Skip to main content

Chromosome Five-cell Count plus Microarray (Reveal®), Whole Blood

CPT

81229; 88230; 88260; 88280

Synonyms
  • Abbreviated Blood Chromosome Analysis
  • Microarray, Blood (Reveal®), SNP
  • Share
  • Print
  • Updated on 03/25/2025

Test Details

Methodology

SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb.

SNP microarray analysis is performed using the Cytoscan® HD platform, which uses more than 743,000 SNP probes and 1,953,000 NPCN probes with a median spacing of 0.88 kb.

SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb.

Result Turnaround Time

14 - 17 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Test Includes

DNA extraction; interpretation; limited five-cell high-resolution chromosome analysis (two analyses, one karyotype)

Use

This test will detect chromosomal imbalances that could be associated with developmental delay/congenital anomalies. It provides detection of possible uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent.

Special Instructions

A completed Clinical Questionnaire for SNP Microarray should accompany specimens. Call 800-345-4363 to request the appropriate form, or print/photocopy the form from the Genetics Appendix online.

This test may also be performed on adults. When a child tested with this assay is found to have an abnormal array of unknown clinical significance that may be clarified through parental testing, there will be no charge associated with the follow-up parental testing that is based on the child's results. All other parental follow-up testing will be charged, including (but not limited to) autism susceptibility regions, known microdeletions/microduplications, autosomal recessive deletions/duplications, and large copy-number changes possible and likely pathogenic significance. The child's abnormal array results will indicate whether parental testing will be performed at no charge and will include the appropriate parental follow-up test number. For parental follow-up testing for arrays not performed at LabCorp, call 800-345-4363 to speak to a genetic counselor.

Limitations

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Whole blood

Volume

5 mL (adults), 2 mL (neonates)

4 mL

5 mL (adults), 2 mL (neonates)

Minimum Volume

2 mL (neonatal) (Note: This volume does not allow for repeat testing.)

Container

Green-top (sodium heparin) tube (preferred) or yellow-top (ACD) tube is acceptable

Green-top (heparin) tube (preferred); yellow-top (ACD) tube is acceptable

Green-top (sodium heparin) tube (preferred) or yellow-top (ACD) tube is acceptable

Collection Instructions

Using sterile technique, collect 5 mL of blood into a green-top (sodium heparin) tube or syringe. Invert the tube several times to prevent coagulation. Specimens should be sent the same day as collected. Use of improper anticoagulant fixed specimen, and/or frozen specimen cannot be processed.

Using sterile technique, collect 5 mL of blood into a green-top (sodium heparin) tube or syringe. Invert the tube several times to prevent coagulation. Specimens should be sent the same day as collected. Use of improper anticoagulant fixed specimen, and/or frozen specimen cannot be processed.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Upon receipt, suitability of specimen will be determined by the Cytogenetics laboratory.

Hemolysis; gross contamination; clotted specimen; frozen specimen; fixed specimen; improper or too much anticoagulant

Upon receipt, suitability of specimen will be determined by the Cytogenetics laboratory.

References

Shaikh TH. Oligonucleotide arrays for high-resolution analysis of copy number alteration in mental retardation/multiple congenital anomalies. Genet Med. 2007 Sep; 9(9):617-625.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511535 Blood Chrom 5 Cell Cnt + CMA 052101 Cells Counted 62361-1
511535 Blood Chrom 5 Cell Cnt + CMA 052102 Cells Karyotyped 55199-4
511535 Blood Chrom 5 Cell Cnt + CMA 052103 Cells Analyzed 62360-3
511535 Blood Chrom 5 Cell Cnt + CMA 052116 GTG Band Resolution Achieved 62358-7
511535 Blood Chrom 5 Cell Cnt + CMA 052115 Cytogenetic Diagnosis 62365-2
511535 Blood Chrom 5 Cell Cnt + CMA 052039 Cytogenetic Interpretation 50619-6
511535 Blood Chrom 5 Cell Cnt + CMA 052157 Specimen Type 31208-2
511535 Blood Chrom 5 Cell Cnt + CMA 052041 Director Review: 48672-0
511535 Blood Chrom 5 Cell Cnt + CMA 512123 PDF 11502-2
511535 Blood Chrom 5 Cell Cnt + CMA 510004 Specimen Type 31208-2
511535 Blood Chrom 5 Cell Cnt + CMA 510005 # of Genotyping Targets 62378-5
511535 Blood Chrom 5 Cell Cnt + CMA 510006 Array Type 62376-9
511535 Blood Chrom 5 Cell Cnt + CMA 510007 Diagnosis 62357-9
511535 Blood Chrom 5 Cell Cnt + CMA 510109 Interpretation 62357-9
511535 Blood Chrom 5 Cell Cnt + CMA 510035 Director Review: 48672-0
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code052101
Result Code NameCells Counted
UofM
Result LOINC62361-1
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code052102
Result Code NameCells Karyotyped
UofM
Result LOINC55199-4
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code052103
Result Code NameCells Analyzed
UofM
Result LOINC62360-3
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code052116
Result Code NameGTG Band Resolution Achieved
UofM
Result LOINC62358-7
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code052115
Result Code NameCytogenetic Diagnosis
UofM
Result LOINC62365-2
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code052039
Result Code NameCytogenetic Interpretation
UofM
Result LOINC50619-6
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code052157
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code052041
Result Code NameDirector Review:
UofM
Result LOINC48672-0
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code512123
Result Code NamePDF
UofM
Result LOINC11502-2
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code510004
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code510005
Result Code Name# of Genotyping Targets
UofM
Result LOINC62378-5
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code510006
Result Code NameArray Type
UofM
Result LOINC62376-9
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code510007
Result Code NameDiagnosis
UofM
Result LOINC62357-9
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code510109
Result Code NameInterpretation
UofM
Result LOINC62357-9
Order Code511535
Order Code NameBlood Chrom 5 Cell Cnt + CMA
Order Loinc
Result Code510035
Result Code NameDirector Review:
UofM
Result LOINC48672-0