Thrombotic Risk Profile

TEST: 511403
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CPT: 81240; 81241
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Test Includes

Factor II G20210A DNA analysis (F2 gene - c.*97G>A); Factor V Leiden DNA analysis (F5 gene - c.1691G>A, p.Arg534Gln; Factor II G20210A DNA analysis (F2 gene - c.*97G>A); Factor V Leiden DNA analysis (F5 gene - c.1691G>A, p.Arg534Gln)

Expected Turnaround Time

3 - 5 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

For more information, please view the literature below.

Hemostasis and Thrombosis Test Compendium

    Specimen Requirements

    Specimen

    Whole blood or Labcorp buccal swab kit (buccal swab collection kit contains instructions for use of a buccal swab)

    Volume

    7 mL whole blood or Labcorp buccal swab kit

    Minimum Volume

    3 mL whole blood or two buccal swabs

    Container

    Lavender-top (EDTA) tube, yellow-top (ACD) tube, or Labcorp buccal swab kit

    Storage Instructions

    Maintain specimen at room temperature or refrigerate.

    Causes for Rejection

    Frozen specimen; hemolysis; quantity not sufficient for analysis; improper container; one buccal swab; wet buccal swab

    Test Details

    Use

    Evaluation of patients with venous thrombosis. See Related Information for individual components of this profile.

    Limitations

    Variants analyzed: F5 gene - c.1691G>A (p.Arg534Gln), also known as Factor V Leiden; F2 gene -c.*97G>A, also known as G20210A. Results must be combined with clinical information for the most accurate interpretation. Molecular-based testing is highly accurate, but as in any laboratory test, diagnostic errors may occur. False positive or false negative results may occur for reasons that include genetic variants, blood transfusions, bone marrow transplantation, somatic or tissue specific mosaicism, mislabeled samples, or erroneous representation of family relationships.

    This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

    Methodology

    Polymerase chain reaction (PCR) and gel electrophoresis

    LOINC® Map

    Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
    511403 Thrombotic Risk Profile 511559 Factor V Leiden Mutation 21667-1
    511403 Thrombotic Risk Profile 512258 Reviewed by: 56850-1
    511403 Thrombotic Risk Profile 511218 Factor II, DNA Analysis 24476-4
    511403 Thrombotic Risk Profile 512253 Reviewed by: 56850-1

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    The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf