Test Details
Methodology
SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb.
Result Turnaround Time
12 - 18 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This test will detect chromosomal imbalance that could be associated with developmental delay/congenital anomalies. It provides possible detection of uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent. It will also allow the detection of complete or partial molar pregnancies.
Special Instructions
Pertinent medical findings must accompany test request form. For formalin fixed paraffin embedded blocks or slides, test number will be updated to Microarray-Products of Conception (POC) Reveal® FFPE [511997]. If <8 mg nonfixed tissue is received, sample will be assessed to run on the Oncoscan Microarray platform, and test number adjusted as necessary and client notified.
If prior NIPT studies have been performed, include copy of the report.
Limitations
Unable to determine genotypes on some formalin-fixed tissue (blocks/slides), allowing only genomic dosage to be determined. This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Custom Additional Information
The microarray will detect DNA copy-number changes at a threshold >1 Mb for deletions, >2 Mb for duplications.
Specimen Requirements
Specimen
Preferred nonfixed tissue or products of conception (POC)/placental villus biopsy
Volume
>8 mg tissue
Container
The transport tube (a sterile specimen container with transport medium) is available from Labcorp. Please call customer service at 800-345-4363. (Do not use isotonic saline as a transport medium or urine containers for shipping.) Specialized kits are now available for POC microarray testing. To order, please contact your local Labcorp representative (PeopleSoft No. 89063, catalogue item ID No. 39025G).
Collection Instructions
Aseptically obtain a small piece of fetal tissue that does not appear necrotic. If specimen is a POC, placental villi or membranes may be the only fetal-derived tissue available, and an effort should be made to submit these tissues rather than maternal decidua.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Quantity not sufficient for analysis; necrotic tissue submitted
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 510110 | POC/Tissue Microarray | 96984-0 | 510112 | Specimen Type | 31208-2 | |
| 510110 | POC/Tissue Microarray | 96984-0 | 510113 | # of Genotyping Targets | N/A | |
| 510110 | POC/Tissue Microarray | 96984-0 | 510114 | Array Type | 96984-0 | |
| 510110 | POC/Tissue Microarray | 96984-0 | 510116 | Diagnosis | 48000-4 | |
| 510110 | POC/Tissue Microarray | 96984-0 | 510117 | Interpretation | 62365-2 | |
| 510110 | POC/Tissue Microarray | 96984-0 | 510118 | Director Review: | 48672-0 | |
| 510110 | POC/Tissue Microarray | 96984-0 | 512123 | 11502-2 | ||
| Order Code | 510110 | |||||
| Order Code Name | POC/Tissue Microarray | |||||
| Order Loinc | 96984-0 | |||||
| Result Code | 510112 | |||||
| Result Code Name | Specimen Type | |||||
| UofM | ||||||
| Result LOINC | 31208-2 | |||||
| Order Code | 510110 | |||||
| Order Code Name | POC/Tissue Microarray | |||||
| Order Loinc | 96984-0 | |||||
| Result Code | 510113 | |||||
| Result Code Name | # of Genotyping Targets | |||||
| UofM | ||||||
| Result LOINC | N/A | |||||
| Order Code | 510110 | |||||
| Order Code Name | POC/Tissue Microarray | |||||
| Order Loinc | 96984-0 | |||||
| Result Code | 510114 | |||||
| Result Code Name | Array Type | |||||
| UofM | ||||||
| Result LOINC | 96984-0 | |||||
| Order Code | 510110 | |||||
| Order Code Name | POC/Tissue Microarray | |||||
| Order Loinc | 96984-0 | |||||
| Result Code | 510116 | |||||
| Result Code Name | Diagnosis | |||||
| UofM | ||||||
| Result LOINC | 48000-4 | |||||
| Order Code | 510110 | |||||
| Order Code Name | POC/Tissue Microarray | |||||
| Order Loinc | 96984-0 | |||||
| Result Code | 510117 | |||||
| Result Code Name | Interpretation | |||||
| UofM | ||||||
| Result LOINC | 62365-2 | |||||
| Order Code | 510110 | |||||
| Order Code Name | POC/Tissue Microarray | |||||
| Order Loinc | 96984-0 | |||||
| Result Code | 510118 | |||||
| Result Code Name | Director Review: | |||||
| UofM | ||||||
| Result LOINC | 48672-0 | |||||
| Order Code | 510110 | |||||
| Order Code Name | POC/Tissue Microarray | |||||
| Order Loinc | 96984-0 | |||||
| Result Code | 512123 | |||||
| Result Code Name | ||||||
| UofM | ||||||
| Result LOINC | 11502-2 |