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For hours, walk-ins and appointments.Myeloproliferative Neoplasms With Hypereosinophilia, FISH
CPT:
Contact CPT coding department at 800-222-7566, ext. 6-8400.
Test Includes
This test includes FISH Probes, FGFR1, JAK2, PDGFRA and PDGFRB.
Special Instructions
Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form if available.
Expected Turnaround Time
5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Specimen Requirements
Specimen
Blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slides with metaphase and/or interphase nuclei or bone marrow touch prep slides are acceptable for testing
Volume
10 mL blood (adult), 5 mL blood (pediatric), 3 mL bone marrow
Minimum Volume
5 mL blood (adult), 1 mL blood (pediatric), 1 mL bone marrow
Container
Green-top (sodium heparin) tube (pediatric Vacutainer is optimal, lavender-top (EDTA) tube is suboptimal); adjust tube size to sample volume to avoid heparin toxicity
Collection
Transporting to the testing lab at room temperature is acceptable. Do not allow the sample to overheat or freeze. Use a cool pack or Labcorp transport kit if necessary. Specimens should optimally arrive in the laboratory within 48 hours of collection. Indicate date of collection on the test request form.
Stability Requirements
| Temperature | Period |
| Room Temperature | Blood up to 7 days; bone marrow up to 5 days (do not discard samples out of range; send to laboratory for final determination) |
| Refrigerated | Blood up to 7 days; bone marrow up to 5 days (do not discard samples out of range; send to laboratory for final determination) |
| Frozen | Do not freeze |
| Freeze/Thaw Cycle | Do not freeze |
Causes for Rejection
Broken Vacutainer; broken or stained slides; paraffin blocks; paraffin slides; decalcified bone cores; frozen specimen; quantity not sufficient for analysis
Test Details
Use
This test is used for leukemia/lymphoma monitoring of residual disease, transplants and indolent clones.
Limitations
Molecular mutations below the resolution of FISH will not be detected. This test will not detect regions not targeted by FISH probes in this panel.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Fluorescence in situ hybridization (FISH)
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 512287 | MPN w/Hypereosinophilia FISH | 000000 | ||||
| 512287 | MPN w/Hypereosinophilia FISH | 512123 | 11502-2 | |||
| 512287 | MPN w/Hypereosinophilia FISH | 512288 | Specimen Type | 31208-2 | ||
| 512287 | MPN w/Hypereosinophilia FISH | 512289 | Cells Counted | N/A | ||
| 512287 | MPN w/Hypereosinophilia FISH | 512290 | Cells Analyzed | N/A | ||
| 512287 | MPN w/Hypereosinophilia FISH | 512291 | FISH Result | 62356-1 | ||
| 512287 | MPN w/Hypereosinophilia FISH | 512292 | Interpretation | 50398-7 | ||
| 512287 | MPN w/Hypereosinophilia FISH | 512293 | Director Review: | 69965-2 |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf