Test Details
Methodology
LC-MS/MS
Result Turnaround Time
7 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
This assay measures the whole blood concentration of hydroxychloroquine. Monitoring HCQ may improve adherence, and whole blood HCQ concentrations may be useful in titrating dose to achieve maximal clinical benefit in lupus while minimizing long-term retinal toxicity in lupus and other chronic autoimmune diseases.
In lupus, RA and other autoimmune diseases, several weeks or months may be required to reach maximum therapeutic benefit that correlates with whole blood HCQ measurement.
Special Instructions
This assay which measures whole blood HCQ is the preferred assay for evaluation of lupus and other autoimmune patients on daily hydroxychloroquine.
This test should be ordered after 3 - 6 months of daily HCQ to assess daily dosage in lupus where drug action and efficacy are cumulative. In lupus, several weeks or months may be required to reach maximum therapeutic benefit that correlates with whole blood HCQ measurement.
Limitations
This test should be ordered after 3 - 6 months of daily HCQ to assess daily dosage in lupus, RA and other autoimmune diseases.
References
Specimen Requirements
Specimen
Whole blood
Volume
1.0 mL
Minimum Volume
0.4 mL (Note: This volume does not allow for repeat testing.)
Container
Lavender-top (EDTA) tube
Collection Instructions
Collect whole blood into lavender-top (EDTA) tube. Refrigerate immediately.
Stability Requirements
Temperature | Period |
---|---|
Room temperature | 15 days |
Refrigerated | 15 days |
Storage Instructions
Refrigerate.
Causes for Rejection
Frozen specimens
LOINC® Map
Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
---|---|---|---|---|---|---|
504814 | Hydroxychloroquine, WB | 95921-3 | 504824 | Hydroxychloroquine, WB | ng/mL | 95921-3 |
Order Code | 504814 | |||||
Order Code Name | Hydroxychloroquine, WB | |||||
Order Loinc | 95921-3 | |||||
Result Code | 504824 | |||||
Result Code Name | Hydroxychloroquine, WB | |||||
UofM | ng/mL | |||||
Result LOINC | 95921-3 |