Androsterone

TEST: 504005
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CPT: 82160
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Special Instructions

Note: This test is not the same as Androstenedione. (See tests 004705 and 500152.)

Expected Turnaround Time

8 - 12 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Specimen Requirements

Specimen

Serum (preferred) or EDTA plasma, frozen

Volume

1 mL

Minimum Volume

0.4 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube (Do not use gel-barrier tube.) or lavender-top (EDTA) tube

Collection

Centrifuge and separate serum or plasma immediately. Freeze. Send serum or plasma in a plastic transport tube

Storage Instructions

Freeze

Stability Requirements

Temperature

Period

Room temperature

9 hours

Refrigerated

7 days

Frozen

7 days

Freeze/thaw cycles

Stable x6

Causes for Rejection

Sample received thawed; gross hemolysis

Test Details

Use

Androsterone is a major metabolite of testosterone and androstenedione along with the enantiomer etiocholanolone. Androsterone is also part of the "backdoor pathway" from allopregnanolone to dihydrotestosterone, which has importance in certain disease states. Androsterone is one of a few steroids with neutral activity that interact with γ-aminobutyric acid (GABA) receptors.

Limitations

Results of this test are for investigational purposes only. The performance characteristics of this assay have been determined by LabCorp. The result should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

Methodology

High-pressure liquid chromatography (HPLC)/tandem mass spectrometry (MS-MS)

References

Kaminski RM, Marini H, Kim WJ, Rogawski MA. Anticonvulsant activity of androsterone and etiocholanolone. Epilepsia. 2005 Jun; 46(6):819-827. 15946323

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
504005 Androsterone, Serum, LCMS 1856-4 504006 Androsterone, Serum, LCMS ng/dL 1856-4

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