Test Details
Methodology
Immunofluorescence (IFA)
Result Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Voltage-Gated Potassium Channel (VGKC) antibodies (predominately Anti-LGI1 and Anti-CASPR2) are associated with paraneoplastic neurological syndromes and limbic encephalitis. These antibodies may also be found in other conditions such as acquired neurmyotonia, painful neuropathy, Morvan's syndrome, and rare tumors (eg, thymoma, small-cell lung cancer).
This indirect fluorescent antibody assay utilizes LGI1 and CASPR2 transfected cell lines for the detection and semi-quantification of autoantibodies.
Special Instructions
If reflex test is performed, additional charges/CPT code(s) may apply.
Limitations
Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established product or procedure.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Specimen Requirements
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Gel-barrier tube, red-top tube, serum gel tube, serum transfer tube
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 14 days |
Freeze/thaw cycles | Stable x3 |
Storage Instructions
Room temperature
Causes for Rejection
CSF or plasma; contaminated, hemolyzed or severely lipemic specimens
References
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 505499 | Anti-VGKC Complex, Serum | 505356 | LGI1 Antibody, Cell-based IFA | 82978-8 | ||
| 505499 | Anti-VGKC Complex, Serum | 505431 | CASPR2 Antibody,Cell-based IFA | 82979-6 | ||
| Order Code | 505499 | |||||
| Order Code Name | Anti-VGKC Complex, Serum | |||||
| Order Loinc | ||||||
| Result Code | 505356 | |||||
| Result Code Name | LGI1 Antibody, Cell-based IFA | |||||
| UofM | ||||||
| Result LOINC | 82978-8 | |||||
| Order Code | 505499 | |||||
| Order Code Name | Anti-VGKC Complex, Serum | |||||
| Order Loinc | ||||||
| Result Code | 505431 | |||||
| Result Code Name | CASPR2 Antibody,Cell-based IFA | |||||
| UofM | ||||||
| Result LOINC | 82979-6 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 505357 | Anti-LGI1 Antibody Titer,Serum | 505357 | Anti-LGI1 Antibody Titer,Serum | 90831-9 | |
| Reflex 1 | ||||||
| Order Code | 505357 | |||||
| Order Name | Anti-LGI1 Antibody Titer,Serum | |||||
| Result Code | 505357 | |||||
| Result Name | Anti-LGI1 Antibody Titer,Serum | |||||
| UofM | ||||||
| Result LOINC | 90831-9 | |||||
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 505432 | Anti-CASPR2 Antibody Titer | 505432 | Anti-CASPR2 Antibody Titer | 95600-3 | |
| Reflex 1 | ||||||
| Order Code | 505432 | |||||
| Order Name | Anti-CASPR2 Antibody Titer | |||||
| Result Code | 505432 | |||||
| Result Name | Anti-CASPR2 Antibody Titer | |||||
| UofM | ||||||
| Result LOINC | 95600-3 | |||||