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SNP Microarray−Oncology (Reveal®)

CPT 81277
Synonyms
  • Reveal® Microarray

Test Details

Methodology

SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses more than 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb.

Result Turnaround Time

10 - 14 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Use

This test will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.

Special Instructions

Pertinent medical findings should accompany the test request form.

Limitations

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

References

Gunnarsson R, Staaf J, Jansson M, et al. Screening for copy-number alterations and loss of heterozygosity in chronic lymphocytic leukemia−A comparative study of four differently designed, high resolution microarray platforms. Genes Chromosomes Cancer. 2008 Aug; 47(8):697-711.18484635

Specimen Requirements

Specimen

Whole blood, bone marrow, or nonfixed tumor tissue

Volume

4 mL whole blood, 2 mL bone marrow, or >2 to 4 mm3 tissue

Minimum Volume

2 mL whole blood or 1 mL bone marrow for array only (Note: This volume does not allow for repeat testing.)

Container

Green-top (heparin) tube (preferred), yellow-top (ACD) tube, or lavender-top (EDTA) tube; sterile container containing sterile saline, Ringer's lactate, or Hanks' balanced salt solution or transport medium provided by the cytogenetic laboratory

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Quantity not sufficient for analysis; gel-separator tubes; microtainer tubes; fixed cell pellets

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
510146 Reveal (R) SNP CMA - Oncology 510139 Specimen Type 31208-2
510146 Reveal (R) SNP CMA - Oncology 510147 # of Genotyping Targets N/A
510146 Reveal (R) SNP CMA - Oncology 510218 Diagnosis 62357-9
510146 Reveal (R) SNP CMA - Oncology 510159 Interpretation 62365-2
510146 Reveal (R) SNP CMA - Oncology 510161 Director Review: 48672-0
510146 Reveal (R) SNP CMA - Oncology 512123 PDF 11502-2
Order Code510146
Order Code NameReveal (R) SNP CMA - Oncology
Order Loinc
Result Code510139
Result Code NameSpecimen Type
UofM
Result LOINC31208-2
Order Code510146
Order Code NameReveal (R) SNP CMA - Oncology
Order Loinc
Result Code510147
Result Code Name# of Genotyping Targets
UofM
Result LOINCN/A
Order Code510146
Order Code NameReveal (R) SNP CMA - Oncology
Order Loinc
Result Code510218
Result Code NameDiagnosis
UofM
Result LOINC62357-9
Order Code510146
Order Code NameReveal (R) SNP CMA - Oncology
Order Loinc
Result Code510159
Result Code NameInterpretation
UofM
Result LOINC62365-2
Order Code510146
Order Code NameReveal (R) SNP CMA - Oncology
Order Loinc
Result Code510161
Result Code NameDirector Review:
UofM
Result LOINC48672-0
Order Code510146
Order Code NameReveal (R) SNP CMA - Oncology
Order Loinc
Result Code512123
Result Code NamePDF
UofM
Result LOINC11502-2