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Anti-Synthetase Profile (RDL)

CPT 83516(x4); 86235

Test Details

Methodology

RIPA gel radiography, Enzyme-linked immunosorbent assay (ELISA)

Result Turnaround Time

14 - 21 days

Related Documents

Use

This Anti-Synthetase Profile is comprised of Anti-Jo-1 Ab, Anti-PL-7 Ab, Anti-PL-12 Ab, Anti-EJ Ab and Anti-OJ Ab. Anti-synthetase syndrome is an autoimmune disease characterized by interstitial lung disease (ILD), non-erosive arthritis, myositis, Raynaud’s phenomenon, unexplained fever and/or mechanic’s hands.1

Specimen Requirements

Test Includes

Anti-EJ Ab; Anti-Jo-1 Ab; Anti-OJ Ab; Anti-PL-7 Ab, Anti-PL-12 Ab

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen

Serum

Volume

3 mL

Minimum Volume

1 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Storage Instructions

Refrigerate or freeze.

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

Collection Instructions

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1

Footnotes

1. Witt LJ, Curran JJ, Strek ME. The diagnosis and treatment of antisynthetase syndrome. Clin Pulm Med. 2016 Sep;23(5):218-226.27594777

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520193 Anti-Synthetase Profile (RDL) 97564-9 520259 Anti-Jo-1 Ab (RDL) Units 35333-4
520193 Anti-Synthetase Profile (RDL) 97564-9 520046 Anti-PL-7 Ab (RDL) 33772-5
520193 Anti-Synthetase Profile (RDL) 97564-9 520049 Anti-PL-12 Ab (RDL) 33771-7
520193 Anti-Synthetase Profile (RDL) 97564-9 520027 Anti-EJ Ab (RDL) 45149-2
520193 Anti-Synthetase Profile (RDL) 97564-9 520029 Anti-OJ Ab (RDL) 45152-6
Order Code520193
Order Code NameAnti-Synthetase Profile (RDL)
Order Loinc97564-9
Result Code520259
Result Code NameAnti-Jo-1 Ab (RDL)
UofMUnits
Result LOINC35333-4
Order Code520193
Order Code NameAnti-Synthetase Profile (RDL)
Order Loinc97564-9
Result Code520046
Result Code NameAnti-PL-7 Ab (RDL)
UofM
Result LOINC33772-5
Order Code520193
Order Code NameAnti-Synthetase Profile (RDL)
Order Loinc97564-9
Result Code520049
Result Code NameAnti-PL-12 Ab (RDL)
UofM
Result LOINC33771-7
Order Code520193
Order Code NameAnti-Synthetase Profile (RDL)
Order Loinc97564-9
Result Code520027
Result Code NameAnti-EJ Ab (RDL)
UofM
Result LOINC45149-2
Order Code520193
Order Code NameAnti-Synthetase Profile (RDL)
Order Loinc97564-9
Result Code520029
Result Code NameAnti-OJ Ab (RDL)
UofM
Result LOINC45152-6