Test Details
Methodology
Enzyme Immunoassay (EIA)
Result Turnaround Time
14 - 21 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
This test is a component of ANA 12 Profile, ANA 12 Plus Profile, Autoimmune Liver Disease Profile.
Use
Chromatin is comprised of native DNA wrapped around the (H2A-H2B-H3-H4)2 histone octamer, with histone H1 and some non-histone proteins associated. The presence of chromatin antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of drug-induced lupus (DIL) and Systemic Lupus Erythematosus (SLE).
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x1 |
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 520063 | Anti-Chromatin Ab, IgG (RDL) | 32580-3 | 520064 | Anti-Chromatin Ab, IgG (RDL) | Units | 32580-3 |
| Order Code | 520063 | |||||
| Order Code Name | Anti-Chromatin Ab, IgG (RDL) | |||||
| Order Loinc | 32580-3 | |||||
| Result Code | 520064 | |||||
| Result Code Name | Anti-Chromatin Ab, IgG (RDL) | |||||
| UofM | Units | |||||
| Result LOINC | 32580-3 |