Test Details
Methodology
See individual tests.
Result Turnaround Time
7 - 15 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Test Includes
α2-Antiplasmin assay; euglobulin lysis time; factor VIII activity; factor VIII chromogenic; factor IX activity; factor XI activity; factor XIII activity; fibrinogen activity; PAI-1 activity with reflex to PAI-1 antigen and tissue plasminogen activator (tPA); von Willebrand factor activity; von Willebrand factor antigen
Use
To assist in the determination of a cause of bleeding in a patient with normal aPTT and PT.
Limitations
This procedure may be considered by Medicare and other carriers as investigational and, therefore, may not be payable as a covered benefit for patients.
Specimen Requirements
Specimen
Plasma, frozen
Volume
7 mL platelet-poor frozen citrated plasma divided into seven tubes
Container
Blue-top (sodium citrate) tube
Collection Instructions
Plasma must be separated from cells within 45 minutes of venipuncture and plasma centrifuged a second time before being placed in plastic transport tubes. Freeze within two hours and keep frozen until testing is performed.
Storage Instructions
Freeze.
Causes for Rejection
Noncitrated plasma; gross hemolysis; fibrin clot in plasma
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 503541 | Bleeding Diathesis | 500666 | Factor VIII Activity | % | 3209-4 | |
| 503541 | Bleeding Diathesis | 500193 | FVIII Chromogenic | % | 49865-9 | |
| 503541 | Bleeding Diathesis | 500672 | Factor IX Activity | % | 3187-2 | |
| 503541 | Bleeding Diathesis | 500674 | Factor XI Activity | % | 3226-8 | |
| 503541 | Bleeding Diathesis | 500186 | Factor XIII Activity** | % | 27815-0 | |
| 503541 | Bleeding Diathesis | 500701 | Fibrinogen Activity | mg/dL | 3255-7 | |
| 503541 | Bleeding Diathesis | 500669 | von Willebrand Factor Activity | % | 6014-5 | |
| 503541 | Bleeding Diathesis | 500668 | von Willebrand Factor Antigen | % | 27816-8 | |
| 503541 | Bleeding Diathesis | 501175 | Alpha-2 Antiplasmin Assay | % | 27810-1 | |
| 503541 | Bleeding Diathesis | 500616 | PAI-1 Activity | IU/mL | 5975-8 | |
| 503541 | Bleeding Diathesis | 503479 | Euglobulin Lysis Time | 40454-1 | ||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 500666 | |||||
| Result Code Name | Factor VIII Activity | |||||
| UofM | % | |||||
| Result LOINC | 3209-4 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 500193 | |||||
| Result Code Name | FVIII Chromogenic | |||||
| UofM | % | |||||
| Result LOINC | 49865-9 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 500672 | |||||
| Result Code Name | Factor IX Activity | |||||
| UofM | % | |||||
| Result LOINC | 3187-2 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 500674 | |||||
| Result Code Name | Factor XI Activity | |||||
| UofM | % | |||||
| Result LOINC | 3226-8 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 500186 | |||||
| Result Code Name | Factor XIII Activity** | |||||
| UofM | % | |||||
| Result LOINC | 27815-0 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 500701 | |||||
| Result Code Name | Fibrinogen Activity | |||||
| UofM | mg/dL | |||||
| Result LOINC | 3255-7 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 500669 | |||||
| Result Code Name | von Willebrand Factor Activity | |||||
| UofM | % | |||||
| Result LOINC | 6014-5 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 500668 | |||||
| Result Code Name | von Willebrand Factor Antigen | |||||
| UofM | % | |||||
| Result LOINC | 27816-8 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 501175 | |||||
| Result Code Name | Alpha-2 Antiplasmin Assay | |||||
| UofM | % | |||||
| Result LOINC | 27810-1 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 500616 | |||||
| Result Code Name | PAI-1 Activity | |||||
| UofM | IU/mL | |||||
| Result LOINC | 5975-8 | |||||
| Order Code | 503541 | |||||
| Order Code Name | Bleeding Diathesis | |||||
| Order Loinc | ||||||
| Result Code | 503479 | |||||
| Result Code Name | Euglobulin Lysis Time | |||||
| UofM | ||||||
| Result LOINC | 40454-1 |
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 503551 | PAI-1+TPA Ag | 500030 | TPA Antigen | ng/mL | 5971-7 |
| Reflex 1 | ||||||
| Order Code | 503551 | |||||
| Order Name | PAI-1+TPA Ag | |||||
| Result Code | 500030 | |||||
| Result Name | TPA Antigen | |||||
| UofM | ng/mL | |||||
| Result LOINC | 5971-7 | |||||
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
|---|---|---|---|---|---|---|
| Reflex 1 | 503551 | PAI-1+TPA Ag | 500059 | PAI-1 Antigen | ng/mL | 22758-7 |
| Reflex 1 | ||||||
| Order Code | 503551 | |||||
| Order Name | PAI-1+TPA Ag | |||||
| Result Code | 500059 | |||||
| Result Name | PAI-1 Antigen | |||||
| UofM | ng/mL | |||||
| Result LOINC | 22758-7 | |||||