ANA Profile 12 (RDL)

Test Number 520188

Test number copied

CPT 86038

Synonyms

ANA 12
ANA 12 Panel

Test Details

Methodology

ELISA, IFA, Farr RIA,CMIA

Result Turnaround Time

10 - 12 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Test Includes

ANA Profile 12 is reflexive and is comprised of Anti-Nuclear Ab (ANA) by IFA, Anti-Cardiolipin Ab (IgG, IgA & IgM Isotypes), Anti-Centromere Ab, Anti-dsDNA Ab by Farr, Anti-La (SS-B) Ab, Anti-Ro (SSA) Ab, Anti-Scl-70 Ab, Anti- Sm, Anti-TPO (Thyroid Microsomal Peroxidase) Ab, Anti-U1 RNP, C3 Complement, C4 Complement.

If ANA is positive, all tests listed are performed. If ANA is negative, an Anti-Ro (SS-A) test is performed to catch the small percentage of ANA false negative results. ANA includes titer & pattern.

Use

The ANA test detects autoantibodies that bind to the nuclear components of HEp-2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic and potential prognostic utility for several autoimmune diseases.

RDL’s ANA 12 Profile Helps Differentiate Between 8 Autoimmune Disease States:

SLE

• ANA by IFA

Tests with high specificity

• Anti-dsDNA by Farr

• Anti-SM

Tests with moderate specificity

• Anti-Ro

• Anti-La

• C3 & C4 Complements

• Anticardiolipin IgG, IgA & IgM

Sjogren’s Syndrome

• Anti-Ro

• Anti-La

Mixed Connective Tissue Disease (MCTD)

• Anti-U1 RNP

Limited Scleroderma (CREST)

• Anti-Centromere

Diffuse Scleroderma

• Anti-SCL-70 by EIA, confirmed by ID

Autoimmune Thyroid Disease

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

4 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection Instructions

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Stability Requirements

Temperature	Period
Room temperature	8 days
Refrigerated	8 days
Frozen	8 days

Storage Instructions

Refrigerate.

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

LOINC® Map

Order Code	Order Code Name	Order Loinc	Result Code	Result Code Name	Result LOINC
520188	ANA Profile 12 (RDL)	42254-3	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Order Code	520188
Order Code Name	ANA Profile 12 (RDL)
Order Loinc	42254-3
Result Code	520073
Result Code Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520219	Anti-Ro/Neg ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520219
Order Name	Anti-Ro/Neg ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520074	Homogeneous Pattern	20398-4
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520074
Result Name	Homogeneous Pattern
UofM
Result LOINC	20398-4

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520076	Nucleolar Pattern	20399-2
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520076
Result Name	Nucleolar Pattern
UofM
Result LOINC	20399-2

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520233	Speckled Pattern	20401-6
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520233
Result Name	Speckled Pattern
UofM
Result LOINC	20401-6

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520234	Centromere Pattern	53993-2
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520234
Result Name	Centromere Pattern
UofM
Result LOINC	53993-2

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520235	Spindle Apparatus Pattern	53003-0
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520235
Result Name	Spindle Apparatus Pattern
UofM
Result LOINC	53003-0

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520236	Nuclear Membrane Pattern	54006-2
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520236
Result Name	Nuclear Membrane Pattern
UofM
Result LOINC	54006-2

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520237	Midbody Pattern	54155-7
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520237
Result Name	Midbody Pattern
UofM
Result LOINC	54155-7

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520238	Nuclear Dot Pattern	53998-1
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520238
Result Name	Nuclear Dot Pattern
UofM
Result LOINC	53998-1

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520239	PCNA Pattern	53006-3
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520239
Result Name	PCNA Pattern
UofM
Result LOINC	53006-3

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520240	Centriole Pattern	53993-2
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520240
Result Name	Centriole Pattern
UofM
Result LOINC	53993-2

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520241	Note:	77202-0
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520241
Result Name	Note:
UofM
Result LOINC	77202-0

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520066	Anti-Centromere Ab by IFA(RDL)	5077-3
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520066
Result Name	Anti-Centromere Ab by IFA(RDL)
UofM
Result LOINC	5077-3

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520060	Anti-dsDNA Ab by Farr(RDL)	IU/mL	47299-3
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520060
Result Name	Anti-dsDNA Ab by Farr(RDL)
UofM	IU/mL
Result LOINC	47299-3

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520216	Anti-Sm Ab (RDL)	Units	11090-8
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520216
Result Name	Anti-Sm Ab (RDL)
UofM	Units
Result LOINC	11090-8

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520217	Anti-U1 RNP Ab (RDL)	Units	57662-9
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520217
Result Name	Anti-U1 RNP Ab (RDL)
UofM	Units
Result LOINC	57662-9

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520218	Anti-Ro (SS-A) Ab (RDL)	Units	33569-5
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520218
Result Name	Anti-Ro (SS-A) Ab (RDL)
UofM	Units
Result LOINC	33569-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520225	Anti-La (SS-B) Ab (RDL)	Units	45142-7
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520225
Result Name	Anti-La (SS-B) Ab (RDL)
UofM	Units
Result LOINC	45142-7

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520221	Anti-Scl-70 Ab (RDL)	Units	26975-3
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520221
Result Name	Anti-Scl-70 Ab (RDL)
UofM	Units
Result LOINC	26975-3

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520223	Anti-Cardiolipin Ab, IgG (RDL)	GPL U/mL	3181-5
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520223
Result Name	Anti-Cardiolipin Ab, IgG (RDL)
UofM	GPL U/mL
Result LOINC	3181-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520182	Anti-Cardiolipin Ab, IgA (RDL)	APL U/mL	5076-5
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520182
Result Name	Anti-Cardiolipin Ab, IgA (RDL)
UofM	APL U/mL
Result LOINC	5076-5

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520183	Anti-Cardiolipin Ab, IgM (RDL)	MPL U/mL	3182-3
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520183
Result Name	Anti-Cardiolipin Ab, IgM (RDL)
UofM	MPL U/mL
Result LOINC	3182-3

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520169	C3 Complement (RDL)	mg/dL	4485-9
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520169
Result Name	C3 Complement (RDL)
UofM	mg/dL
Result LOINC	4485-9

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520167	C4 Complement (RDL)	mg/dL	4498-2
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520167
Result Name	C4 Complement (RDL)
UofM	mg/dL
Result LOINC	4498-2

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	UofM	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520036	Anti-TPO Ab (RDL)	IU/mL	8099-4
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520036
Result Name	Anti-TPO Ab (RDL)
UofM	IU/mL
Result LOINC	8099-4

Reflex Table for Anti-Nuclear Ab by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520179	ANA 12 Profile, Positive ANA	520229	ANA 12 Profile Interpretation	N/A
Reflex 1
Order Code	520179
Order Name	ANA 12 Profile, Positive ANA
Result Code	520229
Result Name	ANA 12 Profile Interpretation
UofM
Result LOINC	N/A

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