Test Details
Methodology
RIPA Gel Radiography
Result Turnaround Time
14 - 21 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
The U3-RNP (Fibrillarin) particle is thought to participate in the first step of preribosomal RNA processing. Anti-U3 RNP antibodies have been shown to be highly specific for patients with SSc.
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Custom Additional Information
Anti-Fibrillarin (U3 RNP) antibodies are highly specific for diffuse SSc with a sensitivity of 4-10%. They are associated with isolated pulmonary arterial hypertension, myositis, renal and cardiac manifestations of SSc. 15% of IIM, mostly found in scleroderma/myositis overlap. Found in 4-10% of Diffuse SSc, <2% in Limited SSc, associated with isolated PAH, myositis, cardiac and renal involvement. More prevalent in African-Americans.
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x1 |
Storage Instructions
Refrigerate or freeze.
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 520019 | Anti-U3 RNP (Fibrillarin)(RDL) | 49963-2 | 520020 | Anti-U3 RNP (Fibrillarin)(RDL) | 49963-2 | |
| Order Code | 520019 | |||||
| Order Code Name | Anti-U3 RNP (Fibrillarin)(RDL) | |||||
| Order Loinc | 49963-2 | |||||
| Result Code | 520020 | |||||
| Result Code Name | Anti-U3 RNP (Fibrillarin)(RDL) | |||||
| UofM | ||||||
| Result LOINC | 49963-2 |