Skip to main content

Glomerulonephritis (GNP) Profile (RDL)

CPT 83516(x3); 83520; 86036; 86160(x2); 86225

Test Details

Methodology

See individual test components.

Result Turnaround Time

10 - 12 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Autoimmune Profiles Brochure

Test Includes

This profile is composed of Anti-Nuclear Ab (ANA) by IFA, Anti-dsDNA Ab by Farr, Anti-Glomerular Basement Membrane Ab (GBM), Anti-Neutrophil Cytoplasmic Ab (ANCA), Anti-Myeloperoxidase Ab (MPO), Anti-Proteinase 3 Ab (PR-3), C3 Complement, C4 Complement.

ANA performed if ANCA positive to rule out false positive ANCA due to presence of ANA.

Use

ANA are commonly present in a variety of autoimmune diseases. ANA frequency also increases with age in apparently healthy people. ANA patterns on HEp-2 slides provide general clues about particles (chromatin, nucleosomes, and spliceosomes).

The Farr assay is the most specific method for detecting dsDNA autoantibodies. Significant elevations in dsDNA autoantibody concentrations confirm the diagnosis of systemic lupus erythematosus (SLE). Serial studies of elevated values of dsDNA auto antibodies are useful for predicting activity of SLE.

Anti-MPO autoantibodies aid in assessment of certain autoimmune vasculitides such as microscopic polyarteritis, and crescentic glomerulonephritis.

Elevated levels of Anti-PR-3 antibodies are classically observed in patients with Wegener granulomatosis (WG), particularly with active disease, and less frequently in other forms of necrotizing vasculitis.

Anti-GBM autoantibodies are recognized as being important in the pathogenesis of the rapidly progressive glomerulonephritis of Goodpasture's syndrome. Measurements of C3 and C4 are used to detect individuals with inborn deficiency of this factor or those with immunologic disease in whom complement is consumed at an increased rate. These include lupus erythematosus, chronic active hepatitis, certain chronic infections, post-streptococcal and membranoproliferative glomerulonephritis, and others.

Specimen Requirements

Specimen

Serum

Volume

4 mL

Minimum Volume

1.5 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection Instructions

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Stability Requirements

Temperature

Period

Room temperature

2 days

Refrigerated

8 days

Frozen

8 days

Storage Instructions

Refrigerate or freeze.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520194 Glomerulonephritis (GNP) Prof 97564-9 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
520194 Glomerulonephritis (GNP) Prof 97564-9 520150 ANCA by IFA (RDL) 29641-8
520194 Glomerulonephritis (GNP) Prof 97564-9 520211 Anti-MPO Ab (RDL) Units 46266-3
520194 Glomerulonephritis (GNP) Prof 97564-9 520215 Anti-PR-3 Ab (RDL) Units 46267-1
520194 Glomerulonephritis (GNP) Prof 97564-9 520249 Anti-GBM Ab (RDL) Units 31406-2
520194 Glomerulonephritis (GNP) Prof 97564-9 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
520194 Glomerulonephritis (GNP) Prof 97564-9 520169 C3 Complement (RDL) mg/dL 4485-9
520194 Glomerulonephritis (GNP) Prof 97564-9 520167 C4 Complement (RDL) mg/dL 4498-2
520194 Glomerulonephritis (GNP) Prof 97564-9 520260 Interpretation: N/A
Order Code520194
Order Code NameGlomerulonephritis (GNP) Prof
Order Loinc97564-9
Result Code520073
Result Code NameAnti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC42254-3
Order Code520194
Order Code NameGlomerulonephritis (GNP) Prof
Order Loinc97564-9
Result Code520150
Result Code NameANCA by IFA (RDL)
UofM
Result LOINC29641-8
Order Code520194
Order Code NameGlomerulonephritis (GNP) Prof
Order Loinc97564-9
Result Code520211
Result Code NameAnti-MPO Ab (RDL)
UofMUnits
Result LOINC46266-3
Order Code520194
Order Code NameGlomerulonephritis (GNP) Prof
Order Loinc97564-9
Result Code520215
Result Code NameAnti-PR-3 Ab (RDL)
UofMUnits
Result LOINC46267-1
Order Code520194
Order Code NameGlomerulonephritis (GNP) Prof
Order Loinc97564-9
Result Code520249
Result Code NameAnti-GBM Ab (RDL)
UofMUnits
Result LOINC31406-2
Order Code520194
Order Code NameGlomerulonephritis (GNP) Prof
Order Loinc97564-9
Result Code520060
Result Code NameAnti-dsDNA Ab by Farr(RDL)
UofMIU/mL
Result LOINC47299-3
Order Code520194
Order Code NameGlomerulonephritis (GNP) Prof
Order Loinc97564-9
Result Code520169
Result Code NameC3 Complement (RDL)
UofMmg/dL
Result LOINC4485-9
Order Code520194
Order Code NameGlomerulonephritis (GNP) Prof
Order Loinc97564-9
Result Code520167
Result Code NameC4 Complement (RDL)
UofMmg/dL
Result LOINC4498-2
Order Code520194
Order Code NameGlomerulonephritis (GNP) Prof
Order Loinc97564-9
Result Code520260
Result Code NameInterpretation:
UofM
Result LOINCN/A
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520074 Homogeneous Pattern 20398-4
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520074
Result NameHomogeneous Pattern
UofM
Result LOINC20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520076 Nucleolar Pattern 20399-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520076
Result NameNucleolar Pattern
UofM
Result LOINC20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520233 Speckled Pattern 20401-6
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520233
Result NameSpeckled Pattern
UofM
Result LOINC20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520234 Centromere Pattern 53993-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520234
Result NameCentromere Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520235 Spindle Apparatus Pattern 53003-0
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520235
Result NameSpindle Apparatus Pattern
UofM
Result LOINC53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520236 Nuclear Membrane Pattern 54006-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520236
Result NameNuclear Membrane Pattern
UofM
Result LOINC54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520237 Midbody Pattern 54155-7
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520237
Result NameMidbody Pattern
UofM
Result LOINC54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520238 Nuclear Dot Pattern 53998-1
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520238
Result NameNuclear Dot Pattern
UofM
Result LOINC53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520239 PCNA Pattern 53006-3
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520239
Result NamePCNA Pattern
UofM
Result LOINC53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520240 Centriole Pattern 53993-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520240
Result NameCentriole Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520241 Note: 77202-0
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520241
Result NameNote:
UofM
Result LOINC77202-0
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520257 Positive ANCA Reflex 520187 C-ANCA (IFA-ETOH) 14277-8
Reflex 1
Order Code520257
Order NamePositive ANCA Reflex
Result Code520187
Result NameC-ANCA (IFA-ETOH)
UofM
Result LOINC14277-8
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520257 Positive ANCA Reflex 520189 P-ANCA (IFA-ETOH) 14278-6
Reflex 1
Order Code520257
Order NamePositive ANCA Reflex
Result Code520189
Result NameP-ANCA (IFA-ETOH)
UofM
Result LOINC14278-6
Reflex Table for ANCA by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520257 Positive ANCA Reflex 520191 P-ANCA (IFA-Formalin) 17357-5
Reflex 1
Order Code520257
Order NamePositive ANCA Reflex
Result Code520191
Result NameP-ANCA (IFA-Formalin)
UofM
Result LOINC17357-5