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ANA Profile 12 (RDL)

Test Number 520188
Test number copied
CPT 86038
Synonyms
  • ANA 12
  • ANA 12 Panel

Test Details

Methodology

ELISA, IFA, Farr RIA,CMIA

Result Turnaround Time

10 - 12 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Antinuclear Antibodies Testing Options in Rheumatology Brochure

Autoimmune Profiles Brochure

Lupus Comprehensive Testing Brochure

Test Includes

ANA Profile 12 is reflexive and is comprised of Anti-Nuclear Ab (ANA) by IFA, Anti-Cardiolipin Ab (IgG, IgA & IgM Isotypes), Anti-Centromere Ab, Anti-dsDNA Ab by Farr, Anti-La (SS-B) Ab, Anti-Ro (SSA) Ab, Anti-Scl-70 Ab, Anti- Sm, Anti-TPO (Thyroid Microsomal Peroxidase) Ab, Anti-U1 RNP, C3 Complement, C4 Complement.

If ANA is positive, all tests listed are performed. If ANA is negative, an Anti-Ro (SS-A) test is performed to catch the small percentage of ANA false negative results. ANA includes titer & pattern.

Use

The ANA test detects autoantibodies that bind to the nuclear components of HEp-2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic and potential prognostic utility for several autoimmune diseases.

RDL’s ANA 12 Profile Helps Differentiate Between 8 Autoimmune Disease States:

SLE

• ANA by IFA

Tests with high specificity

• Anti-dsDNA by Farr

• Anti-SM

Tests with moderate specificity

• Anti-Ro

• Anti-La

• C3 & C4 Complements

• Anticardiolipin IgG, IgA & IgM

Sjogren’s Syndrome

• Anti-Ro

• Anti-La

Mixed Connective Tissue Disease (MCTD)

• Anti-U1 RNP

Limited Scleroderma (CREST)

• Anti-Centromere

Diffuse Scleroderma

• Anti-SCL-70 by EIA, confirmed by ID

Autoimmune Thyroid Disease

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

4 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection Instructions

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Stability Requirements

Temperature

Period

Room temperature

8 days

Refrigerated

8 days

Frozen

8 days

Storage Instructions

Refrigerate.

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520188 ANA Profile 12 (RDL) 42254-3 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
Order Code520188
Order Code NameANA Profile 12 (RDL)
Order Loinc42254-3
Result Code520073
Result Code NameAnti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC42254-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520219 Anti-Ro/Neg ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520219
Order NameAnti-Ro/Neg ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520074 Homogeneous Pattern 20398-4
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520074
Result NameHomogeneous Pattern
UofM
Result LOINC20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520076 Nucleolar Pattern 20399-2
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520076
Result NameNucleolar Pattern
UofM
Result LOINC20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520233 Speckled Pattern 20401-6
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520233
Result NameSpeckled Pattern
UofM
Result LOINC20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520234 Centromere Pattern 53993-2
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520234
Result NameCentromere Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520235 Spindle Apparatus Pattern 53003-0
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520235
Result NameSpindle Apparatus Pattern
UofM
Result LOINC53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520236 Nuclear Membrane Pattern 54006-2
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520236
Result NameNuclear Membrane Pattern
UofM
Result LOINC54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520237 Midbody Pattern 54155-7
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520237
Result NameMidbody Pattern
UofM
Result LOINC54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520238 Nuclear Dot Pattern 53998-1
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520238
Result NameNuclear Dot Pattern
UofM
Result LOINC53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520239 PCNA Pattern 53006-3
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520239
Result NamePCNA Pattern
UofM
Result LOINC53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520240 Centriole Pattern 53993-2
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520240
Result NameCentriole Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520241 Note: 77202-0
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520241
Result NameNote:
UofM
Result LOINC77202-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520066 Anti-Centromere Ab by IFA(RDL) 5077-3
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520066
Result NameAnti-Centromere Ab by IFA(RDL)
UofM
Result LOINC5077-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520060
Result NameAnti-dsDNA Ab by Farr(RDL)
UofMIU/mL
Result LOINC47299-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520216 Anti-Sm Ab (RDL) Units 11090-8
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520216
Result NameAnti-Sm Ab (RDL)
UofMUnits
Result LOINC11090-8
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520217 Anti-U1 RNP Ab (RDL) Units 57662-9
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520217
Result NameAnti-U1 RNP Ab (RDL)
UofMUnits
Result LOINC57662-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520218
Result NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520225 Anti-La (SS-B) Ab (RDL) Units 45142-7
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520225
Result NameAnti-La (SS-B) Ab (RDL)
UofMUnits
Result LOINC45142-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520221 Anti-Scl-70 Ab (RDL) Units 26975-3
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520221
Result NameAnti-Scl-70 Ab (RDL)
UofMUnits
Result LOINC26975-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520223 Anti-Cardiolipin Ab, IgG (RDL) GPL U/mL 3181-5
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520223
Result NameAnti-Cardiolipin Ab, IgG (RDL)
UofMGPL U/mL
Result LOINC3181-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520182 Anti-Cardiolipin Ab, IgA (RDL) APL U/mL 5076-5
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520182
Result NameAnti-Cardiolipin Ab, IgA (RDL)
UofMAPL U/mL
Result LOINC5076-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520183 Anti-Cardiolipin Ab, IgM (RDL) MPL U/mL 3182-3
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520183
Result NameAnti-Cardiolipin Ab, IgM (RDL)
UofMMPL U/mL
Result LOINC3182-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520169 C3 Complement (RDL) mg/dL 4485-9
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520169
Result NameC3 Complement (RDL)
UofMmg/dL
Result LOINC4485-9
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520167 C4 Complement (RDL) mg/dL 4498-2
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520167
Result NameC4 Complement (RDL)
UofMmg/dL
Result LOINC4498-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520036 Anti-TPO Ab (RDL) IU/mL 8099-4
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520036
Result NameAnti-TPO Ab (RDL)
UofMIU/mL
Result LOINC8099-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520179 ANA 12 Profile, Positive ANA 520229 ANA 12 Profile Interpretation N/A
Reflex 1
Order Code520179
Order NameANA 12 Profile, Positive ANA
Result Code520229
Result NameANA 12 Profile Interpretation
UofM
Result LOINCN/A