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Multiple Myeloma Enriched Microarray and Multiple Myeloma FISH

Test Number 510904
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CPT

81277
Synonyms
  • Monoclonal Gammopathy of Undetermined Significance (MGUS)
  • Oncology Array
  • Plasma Cell Leukemia
  • Reveal® MM Enrich CMA
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  • Updated on 03/31/2025

Test Details

Methodology

Fluorescence in situ hybridization (FISH) and plasma cell enrichment. SNP microarray analysis is performed using the Cytoscan® HD platform, which uses more than 743,000 SNP probes and 1,953,000 NPCN probes with a median spacing of 0.88 kb.

Result Turnaround Time

10 - 14 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Test Includes

Fluorescence in situ hybridization (FISH) for multiple myeloma (MM); IgH-CCDN1; FGFR3/IgH; CMAF/IgH; SNP microarray (Reveal®)

Use

This test is a diagnostic test for multiple myeloma. Plasma cell enrichment diagnosis increased as much as 50% to 100%. The FISH results on the enriched assay should not be used as a quantitative assay, since the abnormal cells do not represent the percentage of abnormal cells in the aspirate. The SNP assay will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.

Diagnostic test for multiple myeloma. Plasma cell enrichment diagnosis increased as much as 50% to 100%. The FISH results on the enriched assay should not be used as a quantitative assay, since the abnormal cells do not represent the percentage of abnormal cells in the aspirate. The SNP assay will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.

This test is a diagnostic test for multiple myeloma. Plasma cell enrichment diagnosis increased as much as 50% to 100%. The FISH results on the enriched assay should not be used as a quantitative assay, since the abnormal cells do not represent the percentage of abnormal cells in the aspirate. The SNP assay will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.

Special Instructions

Indicate pertinent clinical diagnosis and previous cytogenetics studies on the test request form.

Limitations

The SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

The SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

The SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Bone marrow

Volume

1 to 3 mL bone marrow

Minimum Volume

1 mL bone marrow (Note: This volume may not allow for repeat testing.)

1 mL bone marrow

1 mL bone marrow (Note: This volume may not allow for repeat testing.)

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity.

Green-top (sodium heparin) tube with bone marrow aspirate.

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity.

Collection Instructions

Utilize sterile technique and Labcorp transport kits when possible.

Utilize sterile technique and Labcorp transport kits when possible.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Whole blood; broken tube; for SNP microarray, quantity not sufficient for analysis, gel-separator tubes, microtainer tubes, fixed cell pellets

Whole blood; broken tube. For SNP microarray, quantity not sufficient for analysis, gel-separator tubes, microtainer tubes, fixed cell pellets.

Whole blood; broken tube; for SNP microarray, quantity not sufficient for analysis, gel-separator tubes, microtainer tubes, fixed cell pellets

References

Fonseca R, Barlogie B, Bataille R, et al. Genetics and cytogenetics of multiple myeloma: A workshop report. Cancer Res. 2004 Feb 15;64:1546-1558.14989251
Fonseca R, Bergsagel PL, Drach J, et al. International Myeloma Working Group molecular classification of multiple myeloma: Spotlight review. Leukemia. 2009 Dec;23(12):2210-2221.19798094
Pozdnyakova O, Crowley-Larsen P, Zota V, Wang SA, Miron PM. Interphase FISH in plasma cell dyscrasia: Increased in abnormality detection with plasma cell enrichment. Cancer Genet Cytogenet. 2009 Mar;189(2):112-117.19215792

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510904 MM Enrich CMA + MM Trans FISH 511435 Specimen Type 31208-2
510904 MM Enrich CMA + MM Trans FISH 510189 # of Genotyping Targets N/A
510904 MM Enrich CMA + MM Trans FISH 510190 Diagnosis 62357-9
510904 MM Enrich CMA + MM Trans FISH 510191 Interpretation 62365-2
510904 MM Enrich CMA + MM Trans FISH 510192 Director Review: 48672-0
510904 MM Enrich CMA + MM Trans FISH 512123 PDF 11502-2
510904 MM Enrich CMA + MM Trans FISH 510816 Specimen Type 31208-2
510904 MM Enrich CMA + MM Trans FISH 510817 Cells Counted 62361-1
510904 MM Enrich CMA + MM Trans FISH 510818 Cells Analyzed 62360-3
510904 MM Enrich CMA + MM Trans FISH 510819 FISH Result 62357-9
510904 MM Enrich CMA + MM Trans FISH 510964 Interpretation 62365-2
510904 MM Enrich CMA + MM Trans FISH 510973 Director Review: 48672-0
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code511435
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510189
Result Code Name# of Genotyping Targets
UofM
Result LOINCN/A
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510190
Result Code NameDiagnosis
UofM
Result LOINC62357-9
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510191
Result Code NameInterpretation
UofM
Result LOINC62365-2
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510192
Result Code NameDirector Review:
UofM
Result LOINC48672-0
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code512123
Result Code NamePDF
UofM
Result LOINC11502-2
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510816
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510817
Result Code NameCells Counted
UofM
Result LOINC62361-1
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510818
Result Code NameCells Analyzed
UofM
Result LOINC62360-3
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510819
Result Code NameFISH Result
UofM
Result LOINC62357-9
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510964
Result Code NameInterpretation
UofM
Result LOINC62365-2
Order Code510904
Order Code NameMM Enrich CMA + MM Trans FISH
Order Loinc
Result Code510973
Result Code NameDirector Review:
UofM
Result LOINC48672-0