Ab (ANA) by IFA, Anti‐dsDNA Ab by Farr, Anti‐ENA Abs (Anti‐Sm & Anti‐RNP), Anti‐Centromere Ab, C3 & C4 Complements, Anti‐Ro (SS‐A) Ab, Anti‐La (SS‐B) Ab, Anti‐Scl‐70 Ab, Anti‐cardiolipin Abs (IgG, IgA & IgM isotypes), Anti‐TPO (Thyroid Microsomal Peroxidase) Ab, Anti‐Chromatin Ab.

This profile is comprised of Anti‐Nuclear Ab (ANA) by IFA, Anti‐dsDNA Ab by Farr, Anti‐ENA Abs (Anti‐Sm & Anti‐RNP), Anti‐Centromere Ab, C3 & C4 Complements, Anti‐Ro (SS‐A) Ab, Anti‐La (SS‐B) Ab, Anti‐Scl‐70 Ab, Anti‐cardiolipin Abs (IgG, IgA & IgM isotypes) and Anti‐TPO (Thyroid Microsomal Peroxidase) Ab.

Use

The ANA test detects autoantibodies that bind to the nuclear components of HEp-2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic and potential prognostic utility for several autoimmune diseases.

RDL’s ANA 12 Profile Helps Differentiate Between 8 Autoimmune Disease States:

SLE

• ANA by IFA

Tests with high specificity

• Anti-dsDNA by Farr

• Anti-SM

Tests with moderate specificity

• Anti-Ro

• Anti-La

• C3 & C4 Complements

• Anticardiolipin IgG, IgA & IgM

Sjogren’s Syndrome

• Anti-Ro

• Anti-La

Mixed Connective Tissue Disease (MCTD)

• Anti-U1 RNP

Limited Scleroderma (CREST)

• Anti-Centromere

Diffuse Scleroderma

• Anti-SCL-70 by EIA, confirmed by ID

Autoimmune Thyroid Disease

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Serum

Volume

4 mL

Minimum Volume

1.5 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection Instructions

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Stability Requirements

TemperaturePeriod
Room temperature7 days
Refrigerated14 days
Frozen60 days
Freeze/thaw cyclesStable x1

Storage Instructions

Refrigerate or freeze.

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520299 ANA 12 Profile, Do All RDL 97564-9 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
520299 ANA 12 Profile, Do All RDL 97564-9 520066 Anti-Centromere Ab by IFA(RDL) 5077-3
520299 ANA 12 Profile, Do All RDL 97564-9 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
520299 ANA 12 Profile, Do All RDL 97564-9 520216 Anti-Sm Ab (RDL) Units 11090-8
520299 ANA 12 Profile, Do All RDL 97564-9 520217 Anti-U1 RNP Ab (RDL) Units 57662-9
520299 ANA 12 Profile, Do All RDL 97564-9 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
520299 ANA 12 Profile, Do All RDL 97564-9 520225 Anti-La (SS-B) Ab (RDL) Units 45142-7
520299 ANA 12 Profile, Do All RDL 97564-9 520221 Anti-Scl-70 Ab (RDL) Units 26975-3
520299 ANA 12 Profile, Do All RDL 97564-9 520223 Anti-Cardiolipin Ab, IgG (RDL) GPL U/mL 3181-5
520299 ANA 12 Profile, Do All RDL 97564-9 520182 Anti-Cardiolipin Ab, IgA (RDL) APL U/mL 5076-5
520299 ANA 12 Profile, Do All RDL 97564-9 520183 Anti-Cardiolipin Ab, IgM (RDL) MPL U/mL 3182-3
520299 ANA 12 Profile, Do All RDL 97564-9 520169 C3 Complement (RDL) mg/dL 4485-9
520299 ANA 12 Profile, Do All RDL 97564-9 520167 C4 Complement (RDL) mg/dL 4498-2
520299 ANA 12 Profile, Do All RDL 97564-9 520036 Anti-TPO Ab (RDL) IU/mL 8099-4
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520073
Result Code NameAnti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC42254-3
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520066
Result Code NameAnti-Centromere Ab by IFA(RDL)
UofM
Result LOINC5077-3
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520060
Result Code NameAnti-dsDNA Ab by Farr(RDL)
UofMIU/mL
Result LOINC47299-3
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520216
Result Code NameAnti-Sm Ab (RDL)
UofMUnits
Result LOINC11090-8
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520217
Result Code NameAnti-U1 RNP Ab (RDL)
UofMUnits
Result LOINC57662-9
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520218
Result Code NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520225
Result Code NameAnti-La (SS-B) Ab (RDL)
UofMUnits
Result LOINC45142-7
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520221
Result Code NameAnti-Scl-70 Ab (RDL)
UofMUnits
Result LOINC26975-3
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520223
Result Code NameAnti-Cardiolipin Ab, IgG (RDL)
UofMGPL U/mL
Result LOINC3181-5
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520182
Result Code NameAnti-Cardiolipin Ab, IgA (RDL)
UofMAPL U/mL
Result LOINC5076-5
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520183
Result Code NameAnti-Cardiolipin Ab, IgM (RDL)
UofMMPL U/mL
Result LOINC3182-3
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520169
Result Code NameC3 Complement (RDL)
UofMmg/dL
Result LOINC4485-9
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520167
Result Code NameC4 Complement (RDL)
UofMmg/dL
Result LOINC4498-2
Order Code520299
Order Code NameANA 12 Profile, Do All RDL
Order Loinc97564-9
Result Code520036
Result Code NameAnti-TPO Ab (RDL)
UofMIU/mL
Result LOINC8099-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520074 Homogeneous Pattern 20398-4
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520074
Result NameHomogeneous Pattern
UofM
Result LOINC20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520076 Nucleolar Pattern 20399-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520076
Result NameNucleolar Pattern
UofM
Result LOINC20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520233 Speckled Pattern 20401-6
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520233
Result NameSpeckled Pattern
UofM
Result LOINC20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520234 Centromere Pattern 53993-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520234
Result NameCentromere Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520235 Spindle Apparatus Pattern 53003-0
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520235
Result NameSpindle Apparatus Pattern
UofM
Result LOINC53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520236 Nuclear Membrane Pattern 54006-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520236
Result NameNuclear Membrane Pattern
UofM
Result LOINC54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520237 Midbody Pattern 54155-7
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520237
Result NameMidbody Pattern
UofM
Result LOINC54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520238 Nuclear Dot Pattern 53998-1
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520238
Result NameNuclear Dot Pattern
UofM
Result LOINC53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520239 PCNA Pattern 53006-3
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520239
Result NamePCNA Pattern
UofM
Result LOINC53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520240 Centriole Pattern 53993-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520240
Result NameCentriole Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520241 Note: 77202-0
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520241
Result NameNote:
UofM
Result LOINC77202-0
Reflex Table for Anti-Scl-70 Ab (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520341 Repeat Anti-Scl-70 520341 Repeat Anti-Scl-70 5348-8
Reflex 1
Order Code520341
Order NameRepeat Anti-Scl-70
Result Code520341
Result NameRepeat Anti-Scl-70
UofM
Result LOINC5348-8