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ANA 12 Plus Profile, Do All (RDL)

Test Number 520175
Test number copied
CPT 86038; 86147(x3); 86160(x2); 86200; 86225; 86235(x7); 86376; 86431
Synonyms
  • ANA 12 Plus
  • ANA 12 Plus Panel

Test Details

Methodology

ELISA, IFA, Farr RIA, Turbidimetry, CMIA

Result Turnaround Time

14 - 21 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Autoimmune Profiles Brochure

Antinuclear Antibodies Testing Options in Rheumatology Brochure

Lupus Comprehensive Testing Brochure

Test Includes

This profile is comprised of Anti‐Nuclear Ab (ANA) by IFA, Anti‐dsDNA Ab by Farr, Anti‐ENA Abs (Anti‐Sm & Anti‐RNP), Anti‐Centromere Ab, C3 & C4 Complements, Anti‐Ro (SS‐A) Ab, Anti‐La (SS‐B) Ab, Anti‐Scl‐70 Ab, Anti‐cardiolipin Abs (IgG, IgA & IgM isotypes), Anti‐TPO (Thyroid Microsomal Peroxidase) Ab, Anti‐Chromatin Ab, Rheumatoid Factor by Turb, Anti‐CCP (Cyclic Citrullinated Peptide) Ab.

The reflexive ANA 12 Plus Profile is a separate test (use 520180).

Use

The ANA test detects autoantibodies that bind to the nuclear components of HEp‐2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic andpotential prognostic utility for several autoimmune diseases.

RDL’s ANA 12 Plus Profile Helps Differentiate Between 8 Autoimmune Disease States:

SLE

• ANA by IFA

Tests with high specificity

• Anti‐dsDNA by Farr

• Anti‐SM

Tests with moderate specificity

• Anti‐Ro

• Anti‐La

• Anti‐Chromatin

• C3 & C4 Complements

• Anticardiolipin IgG, IgA & IgM

Drug‐induced SLE

• Anti‐Chromatin

Sjogren’s Syndrome

• Anti‐Ro

• Anti‐La

Rheumatoid Arthritis

• Anti‐CCP (high specificity)

• Rheumatoid Factor (Turbidimetry)

Mixed Connective Tissue Disease (MCTD)

• Anti-U1 RNP

Limited Scleroderma (CREST)

• Anti-Centomere

Diffuse Scleroderma

• Anti-SCL-70 by EIA, confirmed by ID

Autoimmune Thyroid Disease

• Anti-Thyroid Microsomal (TPO)

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Serum

Volume

5 mL

Minimum Volume

4 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection Instructions

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.

Stability Requirements

Temperature

Period

Room temperature

1 day

Refrigerated

8 days

Frozen

8 days

Storage Instructions

Refrigerate.

Causes for Rejection

Grossly hemolyzed, bacterial contamination, lipemic, icteric, non‐serum specimen types

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520175 ANA 12Plus Profile, Do All RDL 97564-9 520073 Anti-Nuclear Ab by IFA (RDL) 42254-3
520175 ANA 12Plus Profile, Do All RDL 97564-9 520066 Anti-Centromere Ab by IFA(RDL) 5077-3
520175 ANA 12Plus Profile, Do All RDL 97564-9 520060 Anti-dsDNA Ab by Farr(RDL) IU/mL 47299-3
520175 ANA 12Plus Profile, Do All RDL 97564-9 520216 Anti-Sm Ab (RDL) Units 11090-8
520175 ANA 12Plus Profile, Do All RDL 97564-9 520217 Anti-U1 RNP Ab (RDL) Units 57662-9
520175 ANA 12Plus Profile, Do All RDL 97564-9 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
520175 ANA 12Plus Profile, Do All RDL 97564-9 520225 Anti-La (SS-B) Ab (RDL) Units 45142-7
520175 ANA 12Plus Profile, Do All RDL 97564-9 520221 Anti-Scl-70 Ab (RDL) Units 26975-3
520175 ANA 12Plus Profile, Do All RDL 97564-9 520223 Anti-Cardiolipin Ab, IgG (RDL) GPL U/mL 3181-5
520175 ANA 12Plus Profile, Do All RDL 97564-9 520182 Anti-Cardiolipin Ab, IgA (RDL) APL U/mL 5076-5
520175 ANA 12Plus Profile, Do All RDL 97564-9 520183 Anti-Cardiolipin Ab, IgM (RDL) MPL U/mL 3182-3
520175 ANA 12Plus Profile, Do All RDL 97564-9 520169 C3 Complement (RDL) mg/dL 4485-9
520175 ANA 12Plus Profile, Do All RDL 97564-9 520167 C4 Complement (RDL) mg/dL 4498-2
520175 ANA 12Plus Profile, Do All RDL 97564-9 520036 Anti-TPO Ab (RDL) IU/mL 8099-4
520175 ANA 12Plus Profile, Do All RDL 97564-9 520224 Anti-Chromatin Ab, IgG (RDL) Units 32580-3
520175 ANA 12Plus Profile, Do All RDL 97564-9 520226 Anti-CCP Ab, IgG + IgA (RDL) Units 57093-7
520175 ANA 12Plus Profile, Do All RDL 97564-9 520132 Rheumatoid Factor by Turb RDL IU/mL 11572-5
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520073
Result Code NameAnti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC42254-3
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520066
Result Code NameAnti-Centromere Ab by IFA(RDL)
UofM
Result LOINC5077-3
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520060
Result Code NameAnti-dsDNA Ab by Farr(RDL)
UofMIU/mL
Result LOINC47299-3
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520216
Result Code NameAnti-Sm Ab (RDL)
UofMUnits
Result LOINC11090-8
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520217
Result Code NameAnti-U1 RNP Ab (RDL)
UofMUnits
Result LOINC57662-9
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520218
Result Code NameAnti-Ro (SS-A) Ab (RDL)
UofMUnits
Result LOINC33569-5
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520225
Result Code NameAnti-La (SS-B) Ab (RDL)
UofMUnits
Result LOINC45142-7
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520221
Result Code NameAnti-Scl-70 Ab (RDL)
UofMUnits
Result LOINC26975-3
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520223
Result Code NameAnti-Cardiolipin Ab, IgG (RDL)
UofMGPL U/mL
Result LOINC3181-5
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520182
Result Code NameAnti-Cardiolipin Ab, IgA (RDL)
UofMAPL U/mL
Result LOINC5076-5
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520183
Result Code NameAnti-Cardiolipin Ab, IgM (RDL)
UofMMPL U/mL
Result LOINC3182-3
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520169
Result Code NameC3 Complement (RDL)
UofMmg/dL
Result LOINC4485-9
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520167
Result Code NameC4 Complement (RDL)
UofMmg/dL
Result LOINC4498-2
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520036
Result Code NameAnti-TPO Ab (RDL)
UofMIU/mL
Result LOINC8099-4
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520224
Result Code NameAnti-Chromatin Ab, IgG (RDL)
UofMUnits
Result LOINC32580-3
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520226
Result Code NameAnti-CCP Ab, IgG + IgA (RDL)
UofMUnits
Result LOINC57093-7
Order Code520175
Order Code NameANA 12Plus Profile, Do All RDL
Order Loinc97564-9
Result Code520132
Result Code NameRheumatoid Factor by Turb RDL
UofMIU/mL
Result LOINC11572-5
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520074 Homogeneous Pattern 20398-4
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520074
Result NameHomogeneous Pattern
UofM
Result LOINC20398-4
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520076 Nucleolar Pattern 20399-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520076
Result NameNucleolar Pattern
UofM
Result LOINC20399-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520233 Speckled Pattern 20401-6
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520233
Result NameSpeckled Pattern
UofM
Result LOINC20401-6
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520234 Centromere Pattern 53993-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520234
Result NameCentromere Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520235 Spindle Apparatus Pattern 53003-0
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520235
Result NameSpindle Apparatus Pattern
UofM
Result LOINC53003-0
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520236 Nuclear Membrane Pattern 54006-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520236
Result NameNuclear Membrane Pattern
UofM
Result LOINC54006-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520237 Midbody Pattern 54155-7
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520237
Result NameMidbody Pattern
UofM
Result LOINC54155-7
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520238 Nuclear Dot Pattern 53998-1
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520238
Result NameNuclear Dot Pattern
UofM
Result LOINC53998-1
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520239 PCNA Pattern 53006-3
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520239
Result NamePCNA Pattern
UofM
Result LOINC53006-3
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520240 Centriole Pattern 53993-2
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520240
Result NameCentriole Pattern
UofM
Result LOINC53993-2
Reflex Table for Anti-Nuclear Ab by IFA (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520077 ANA Titer and Pattern 520241 Note: 77202-0
Reflex 1
Order Code520077
Order NameANA Titer and Pattern
Result Code520241
Result NameNote:
UofM
Result LOINC77202-0
Reflex Table for Anti-Scl-70 Ab (RDL)
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 520341 Repeat Anti-Scl-70 520341 Repeat Anti-Scl-70 5348-8
Reflex 1
Order Code520341
Order NameRepeat Anti-Scl-70
Result Code520341
Result NameRepeat Anti-Scl-70
UofM
Result LOINC5348-8