Test Details
Methodology
ELISA
Result Turnaround Time
7 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Use
Addison's disease (chronic primary adrenal insufficiency) is commonly caused by autoimmune destruction of the adrenal cortex and is characterized by the presence of adrenal cortex autoantibodies in the serum. It can occur sporadically or in combination with other autoimmune endocrine diseases that together comprise Type I or Type II autoimmune polyglandular syndrome. The microsomal autoantigen, steroid 21-hydroxylase enzyme, has been shown to be the primary autoantigen associated with autoimmune Addison's disease. Measurement of 21-hydroxylase autoantibodies aids in diagnosis and management of patients with adrenal insufficiency.
Specimen Requirements
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.2 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel tube
Collection Instructions
Separate serum from cells within one hour. Transfer to a plastic transport tube before freezing. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 14 days |
Refrigerated | 14 days |
Frozen | 2 years |
Freeze/thaw cycles | Stable x6 |
Storage Instructions
Frozen or cold pack
Causes for Rejection
Lipemic or grossly hemolyzed serum samples
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 504805 | 21-Hydroxylase Antibodies | 85363-0 | 504806 | 21-Hydroxylase Antibodies | 85363-0 | |
| Order Code | 504805 | |||||
| Order Code Name | 21-Hydroxylase Antibodies | |||||
| Order Loinc | 85363-0 | |||||
| Result Code | 504806 | |||||
| Result Code Name | 21-Hydroxylase Antibodies | |||||
| UofM | ||||||
| Result LOINC | 85363-0 |