Autoimmune Neurology/Comprehensive Paraneoplastic Profile, Spinal Fluid

TEST: 505605
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CPT: 86255(x22); 86341; 86051
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Synonyms

  • Antineural Autoantibodies CSF Test
  • Autoimmune Paraneoplastic CSF Panel
  • Paraneoplastic
  • Paraneoplastic Syndrome CSF Test

Special Instructions

If reflex test is performed, additional charges/CPT code(s) may apply.

Expected Turnaround Time

4 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Cerebrospinal fluid (CSF)

Volume

2 mL

Minimum Volume

1 mL

Container

Sterile plastic tube

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Gross hemolysis; grossly lipemic; gross icterus

Test Details

Use

This test is used for the detection of antineuronal autoantibodies that help in the diagnosis of paraneoplastic syndromes and autoimmune encephalopathies and related conditions.

Limitations

This test was developed and its performance characteristics determined by Labcorp in accordance with CLIA requirements. This test has not been cleared or approved by the Food and Drug Administration.

Methodology

Immunofluorescence, Immunoblot

Additional Information

Autoimmune Neurology/Paraneoplastic CSF profile is a broad autoantibody panel that is more likely to capture causative autoantibodies and should be considered, especially when the clinical presentation is unclear, is shared by multiple antibodies, or has overlapping features of paraneoplastic syndrome or several autoimmune neuropathies. Early specific autoantibody diagnosis and appropriate intervention, despite the initial cost of broader testing, may be cost effective in the longer term given the devastating nature of many of these diseases.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
505605 Autoimmune Neurology Ab CSF 94818-2 505562 Interpretation 56850-1
505605 Autoimmune Neurology Ab CSF 94818-2 505611 Anti-Hu Ab 44768-0
505605 Autoimmune Neurology Ab CSF 94818-2 505612 Anti-Ri Ab 56959-0
505605 Autoimmune Neurology Ab CSF 94818-2 505613 Antineuronal nuclear Ab Type 3 90836-8
505605 Autoimmune Neurology Ab CSF 94818-2 505616 PCA Type-1 (Anti-Yo) Ab 14247-1
505605 Autoimmune Neurology Ab CSF 94818-2 505617 Purkinje Cell Cyto Ab Type 2 90843-4
505605 Autoimmune Neurology Ab CSF 94818-2 505618 Purkinje Cell Cyto Ab Type Tr 90845-9
505605 Autoimmune Neurology Ab CSF 94818-2 505619 Amphiphysin Antibody 90815-2
505605 Autoimmune Neurology Ab CSF 94818-2 505621 CRMP-5 IgG 63216-6
505605 Autoimmune Neurology Ab CSF 94818-2 505623 AGNA-1 90827-7
505605 Autoimmune Neurology Ab CSF 94818-2 505624 DPPX Antibody 82989-5
505605 Autoimmune Neurology Ab CSF 94818-2 505626 mGluR1 Antibody 93500-7
505605 Autoimmune Neurology Ab CSF 94818-2 505697 IgLON5 Antibody 96481-7
505605 Autoimmune Neurology Ab CSF 94818-2 505698 Ma2/Ta Antibody 90832-7
505605 Autoimmune Neurology Ab CSF 94818-2 505699 Zic4 Antibody 101229-3
505605 Autoimmune Neurology Ab CSF 94818-2 505702 DNER Antibody 90844-2
505605 Autoimmune Neurology Ab CSF 94818-2 505703 ITPR1 Antibody 96467-6
505605 Autoimmune Neurology Ab CSF 94818-2 505628 AMPA-R1 Antibody 82735-2
505605 Autoimmune Neurology Ab CSF 94818-2 505629 AMPA-R2 Antibody 82987-9
505605 Autoimmune Neurology Ab CSF 94818-2 505632 GABA-B-R Antibody 90825-1
505605 Autoimmune Neurology Ab CSF 94818-2 505633 NMDA-R Antibody 82988-7
505605 Autoimmune Neurology Ab CSF 94818-2 505634 GAD65 Antibody 94711-9
505605 Autoimmune Neurology Ab CSF 94818-2 505706 Aquaporin 4 Ab CSF 90817-8
505605 Autoimmune Neurology Ab CSF 94818-2 505636 CASPR2 Antibody,Cell-based IFA 90820-2
505605 Autoimmune Neurology Ab CSF 94818-2 505637 LGI1 Antibody, Cell-based IFA 90830-1
Reflex Table for Anti-Hu Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505563 Anti-Hu Ab Line Blot 505563 Anti-Hu Ab Line Blot Pending
Reflex Table for Anti-Ri Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505564 Anti-Ri Ab Line Blot 505564 Anti-Ri Ab Line Blot Pending
Reflex Table for PCA Type-1 (Anti-Yo) Ab
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505566 Anti-Yo Ab Line Blot 505566 Anti-Yo Ab Line Blot Pending
Reflex Table for Purkinje Cell Cyto Ab Type Tr
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505567 PCA-Tr Line Blot 505567 PCA-Tr Line Blot Pending
Reflex Table for Amphiphysin Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505568 Amphiphysin Line Blot 505568 Amphiphysin Line Blot Pending
Reflex Table for CRMP-5 IgG
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505622 CRMP-5 IgG Line Blot 505622 CRMP-5 IgG Line Blot 53707-6
Reflex Table for AGNA-1
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505569 AGNA-1 Line Blot 505569 AGNA-1 Line Blot Pending
Reflex Table for DPPX Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505571 DPPX Cell-based IFA 505571 DPPX Cell-based IFA Pending
Reflex 2 505572 DPPX Antibody, Titer 505572 DPPX Antibody, Titer Pending
Reflex Table for mGluR1 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505574 mGluR1 Cell-based IFA 505574 mGluR1 Cell-based IFA 93498-4
Reflex 2 505576 mGluR1 IF Titer 505576 mGluR1 IF Titer 93499-2
Reflex Table for IgLON5 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505694 IgLON5 Cell-based IFA 505694 IgLON5 Cell-based IFA Pending
Reflex 2 505693 IgLON5 IF Titer 505693 IgLON5 IF Titer Pending
Reflex Table for Ma2/Ta Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505692 Ma2/Ta Line Blot 505692 Ma2/Ta Line Blot Pending
Reflex Table for Zic4 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505696 Zic4 Line Blot 505696 Zic4 Line Blot Pending
Reflex Table for DNER Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505643 DNER Line Blot 505643 DNER Line Blot Pending
Reflex Table for ITPR1 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505639 ITPR1 Cell-based IFA 505639 ITPR1 Cell-based IFA Pending
Reflex 2 505638 ITPR1 IF Titer 505638 ITPR1 IF Titer Pending
Reflex Table for AMPA-R1 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505589 AMPA-R-1 Cell-based IFA 505589 AMPA-R-1 Cell-based IFA 90811-1
Reflex 2 505591 AMPA-R-1 IF Titer 505591 AMPA-R-1 IF Titer 95604-5
Reflex Table for AMPA-R2 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505593 AMPA-R-2 Cell-based IFA 505593 AMPA-R-2 Cell-based IFA 93491-9
Reflex 2 505596 AMPA-R-2 IF Titer 505596 AMPA-R-2 IF Titer Pending
Reflex Table for GABA-B-R Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505597 GABA-B Receptor Cell-based IFA 505597 GABA-B Receptor Cell-based IFA 93426-5
Reflex 2 505598 GABA-B Receptor Antibody Titer 505598 GABA-B Receptor Antibody Titer Pending
Reflex Table for NMDA-R Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505599 NMDAR Antibody, Cell-based IFA 505599 NMDAR Antibody, Cell-based IFA 82988-7
Reflex 2 505606 Anti-NMDAR Antibody Titer 505606 Anti-NMDAR Antibody Titer Pending
Reflex Table for GAD65 Antibody
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505607 GAD65 Line Blot 505607 GAD65 Line Blot Pending
Reflex Table for CASPR2 Antibody,Cell-based IFA
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505608 Anti-CASPR2 Antibody Titer 505608 Anti-CASPR2 Antibody Titer Pending
Reflex Table for LGI1 Antibody, Cell-based IFA
Order Code Order Name Result Code Result Name UofM Result LOINC
Reflex 1 505609 Anti-LGI1 Antibody Titer 505609 Anti-LGI1 Antibody Titer Pending

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