Anti-Neutrophil Cytoplasmic Ab (ANCA) by Indirect Immunofluorescence (IFA) (RDL)

Test Number 520090

Test number copied

CPT 86036

Synonyms

ANCA Ab
Anti-Neutrophil Cytoplasmic Ab (ANCA)

Test Details

Methodology

Indirect Immunofluorescence (IFA)

Result Turnaround Time

5 - 7 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Test Includes

This test reflexes to Anti-Nuclear Ab by IFA (RDL) if ANCA is positive in order to rule out false positive ANCA due to the presence of ANA.

Use

Although C-ANCA and P-ANCA are typically of the IgG isotype, C-ANCA are frequently reactive with PR-3. P-ANCA frequently react with MPO. ANCA/MPO antibodies are found in 30% in glomerular basement membrane disease (Wegener's Disease). 88% of patients with vasculitis-associated pulmonary hemorrhage have elevated IgM ANCA, whereas no patients who are IgM ANCA-negative have pulmonary hemorrhage. IgA ANCA is associated with Cholangitis, Kawasaki disease, Cystic fibrosis and Henoch-Schonlein purpura.

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Serum

Volume

1 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection Instructions

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple test on frozen samples, please submit separate frozen specimens for each test requested.

Stability Requirements

Temperature	Period
Room temperature	7 days
Refrigerated	14 days
Frozen	60 days
Freeze/thaw cycles	Stable x1

Reference Range

Negative

Storage Instructions

Refrigerate or freeze.

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

LOINC® Map

Order Code	Order Code Name	Order Loinc	Result Code	Result Code Name	Result LOINC
520090	ANCA by IFA (RDL)	35279-9	520071	ANCA by IFA (RDL)	35279-9
Order Code	520090
Order Code Name	ANCA by IFA (RDL)
Order Loinc	35279-9
Result Code	520071
Result Code Name	ANCA by IFA (RDL)
UofM
Result LOINC	35279-9

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520187	C-ANCA (IFA-ETOH)	14277-8
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520187
Result Name	C-ANCA (IFA-ETOH)
UofM
Result LOINC	14277-8

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520189	P-ANCA (IFA-ETOH)	14278-6
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520189
Result Name	P-ANCA (IFA-ETOH)
UofM
Result LOINC	14278-6

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520191	P-ANCA (IFA-Formalin)	17357-5
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520191
Result Name	P-ANCA (IFA-Formalin)
UofM
Result LOINC	17357-5

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Reflex Table for ANCA by IFA (RDL)
	Order Code	Order Name	Result Code	Result Name	Result LOINC
Reflex 1	520245	Positive ANCA Reflex	520073	Anti-Nuclear Ab by IFA (RDL)	42254-3
Reflex 1
Order Code	520245
Order Name	Positive ANCA Reflex
Result Code	520073
Result Name	Anti-Nuclear Ab by IFA (RDL)
UofM
Result LOINC	42254-3

Managing Your Health

Diseases & Therapeutic Areas

Treatment Modalities & Methods

Scientific Lab Disciplines

Labs

Industries