Find Locations
For hours, walk-ins and appointments.Test Includes
Anti-EJ Ab; Anti-Jo-1 Ab; Anti-OJ Ab; Anti-PL-7 Ab, Anti-PL-12 Ab
Expected Turnaround Time
14 - 21 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Refrigerate or freeze.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x1 |
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Test Details
Use
This Anti-Synthetase Profile is comprised of Anti-Jo-1 Ab, Anti-PL-7 Ab, Anti-PL-12 Ab, Anti-EJ Ab and Anti-OJ Ab. Anti-synthetase syndrome is an autoimmune disease characterized by interstitial lung disease (ILD), non-erosive arthritis, myositis, Raynaud’s phenomenon, unexplained fever and/or mechanic’s hands.1
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
RIPA gel radiography, Enzyme-linked immunosorbent assay (ELISA)
Footnotes
1. Witt LJ, Curran JJ, Strek ME. The diagnosis and treatment of antisynthetase syndrome. Clin Pulm Med. 2016 Sep;23(5):218-226.27594777
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 520193 | Anti-Synthetase Profile (RDL) | Pending | 520259 | Anti-Jo-1 Ab (RDL) | Units | 35333-4 |
| 520193 | Anti-Synthetase Profile (RDL) | Pending | 520046 | Anti-PL-7 Ab (RDL) | 33772-5 | |
| 520193 | Anti-Synthetase Profile (RDL) | Pending | 520049 | Anti-PL-12 Ab (RDL) | 33771-7 | |
| 520193 | Anti-Synthetase Profile (RDL) | Pending | 520027 | Anti-EJ Ab (RDL) | 45149-2 | |
| 520193 | Anti-Synthetase Profile (RDL) | Pending | 520029 | Anti-OJ Ab (RDL) | 45152-6 |
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