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- Vectra® DA Disease Activity Test
Expected Turnaround Time
6 - 8 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Specimen Requirements
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Gel-barrier tube, red-top tube or serum transfer tube
Collection
Allow specimen to clot for 30 minutes. Centrifuge and separate from cells within 45 minutes of draw. Transfer to a plastic transport tube before shipping.
Storage Instructions
Ship on frozen cool packs or dry ice. Ship with enough dry ice so ice exists upon receipt of package. Samples cannot go above room temperature.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 3 days |
Refrigerated | 14 days |
Frozen | 326 days |
Causes for Rejection
Gross hemolysis; gross lipemia; improper labeling; patients less than 18 years old or more than 100 years old
Test Details
Use
Vectra® DA measures the concentration of 12 serum proteins. An algorithm is applied to these concentrations to calculate a quantitate disease activity score ranging from 1 to 100. Test results are intended to aid in the assessment of disease activity in RA patients when used in conjunction with standard clinical assessment. This test is not intended or validated to diagnose RA.
An order for Vectra® DA includes and requires an order for 12 biomarkers: VCAM-1, EGF, VEGF-A, IL-6, TNF-RI, MMP-1, YKL-40, Leptin, Resistin, SAA, CRP. These 12 biomarkers are required to generate the Vectra® DA test score. By ordering Vectra® DA, you are ordering all 12 biomarkers and are acknowledging that Labcorp cannot provide a Vectra® DA test result without these 12 biomarkers. Vectra® DA was validated in adults with Rheumatoid Arthritis (RA).
Methodology
Multiplex bead-based immunoassay and Meso Scale Discovery Multi-array Platform
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 504965 | Vectra(R) | 75635-3 | 504966 | Vectra Score | 75633-8 | |
| 504965 | Vectra(R) | 75635-3 | 504967 | Risk of Radiographic Progress | % | N/A |
| 504965 | Vectra(R) | 75635-3 | 504969 | Vectra(R) Level | 75634-6 | |
| 504965 | Vectra(R) | 75635-3 | 504968 | Test Description | N/A | |
| 504965 | Vectra(R) | 75635-3 | 504973 | SAA Result | ug/mL | 1847-3 |
| 504965 | Vectra(R) | 75635-3 | 504974 | CRP Result | mg/L | 1988-5 |
| 504965 | Vectra(R) | 75635-3 | 504975 | VCAM-1 Result | ug/mL | 75627-0 |
| 504965 | Vectra(R) | 75635-3 | 504976 | IL-6 Result | pg/mL | 26881-3 |
| 504965 | Vectra(R) | 75635-3 | 504977 | TNF-RI Result | ng/mL | 75629-6 |
| 504965 | Vectra(R) | 75635-3 | 504978 | EGF Result | pg/mL | 14049-1 |
| 504965 | Vectra(R) | 75635-3 | 504979 | VEGF-A Result | pg/mL | 75628-8 |
| 504965 | Vectra(R) | 75635-3 | 504981 | Leptin Result | ng/mL | 21365-2 |
| 504965 | Vectra(R) | 75635-3 | 504982 | Resistin Result | ng/mL | 75632-0 |
| 504965 | Vectra(R) | 75635-3 | 504983 | MMP-1 Result | ng/mL | 75630-4 |
| 504965 | Vectra(R) | 75635-3 | 504984 | MMP3 Result | ng/mL | 75631-2 |
| 504965 | Vectra(R) | 75635-3 | 504985 | YKL-40 Result | ng/mL | 48663-9 |
| 504965 | Vectra(R) | 75635-3 | 504999 | Biomarker Comment: | N/A | |
| 504965 | Vectra(R) | 75635-3 | 504986 | Footnote/History | N/A | |
| 504965 | Vectra(R) | 75635-3 | 504970 | Clinical Validation | N/A | |
| 504965 | Vectra(R) | 75635-3 | 504997 | Vectra(R) PDF | 11502-2 |
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The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf