Test Details
Methodology
Clotting, platelet agglutination, latex immunoagglutination
Result Turnaround Time
3 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This profile is designed to assess the response of DDAVP treatment in patients presenting with Von Willebrand Disease by measuring VWF and factor VIII levels pre-treatment (baseline) and at two time-points (1 hr and 4 hr) post-treatment. Post-treatment VWF levels are evaluated against baseline results to determine whether the response is adequate and sustained. Results should be correlated with clinical symptoms and family history.
Custom Additional Information
This profile contains testing for FVIII Activity, VWF Activity and VWF Antigen at three timepoints: baseline, 1 hour and 4 hours post-treatment with DDAVP. It also contains a pathologist Interpretation of all test results.
Specimen Requirements
Specimen
Citrated plasma, frozen
Volume
2 mL per timepoint
Minimum Volume
1.5 mL per timepoint (Note: This volume does not allow for repeat testing.)
Container
Blue-top (sodium citrate) tube
Collection Instructions
Centrifuge at 2500 xg for 10 minutes. Separate plasma from cells within 3 hours of venipuncture. Centrifuge plasma a second time and place in plastic transport tubes. Freeze within 4 hours and keep frozen until testing is performed.
Stability Requirements
Temperature | Period |
|---|---|
Frozen | 6 months |
Freeze/thaw cycles | Stable x1 |
Storage Instructions
Plasma, frozen
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 504836 | DDAVP Challenge for VWD | 500684 | Pathologist Interpretation | 21026-0 | ||
| 504836 | DDAVP Challenge for VWD | 504841 | Factor VIII Act, Timepoint 1 | % | 3209-4 | |
| 504836 | DDAVP Challenge for VWD | 504831 | vWF Activity, Timepoint 1 | % | 6014-5 | |
| 504836 | DDAVP Challenge for VWD | 504827 | vWF Antigen, Timepoint 1 | % | 27816-8 | |
| 504836 | DDAVP Challenge for VWD | 504842 | Factor VIII Act, Timepoint 2 | % | 3209-4 | |
| 504836 | DDAVP Challenge for VWD | 504832 | vWF Activity, Timepoint 2 | % | 6014-5 | |
| 504836 | DDAVP Challenge for VWD | 504828 | vWF Antigen, Timepoint 2 | % | 27816-8 | |
| 504836 | DDAVP Challenge for VWD | 504843 | Factor VIII Act, Timepoint 3 | % | 3209-4 | |
| 504836 | DDAVP Challenge for VWD | 504833 | vWF Activity, Timepoint 3 | % | 6014-5 | |
| 504836 | DDAVP Challenge for VWD | 504829 | vWF Antigen, Timepoint 3 | % | 27816-8 | |
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 500684 | |||||
| Result Code Name | Pathologist Interpretation | |||||
| UofM | ||||||
| Result LOINC | 21026-0 | |||||
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 504841 | |||||
| Result Code Name | Factor VIII Act, Timepoint 1 | |||||
| UofM | % | |||||
| Result LOINC | 3209-4 | |||||
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 504831 | |||||
| Result Code Name | vWF Activity, Timepoint 1 | |||||
| UofM | % | |||||
| Result LOINC | 6014-5 | |||||
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 504827 | |||||
| Result Code Name | vWF Antigen, Timepoint 1 | |||||
| UofM | % | |||||
| Result LOINC | 27816-8 | |||||
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 504842 | |||||
| Result Code Name | Factor VIII Act, Timepoint 2 | |||||
| UofM | % | |||||
| Result LOINC | 3209-4 | |||||
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 504832 | |||||
| Result Code Name | vWF Activity, Timepoint 2 | |||||
| UofM | % | |||||
| Result LOINC | 6014-5 | |||||
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 504828 | |||||
| Result Code Name | vWF Antigen, Timepoint 2 | |||||
| UofM | % | |||||
| Result LOINC | 27816-8 | |||||
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 504843 | |||||
| Result Code Name | Factor VIII Act, Timepoint 3 | |||||
| UofM | % | |||||
| Result LOINC | 3209-4 | |||||
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 504833 | |||||
| Result Code Name | vWF Activity, Timepoint 3 | |||||
| UofM | % | |||||
| Result LOINC | 6014-5 | |||||
| Order Code | 504836 | |||||
| Order Code Name | DDAVP Challenge for VWD | |||||
| Order Loinc | ||||||
| Result Code | 504829 | |||||
| Result Code Name | vWF Antigen, Timepoint 3 | |||||
| UofM | % | |||||
| Result LOINC | 27816-8 |